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Displaying 76 - 100 of 533

Curated variation benchmarks for challenging medically relevant autosomal genes

February 7, 2022
Author(s)
Justin Wagner, Nathanael David Olson, Lindsay Harris, Jennifer McDaniel, Fritz Sedlazeck, Chen-Shan Chin, Justin Zook
The repetitive nature and complexity of some medically relevant genes poses a challenge for their accurate analysis in a clinical setting. The Genome in a Bottle Consortium has provided variant benchmark sets, but these exclude nearly 400 medically

New reference materials for trace-levels of actinide elements in plutonium

January 27, 2022
Author(s)
Richard Essex, Lav Tandon, Amy Gaffney, Cole Hexel, Debbie Bostick, Lisa Colletti, Diana Decker, Casey Finstad, Joseph Giaquinito, Elmer Lujan, John Partridge, Benjamin Roach, John Rolinson, Kyle Samperton, Alice Slemmons, Khalil Spencer, Floyd Stanley, Lisa Townsend, Kerri Treinen, Ross Williams, Christopher Worley
Two plutonium oxides were prepared as unique reference materials for actinides occurring as trace constituents in Pu. Each reference material unit is approximately 200 mg of PuO2 in a quartz glass vial. Characterized attributes of the oxides included mass

Certification of Standard Reference Material(R) 2386 Avocado Powder

October 20, 2021
Author(s)
Melissa M. Phillips, Laura J. Wood, George Caceres, Grace Hahm, Karen E. Murphy, Rick L. Paul, Benjamin Place, James H. Yen
The National Institute of Standards and Technology (NIST) recently released SRM 2386 Avocado Powder which has value assignment for over 70 analytes. This material has certified values assigned for 22 analytes and non-certified values assigned for 53

Improving end-user trust in the quality of commercial probiotic products

September 24, 2021
Author(s)
Scott Jackson, Jean Schoeni, Buffy Stahl
In a rapidly growing global probiotic market, end-users have difficulty distinguishing between high quality and poor quality products. This threatens consumer and healthcare provider trust in probiotic products. To address this problem, we recommend that

Health Assessment Measurements Quality Assurance Program: Exercise 6 Final Report

September 20, 2021
Author(s)
Chuck Barber, Carolyn Burdette, Hugh Hayes, Monique Johnson, Shaun Kotoski, Jacolin Murray, Melissa M. Phillips, Kate Rimmer, Laura J. Wood, Andrea Yarberry
The Health Assessment Measurements Quality Assurance Program (HAMQAP) was launched in collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) in 2017. HAMQAP was established to enable laboratories to improve the

Assessing the Microscale Heterogeneity in Candidate Standard Reference Material 4600: Surrogate Post-detonation Urban Debris

August 18, 2021
Author(s)
Jacqueline L. Mann, John L. Molloy, Mark Tyra, Kevin Pfeuffer, Barbara Fallon, JoAnn Buscaglia
Nondestructive microbeam X-ray fluorescence (µXRF) spectrometry has been used to investigate the elemental microheterogeneity in a candidate nuclear forensics reference material (RM), NIST SRM 4600: Surrogate Post-detonation Urban Debris. Using a principal

Challenges of Accuracy in Germline Clinical Sequencing Data

July 20, 2021
Author(s)
Justin Zook, Ryan Poplin, Mark DePristo
Physicians are increasingly using clinical sequencing tests to establish diagnoses of patients who might have genetic disorders, which means that accuracy of sequencing and interpretation are important elements in ensuring the benefits of genetic testing

Reference standards for accurate validation and optimization of assays that determine integrated Lentiviral vector copy number in transduced cells

July 11, 2021
Author(s)
Barbara S. Paugh, Lajos Baranyi, Andre Roy, Hua-Jun He, Lindsay Harris, Kenneth Cole, Caroline Raimund, Patricia S. Langan, Moria Artlip, Srikanta Jana, Rimas J. Orentas, Sheng Lin-Gibson, Winfried Krueger, Boro Dropuli?
Lentiviral vectors (LV) have emerged as a robust technology for therapeutic gene delivery into human cells as advanced medicinal products. As these products are increasingly commercialized, there are concomitant demands for their characterization to ensure

Reference Materials for Phase Equilibrium Studies. 1. Liquid-Liquid Equilibria (IUPAC Technical Report)

July 8, 2021
Author(s)
Ala Bazyleva, William E. Acree, Jr., Robert D. Chirico, Vladimir Diky, Glenn T. Hefter, Johan Jacquemin, Joe W. Magee, John P. O'Connell, James D. Olson, Ilya Polishuk, Kurt Schmidt, John M. Shaw, J. P. M. Trusler, Ronald D. Weir
This article is the first of three projected IUPAC Technical Reports resulting from IUPAC Project 2011-037-2-100 (Reference Materials for Phase Equilibrium Studies). The goal of that project was to select reference systems with critically evaluated

Assessment of Serum Total 25 Hydroxyvitamin D Assay Commutability of Standard Reference Materials and College of American Pathologists Accuracy Based Vitamin D (ABVD) Scheme and Vitamin D External Quality Assessment Scheme (DEQAS) Materials: Vitamin D Sta

July 1, 2021
Author(s)
Johanna Camara, Stephen A. Wise, Andrew Hoofnagle, Emma L. Williams, Graham D. Carter, Julia C. Jones, Carolyn Burdette, Grace Hahm, Federica Nalin, Adam J. Kuszak, Joyce M. Merkel, Ramon Durazo-Arvizu, Pierre Lukas, E. Cavalier, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Fiona Ivison, Ralf Fischer, Jody M. van den Ouweland, Chung S. Ho, Emmett W. Law, Jean-Nicolas Simard, Renaud Gonthier, Brett Holmquist, Marcelo C. Batista, Heather Pham, Alex Bennett, Sarah Meadows, Lorna Cox, Eugene Jansen, Dilshad A. Khan, Kimberly Robyak, Michael H. Creer, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Jinyun Yuan, Robert Fitzgerald, Sohail Mushtaq, Michael W. Clarke, Norma Breen, Christine Simpson, Christopher T. Sempos
An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality assessment (PT/EQA) samples for determination of serum

Polarization Effects of X-ray Monochromators Modeled Using Dynamical Scattering Theory

July 1, 2021
Author(s)
Marcus Mendenhall, David R. Black, Donald Windover, James Cline
The difference in the diffracted intensity of the sigma-and pi-polarized components of an X-ray beam in powder diffraction has generally been treated according to equations based on dipole scattering, also known as kinematic X-ray scattering. Although this

Dynamic light scattering distributions by any means

May 21, 2021
Author(s)
Natalia Farkas, John A. Kramar
Dynamic light scattering (DLS) is an essential technique for nanoparticle size analysis and has been employed extensively for decades, but despite its long history and popularity, the choice of weighting and mean of the size distribution often appears to

A Highly-enriched 244Pu Reference Material for Nuclear Safeguards and Nuclear Forensic Measurements

January 26, 2021
Author(s)
Richard Essex, Ross W. Williams, Kerri C. Treinen, Amelie Hubert, Marc A. Humphrey, Jeremy D. Inglis, William S. Kinman, Joel Maassen, Maxim V. Penkin, Robert E. Steiner
A highly-enriched 244Pu isotope dilution reference material has been prepared and characterized for metrologically traceable measurements of very small quantities of plutonium. The amount of plutonium in samples associated with nuclear safeguards and

A new highly enriched 233U reference material for improved simultaneous determination of uranium amount and isotope amount ratios in trace level samples

January 26, 2021
Author(s)
Richard Essex, Ross W. Williams, Kayron T. Rogers, Cole R. Hexel, Tashi Parsons-Davis, Kerri C. Treinen
A highly-enriched 233U reference material (>0.99987 n(233U)/n(U)) has been prepared and characterized for use as an isotope dilution mass spectrometry spike. An ion exchange separation was performed on 1 gram of high purity 233U to further reduce trace
Displaying 76 - 100 of 533
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