Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Recent Progresses of Understanding the Viscosity of Concentrated Protein Solutions

Published

Author(s)

Zhenhuan NMN Zhang, Yun Liu

Abstract

Viscosity control for concentrated protein solutions is very important for the manufacturability and and drug delivery routes of many protein therapeutics of the pharmaceutical industry. Even though there are successful applications of colloidal theories to calculate or predict the viscosity of globular proteins with electrostatic repulsions, understanding concentrated protein solutions remains an open challenge for colloidal science. This is especially true when proteins have complicated interaction potentials and non-spherical shapes, such as monoclonal antibody proteins. This paper provides a brief review of the recent experimental and theoretical progresses in understanding the viscosity of concentrated protein solutions with a focus on the experimental results.
Citation
Current Opinion in Chemical Engineering
Volume
16

Keywords

Protein-Protein interactions, structure-viscosity relationship, rheology, monoclonal antibodies

Citation

, Z. and Liu, Y. (2017), Recent Progresses of Understanding the Viscosity of Concentrated Protein Solutions, Current Opinion in Chemical Engineering, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=922423 (Accessed June 18, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created May 1, 2017, Updated October 30, 2017