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Displaying 51 - 75 of 164

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis

September 21, 2012
Author(s)
Shiv Kumar, Tao Chuanjuan, Chien Minchen, Hellner Brittney, Joseph W. Robertson, Arvind Balijepalli, Li Zengmin, James J. Russo, Joseph E. Reiner, John J. Kasianowicz, Jingyue Ju
There is a significant need to accurately sequence single DNA and RNA molecules for personalized medicine. We describe a novel nanopore-based sequencing by synthesis (SBS) strategy that will accurately differentiate at single molecule level four different

SEM Induced Shrinking of Solid State Nanopores for Single Molecule Detection

September 22, 2011
Author(s)
Anmiv Prahbu, Kevin J. Freedman, Joseph W. Robertson, Zhorro Nikolov, John J. Kasianowicz, MinJun Kim
We have investigated the shrinkage of solid state nanopores by a scanning electron microscope and find the process to be reproducible and dependant beam parameters such as the accelerating voltage and electron flux. The shrinking phenomenon does not

Theory for Polymer Analysis Using Nanopore-based Single-molecule Mass Spectrometry

June 1, 2010
Author(s)
Joseph E. Reiner, John J. Kasianowicz, Brian J. Nablo, Joseph W. Robertson
Nanometer-scale pores have demonstrated potential as a tool for the electrical detection and characterization of molecules. To provide a physical basis for nanopore-based analytical metrology, we show that a simple model quantitatively describes how one

Probing Single Nanometer-Scale Pores with Polymeric Molecular Rulers

April 2, 2010
Author(s)
Sarah E. Henrickson, Edmund A. DiMarzio, Qian Wang, Vincent M. Stanford, John J. Kasianowicz
It has been shown that individual molecules of single stranded DNA can be driven electrophoretically through a single Staphylococcus aureus ?-hemolysin ion channel. Polynucleotides thread through the channel as extended chains and the polymer-induced ionic
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