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Search Publications

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Displaying 926 - 950 of 2355

Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody

March 11, 2015
Author(s)
John E. Schiel, Cyrus D. Agarabi, Scott C. Lute, Brittany K. Chavez, Michael T. Boyne, Kurt A. Brorson, Mansoor A. Kahn, Erik K. Read
Consistent high quality antibody yield is a key goal for cell culture bioprocessing. This endpoint is typically achieved in commercial settings through product and process engineering of bioreactor parameters during development. When the process is complex

Quantification of Cells with Specific Phenotypes I: Determination of CD4+ Cell Count per mL in Reconstituted Lyophilized Human PBMC Pre-labelled with Anti-CD4 FITC Antibody

March 10, 2015
Author(s)
Richard Stebbings, Lili Wang, Janet Sutherland, Martin Kammel, Adolfas Gaigalas, M. John, B. Roemer, M. Kuhne, R. J. Schneider, M. Braun, N. Leclere, D. Dikshit, Fatima Abbasi, Gerald Marti, P. Porcedda, M. Sassi, L. Revel, S. K. Kim, D. Marshall, L. Whitby, Jing Wang, V. Ost, M. Vonski, Joerg Neukammer
A surface-labelled lyophilised lymphocyte (sLL) preparation has been developed using human peripheral blood mononuclear cells (PBMC) pre-labelled with a fluorescein isothiocyanate (FITC) conjugated anti-CD4 monoclonal antibody. The sLL preparation is

Proceedings of SPIE

March 4, 2015
Author(s)
Maritoni A. Litorja, Aaron A. Urbas, Yuqin Zong
The fluorescent light detected by a clinical imager is assumed to be proportional to the amount of fluorescent substance present in the sample. Unfortunately, there are many factors that can add or subtract to the light signal directly attributable to the

An analytical framework for optimizing variant discovery from personal genomes

February 25, 2015
Author(s)
Justin M. Zook, Gareth Highnam, Jason Wang, Dean Kusler, Vinaya Vijayan, Nir Leibovich, David Mittelman
The standardization and performance testing of analysis tools is a prerequisite to widespread adoption of high-throughput sequencing, particularly in the clinic. However, performance testing is currently complicated by the paucity of standards and

Application of NMR-based Metabolomics for Environmental Assessment in the Great Lakes using Zebra Mussel (Dreissena polymorpha) polymorpha)

February 21, 2015
Author(s)
Miki Watanabe, Katherine Meyer, Tyler Jackson, Tracey Johnston, Ed Johnson, Dan Bearden
Zebra mussel, Dreissena polymorpha, in the Great Lakes is being monitored as a bio-indicator organism for environmental health effects by the National Oceanic and Atmospheric Administration's Mussel Watch program. In order to monitor the environmental

Evaluation of Low-Contrast Detectability of Iterative Reconstruction across Multiple Institutions, CT Scanner Manufacturers, and Radiation Exposure Levels

February 19, 2015
Author(s)
Adele P. Peskin, Ganesh Saiprasad, James J. Filliben, Alden A. Dima
Purpose: To evaluate the impact of Iterative Reconstruction (IR) compared with Filtered Back Projection (FBP) using low-contrast objects in phantom images across vendors and exposure levels. Materials and Methods: Randomized repeat scans of the Gammex 464

Scaling of Testing Speed for Different Source-to-Detector Distances

February 13, 2015
Author(s)
Bruce R. Norman, Anne L. Sallaska, Leticia Pibida
Several American National Standard Institute/Institute of Electrical and Electronics Engineers (ANSI/IEEE) and International Electrotechnical Commission (IEC) standards were developed for radiation detection systems used for homeland security applications

Rapid DNA melting analyses using a microfabricated electrochemical platform

January 1, 2015
Author(s)
Zuliang Shen, Stephen Semancik, Herman O. Sintim
A new microscale platform is reported which is based on microfabrication methods that integrate thermal control and multi-electrode components to enable rapid temperature-dependent electrochemical measurements on small volume fluid samples. We demonstrate

Optical Properties of CdSe/ZnS Nanocrystals

December 31, 2014
Author(s)
Paul C. DeRose, Yu-Zhong Zhang, Adolfas Gaigalas
Measurements are presented of the absorbance, fluorescence emission, fluorescence quantum yield, and fluorescence lifetime of CdSe/ZnS nanocrystals, also known as quantum dots (QDs). The study included three groups of nanocrystals whose surfaces were
Displaying 926 - 950 of 2355
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