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Search Publications

NIST Authors in Bold

Displaying 9826 - 9850 of 13225

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

January 1, 2019
Author(s)
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony J. Kearsley, Yves Aubin, Gregory Pierens, Xinying Jia, David Keizer, Jonas Stahle, Goran Widmalm, Chad Lawrence, Patrick Reardon, John Cort, Koichi Kato, Stuart Parnham, Andreas Blomgren, Torgny Rundlof, Kang Chen, David Keire, Thea Suter-Stahel, Gerhard Wider, Donna Baldisseri, Julie Wu, Mats Wikstrom, Medhi Mobli
… Of the top ten drugs on the global market in 2016, seven of them are biologics with a combined market … many of them monoclonal antibodies (mAbs), are in some stage of clinical development. With increasing … for establishing consistency in biopharmaceutical manufacturing, detecting process-related product variations …

Investigation of a Simulated Chinese Jade Dagger by Neutron Radiography and Prompt Gamma Activation Analysis

August 15, 2018
Author(s)
Richard Livingston, Ariel O'Connor, Jacob LaManna, Heather H. Chen-Mayer, Danyal J. Turkoglu
… In ancient China during the Shang dynasty, ca. 1600-1046 BCE, … of a nephrite jade [Ca2(Mg, Fe)5Si8O22(OH)2] blade mounted in a bronze haft. Several of these daggers are held by the … jade tang hidden within the bronze haft and uncover early manufacturing techniques. As a preliminary test of …

Spectral tuning of localized surface phonon-polariton modes in selective area epitaxy GaN nanowire arrays

May 1, 2018
Author(s)
Bryan T. Spann, J. Ryan Nolen, Matthew D. Brubaker, Thomas G. Folland, Chase T. Ellis, Joseph G. Tischler, Todd E. Harvey, Joshua D. Caldwell, Kristine A. Bertness
… Here, we explore aspects of Raman active of SPhP modes in GaN nanowire arrays grown by selectively area molecular beam epitaxy. As demonstrated in Figure 1A, we observe strong Raman peaks (labeled P1 and … red-shifted from the LO phonon. These modes do not occur in bulk GaN and occur around 700 cm-1 (~ 14.3 µm), offering a …

Instrumented impact testing of miniaturized Charpy specimens of AM Ti-6Al-4V

April 11, 2018
Author(s)
Enrico Lucon, Nikolas W. Hrabe
… and lateral expansion were obtained by performing tests in the temperature range between -196 °C and 700 °C. Testing … When testing above room temperature, specimens were heated in a small furnace and their temperature was monitored by … and that the material is more resistant to cracks growing in the plane perpendicular to the build direction than in the …

Estimating Error Rates for Firearm Evidence Identifications in Forensic Science

March 1, 2018
Author(s)
Jun-Feng Song, Theodore V. Vorburger, Wei Chu, James H. Yen, Johannes A. Soons, D Ott, Nien F. Zhang
… firearm evidence identification is a fundamental challenge in forensic science. This paper describes the recently … a statistical foundation for estimating error rates in firearm evidence identifications, thus emulating methods … Estimating Error Rates for Firearm Evidence Identifications in Forensic Science …

Differential degradation patterns of photovoltaic backsheets at the array level

February 4, 2018
Author(s)
Andrew W. Fairbrother, Matthew Boyd, Yadong Lyu, Julien Avenet, Peter Illich, Michael Kempe, Brian P. Dougherty, Laura Bruckman, Xiaohong Gu
… failure of a module, and as such is an important factor in system reliability and longevity. Some module … begun utilizing non-fluoropolymer-based backsheets in a bid to reduce overall cost, however, these materials … backsheets, and understanding their in-field behavior is critical for further development of such …

Tolerances and Uncertainty in Robotic Systems

November 8, 2017
Author(s)
Frederick M. Proctor, John L. Michaloski, Marek Franaszek
… and occupies personnel, limiting their effectiveness in these environments. Off-line programming solves these … engineering and application development, but results in systems that can operate in a wider range of requirements … Automating this optimization is a goal of smart manufacturing. With its trend of increasing connectivity …

Optimizing image-based patterned defect inspection through FDTD simulations at multiple ultraviolet wavelengths

June 25, 2017
Author(s)
Bryan Barnes, Hui Zhou, Mark-Alexander Henn, Martin Sohn, Richard M. Silver
… The sizes of non-negligible defects in the patterning of a semiconductor device continue to … of the device and must be adequately controlled during manufacturing, and new solutions are required to improve … from a deep-ultraviolet wavelength to wavelengths in the vacuum ultraviolet and the extreme ultraviolet. In …

Resonant Acoustic Frequency Shifts Associated with Cracks in Multilayer Ceramic Capacitors

June 6, 2017
Author(s)
Ward L. Johnson, Jaemi Herzberger, Sudook A. Kim, Kirsten L. Peterson, Paul R. Heyliger, Grady S. White
… Resonant ultrasound spectroscopy (RUS) was used in this study to measure shifts in resonant frequency that arise from the presence of cracks in barium-titanate-based multi-layer ceramic capacitors … Resonant Acoustic Frequency Shifts Associated with Cracks in Multilayer Ceramic Capacitors …

High Strain Rate Mechanical Characterization of Carbon Fiber Reinforced Polymer Composites using Digital Image Correlations

March 28, 2017
Author(s)
Louise A. Ahure Powell, William E. Luecke, Matthias J. Merzkirch, Timothy J. Foecke, Katherine Avery
… polymer (CFRP) composites to structural components in lightweight automotive structures necessitates an … of safety compared to conventional metallic structures. In order to develop, integrate and implement predictive … performance requirements to enable optimal design and manufacturing vehicle systems for this study, the dynamic …

Process Optimization for Lattice-Selective Wet Etching of Crystalline Silicon Structures

March 9, 2016
Author(s)
Ronald G. Dixson, William F. Guthrie, Richard A. Allen, Ndubuisi G. Orji, Michael W. Cresswell, Christine E. Murabito
… Lattice-selective etching of silicon is used in a number of applications, but it is particularly valuable in those for which the lattice-defined sidewall angle can be … reference tools for linewidth metrology in semiconductor manufacturing. Accurate linewidth metrology using CD-AFM, …

Measuring laser power as a force: A new paradigm to accurately monitor optical power during laser-based machining operations

February 14, 2016
Author(s)
Paul A. Williams, Brian J. Simonds, Jeffrey W. Sowards, Joshua A. Hadler
… In laser manufacturing operations, accurate measurement of laser power … thermal power meters must absorb all the laser power in order to measure it. This forces power meters to be large, … these limitations, we have developed a different paradigm in laser power measurement where the power is not measured …

Design of a breast phantom for quantitative MRI

January 1, 2016
Author(s)
Kathryn E. Keenan, Sheye O. Aliu, Lisa J. Wilmes, David C. Newitt, Ella F. Jones, Wen Li, Michael A. Boss, Nola M. Hylton
… This phantom enables T 1 and ADC measurements, fits in a variety of clinical breast coils, and can serve as a …

Structure-property relationships in bimodal polyethylene from indentation measurements

June 8, 2015
Author(s)
Aaron Forster, Wei-Lun Ho, Kar T. Tan, Donald Hunston
… properties under a multi- axial stress state. In this work, instrumented indentation is used to develop … Five different polyethylene resins used for pipe manufacturing are investigated. The impact of thermal … Structure-property relationships in bimodal polyethylene from indentation measurements …

"Weighing" a Gas With Microwave and Acoustic Resonances

March 24, 2015
Author(s)
Keith A. Gillis, James B. Mehl, James W. Schmidt, Michael R. Moldover
… With calibrations of large flow meters in mind, we established the feasibility of determining the … sound (and therefore the average temperature) of the gas in the tank, first-order perturbation theory predicts that f …

Nanomanufacturing Concerns about Measurements made in the SEM Part III: Vibration and Drift

December 1, 2014
Author(s)
Michael T. Postek, Andras Vladar, Petr Cizmar
… Many advanced manufacturing processes employ scanning electron microscopes … discussing various causes of measurement uncertainty in scanned particle beam instruments, and some of the … ease of operation has also fostered operator complacency. In addition, the user-friendliness has reduced the need for …

Flow Cytometer Performance Characterization, Standardization and Calibration against CD4 on T Lymphocytes Enables Quantification of Biomarker Expressions for Immunological Applications

August 7, 2014
Author(s)
Heba Degheidy, Steven R. Bauer, Gerald Marti, Lili Wang
… procedure for biomarker standardization and quantification in clinical laboratories. Measuring the expression levels of … diseases. One of the most significant challenges in flow cytometry is obtaining inter-laboratory and … be determined and transferred to selected cytometers. In this study, we optimized a procedure for instrument …

Incorporating Biometric Software Development Kits into the Development Process

August 1, 2014
Author(s)
Karen Marshall, Ross J. Micheals, Kevin C. Mangold, Kayee K. Hanaoka
… devices have emerged as pervasive and indispensable tools in facilitating security in many industries and governments worldwide�. The use of … themselves to the development process but instead result in adding complexity that impedes developer flexibility. The …

Uncertainty in Bogue-Calculated Phase Composition of Hydraulic Cements

July 1, 2014
Author(s)
Paul E. Stutzman
… The Bogue calculations of cement composition are used for manufacturing process control and cement classification. … variation due to the phase solid solution, resulting in deviation of their bulk chemistry form that is assumed in the calculations, and bulk oxide measurement …

Incorporating Biometric Software Development Kits into the Development Process

May 9, 2013
Author(s)
Karen Marshall, Ross J. Micheals, Kevin C. Mangold, Kayee K. Hanaoka
… devices have emerged as pervasive and indispensable tools in facilitating security in many industries and governments worldwide—the use of these … themselves to the development process but instead result in adding complexity that impedes developer flexibility. The …

Framework for the Evaluation of DNA Extract Suitability for Identification, Quantification and Sequencing of Unknown Microorganisms Microorganisms

December 3, 2012
Author(s)
Nathanael David Olson, Jayne D. Morrow
… organism is known, let alone when the organism is unknown. In this study, five different cells types (Gram positive (2), … of PCR inhibitors). DNA extracts varied significantly in terms of quantity by both cell type and extraction method, … than 90 percent of the extracted DNA was greater than 1 kb in size and therefore suitable for NGS and qPCR, and none of …

Collaborative Robotics: Measuring Blunt Force Impacts on Humans

October 12, 2012
Author(s)
Joseph A. Falco, Jeremy A. Marvel, Richard J. Norcross
… generation of industrial robots that are designed to work in collaborative environments in close proximity to humans. In parallel, an international standards effort is developing …
Displaying 9826 - 9850 of 13225
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