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Displaying 76 - 100 of 2015

Overcoming Technological Barriers in Microfluidics: Leakage Testing

September 1, 2022
Author(s)
Vania Silverio, Suvajyoti Guha, Armelle Keiser, Rucha Natu, Darwin Reyes-Hernandez, Henne van Heeren, Nicolas Verplanck, Luke Herbertson
The miniaturization of laboratory procedures for Lab-on-Chip (LoC) devices and translation to various platforms such as single cell analysis or Organ-on-Chip (OoC) systems are revolutionizing the life sciences and biomedical fields. As a result

Levels and profiles of perfluorinated alkyl acids in liver tissues of birds with different habitat types and trophic levels from an urbanized coastal region of South Korea

August 1, 2022
Author(s)
Sang Hee Hong, Jessica L. Reiner, Mi Jang, Stacy Schuur, Gi Myung Han, John Kucklick, Won Joon Shim
Contamination status and characteristics of perfluorinated alkyl acids (PFAAs) including perfluorinated carboxylic acids (PFCAs) and perfluorinated sulfonic acids (PFSAs) was examined using liver tissue of birds - blacktailed gulls (Larus crassirostris)

Enhancing untargeted metabolomics using metadata-based source annotation

July 7, 2022
Author(s)
Scott Jackson, Paulina Piotrowski, Nancy Lin, Sandra M. Da Silva, Katrice Lippa, Christina Jones, Stephanie Servetas, Julia Gauglitz, Kiana West, Wout Bittremieux, Candace Williams, Kelly Weldon, Morgan Panitchpakdi, Francesca Ottavio, Christine Aceves, Elizabeth Brown, Nicole Sikora, Alan Jarmusch, Cameron Martino, Pieter Dorrestein, Rob Knight, Rachel Dutton, Austin Swafford, Monica Guma, Norberto Peporine Lopes, Brigid Boland, Michelli Oliveira, Mark Manary, Maria Gloria Dominguez-Bello, Kenneth Wright, Julia Beauchamp-Walters, Kyung Rhee, Jae Kim, Megan Doty, Robert Terkeltaub, David Gonzalez, Curt Wittenberg, Tatyana Kalashnikova, Parambir Dulai, Douglas Galasko, Rima Kaddurah Daouk, Robert Mills, Paulo Louzada-Junior, Rene Donizeti Ribeiro Oliveira, Thaigo Mattar Cunha, Flavio Protaso Veras, Rodrigo Moreira Silva, Juliano Geraldo Amaral, Lucas Maciel Mauriz Marques, Barry Bradford, Lourdes Herrera, Gail Ackermann, Dana Withrow, Daniela Vargas Robles, Kate Sprecher, Clarisse Marotz, Mingxun Wang, Emmanuel Elijah, Dominic Nguyen, Qiyun Zhu, Daniel McDonald, Edgar Diaz, Pedro Belda-Ferre, Katharina Spengler, Abigail Johnson, Gregory Humphrey, MacKenzie Bryant, Tara Schwartz, Lindsay Goldasich, Fernando Vargas, Roxana Coras, Justin Schaffer, Erfan Sayyari, Kathleen Dorrestein, Michael Meehan, Anupriya Tripathi
Human untargeted metabolomics studies annotate only 10% of molecular features. We introduce reference-data-driven analysis to match metabolomics tandem mass spectrometry (MS/MS) data against metadata-annotated source data as a pseudo-MS/MS reference

Errors-in-variables calibration with dark uncertainty

June 16, 2022
Author(s)
Christina Cecelski, Blaza Toman, Fong-Ha Liu, Juris Meija, Antonio Possolo
A model for errors-in-variables regression is described that can be used to overcome the challenge posed by mutually inconsistent calibration data. The model and its implementation are illustrated in applications to the measurement of the amount fraction

Spectrophotometric Measurement of Carbonate Ion in Seawater over a Decade: Dealing with Inconsistencies

June 7, 2022
Author(s)
Elisa Guallart, Noelia Fajar, Maribel Garcia-Ibanez, Monica Castano-Carrera, Rocio Santiago-Domenech, Abed El Rahman Hassoun, Fiz Perez, Regina Easley, Marta Alvarez
The spectrophotometric methodology for carbonate ion determination in seawater was first published in 2008 and has been continuously evolving in terms of reagents and formulation. Although the method proves to be fast, relatively simple and affordable

Protocols for leakage testing

June 1, 2022
Author(s)
Henne van Heeren, Matthew Davies, Armelle Keiser, Rudy Lagrauw, Darwin Reyes-Hernandez, Vania Silverio, Nicolas Verplanck
This document is written to serve as a guideline for the testing of microfluidic devices, which are devices designed to manipulate fluids that are confined in a small volume. For instance, a channel with at least one dimension smaller than 1 mm is a

Communicating Confidence of Per- and Polyfluoroalkyl Substance (PFAS) Identification via High Resolution Mass Spectrometry

May 26, 2022
Author(s)
Joseph Charbonnet, Carrie McDonough, Feng Xiao, Trever Schwichtenberg, Dunping Cao, Sarit Kaserzon, Kevin Thomas, Pradeep Dewapriya, Benjamin Place, Emma Schymanski, Jennifer Field, Damian Helbling, Christopher Higgins
Per- and polyfluoroalkyl substances (PFASs) are important environmental contaminants, yet relatively few analytical reference standards exist for this class. Nontarget analyses performed by means of high-resolution mass spectrometry (HRMS) are increasingly

Interlaboratory Studies using the NISTmAb to Advance Biopharmaceutical Structural Analytics

May 5, 2022
Author(s)
Katharina Yandrofski, Trina Mouchahoir, M. Lorna De Leoz, David L. Duewer, Jeffrey W. Hudgens, Kyle Anderson, Luke Arbogast, Frank Delaglio, Robert Brinson, John Marino, Karen W. Phinney, Michael J. Tarlov, John E. Schiel
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material properties must be characterized and well controlled to assure that clinically relevant features and

Assessing Arsenic Species in Foods Using Regularized Linear Regression of the Arsenic K-edge X-ray Absorption Near Edge Structure

April 19, 2022
Author(s)
Evan Jahrman, Lee L. Yu, William P. Krekelberg, David Sheen, Thomas C. Allison, John L. Molloy
The toxicity and bioavailability of arsenic is heavily dependent on its speciation. Therefore, robust and accurate methods are needed to determine arsenic speciation profiles for materials related to public health initiatives, such as food safety. Here, X

Reference Materials for MS-based Untargeted Metabolomics and Lipidomics: A Review by the Metabolomics Quality Assurance and Quality Control Consortium (mQACC)

April 9, 2022
Author(s)
Katrice Lippa, William Davis, Christina Jones, Tracey Schock, Juan Aristizabal-Henao, Richard Beger, John Bowden, Corey Broeckling, Chris Beecher, Warwick Dunn, Roberto Flores, Goncalo Gouveia, Thomas Hartung, Matthew Lewis, Ioanna Ntai, Andrew Percy, Dan Raftery, Jinchun Sun, Georgios Theodoridis, Fariba Tayyari, Federico Torta, Candice Ulmer, Baljit Ubhi
Introduction The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control

Size-Exclusion Chromatography: A twenty-first Century Perspective

April 4, 2022
Author(s)
Andre Striegel
Now in its sixth decade, size-exclusion chromatography (SEC) remains the premier method by which to determine the molar mass averages and distributions of natural and synthetic macromolecules. Aided by its coupling to a variety and multiplicity of

Coherent anti-Stokes Raman scattering (CARS) microscopy for polymers

April 1, 2022
Author(s)
Shuyu Xu, Charles Camp, Young Jong Lee
Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free chemical imaging modality capable of interrogating local molecular composition, concentration, and even orientation. In comparison to traditional Raman spectroscopy/imaging, CARS
Displaying 76 - 100 of 2015