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Search Publications

NIST Authors in Bold

Displaying 1 - 25 of 654

Restricting a-Synuclein Transport into Mitochondria by Inhibition of a-Synuclein-VDAC Complexation as a Potential Therapeutic Target for Parkinson's Disease Treatment

October 1, 2022
Author(s)
Megha Rajendran, Maria Queralt-Martin, Philip A. Gurnev, William M. Rosencrans, Amandine Rovini, Daniel Jacobs, Kaitlin Abrantes, David Hoogerheide, Sergey M. Bezrukov, Tatiana Rostovtseva
Involvement of alpha-synuclein (αSyn) in Parkinson's disease (PD) is complicated and difficult to trace on cellular and molecular levels. Recently we established that αSyn can regulate mitochondrial function by voltage-activated complexation with the

Energy Broadening of Neutron Depth Profiles by Thin Polyamide Films

September 7, 2022
Author(s)
Jamie Weaver, Robert Gregory Downing, Anna Job, Kedar Manandhar, Ichiro Takeuchi
A protective covering is often required for neutron depth profiling (NDP) measurements of sensitive materials (e.g., Li-ion batteries). Addition of this layer can increase NDP profile energy broadening and depth assignment uncertainty. This study evaluates

Electrostatic Repulsion Slows Relaxations of Polyelectrolytes in Semidilute Solutions

July 19, 2022
Author(s)
Ali Slim, Winnie Shi, Farshad S. Samghabadi, Antonio Faraone, Amanda Marciel, Ryan Poling-Skutvik, Jacinta Conrad
We investigate the structure and dynamics of unentangled semidilute solutions of sodium polystyrene sulfonate (NaPSS) using small-angle neutron scattering (SANS) and neutron spin-echo (NSE) spectroscopy. The effects of electrostatic interactions and chain

Unraveling the Stable Cathode Electrolyte Interface in all Solid-State Thin-Film Battery Operating at 5 V

July 4, 2022
Author(s)
Ryosuke Shimizu, Diyi Cheng, Jamie Weaver, Minghao Zhang, Bingyu Lu, Thomas Wynn, Randall Burger, Min-cheol Kim, Guomin Zhu, Ying Shirley Meng
Spinel-type LiNi0.5Mn1.5O4 (LNMO) is one of the most promising 5 V-class cathode materials for Li-ion batteries that can achieve high energy density and low production costs. However, in liquid electrolyte cells, the high voltage causes continuous cell

Polyoxocationic Antimony Oxide Cluster with Acidic Protons

June 17, 2022
Author(s)
Yuki Watanabe, Kim Hyeon-Deuk, Takafumi Yamamoto, Masayoshi Yabuuchi, Olesia M. Karakulina, Yasuto Noda, Takuya Kurihara, I-Ya Chang, Masanobu Higashi, Osamu Tomita, Cedric Tassel, Daichi Kato, Jingxin Xia, Tatsuhiko Goto, Craig Brown, Yuto Shimoyama, Naoki Ogiwara, Joke Hadermann, Artem M. Abakumov, Sayaka Uchida, Ryu Abe, Hiroshi Kageyama
The success and continued expansion of research in polyoxometalates (POMs) owe largely to their structural richness and wide range of functions. However, while most POM clusters known to date are negatively charged, there is only a handful of cationic POMs

Structures and Dynamics of Anionic Lipoprotein Nanodiscs

April 21, 2022
Author(s)
D. Sweeney, Susan T. Krueger, Kakali Sen, John Hackett
Nanolipoprotein particles known as nanodiscs (NDs) have emerged as versatile and powerful tools for the stabilization of mem-brane proteins permitting a plethora of structural and biophysical studies. Part of their allure is their flexibility to

Q-Dependent Collective Relaxation Dynamics of Glass-Forming Liquid Ca 0.4 K 0.6 (NO 3 ) 1.4 Investigated by Wide-Angle Neutron Spin-Echo

April 19, 2022
Author(s)
Peng Luo, Yanqin Zhai, Peter Falus, Victoria Garcia Sakai, Monika Hartl, Maiko Kofu, Kenji Nakajima, Antonio Faraone, Y. Z
Employing high-intensity wide-angle neutron spin-echo spectroscopy, we measured the coherent intermediate scattering function of the prototypical ionic glass former Ca0.4K0.6(NO3)1.4 in the equilibrium and supercooled liquid state from 383 to 519 K

A Semi-Supervised Approach for Automatic Crystal Structure Classification

April 13, 2022
Author(s)
Satvik Lolla, Haotong Liang, Aaron Gilad Kusne, Ichiro Takeuchi, William D. Ratcliff
The structural solution problem can be a daunting and time consuming task. Especially in the presence of impurity phases, current methods such as indexing become more unstable. In this work, we apply the novel approach of semi-supervised learning towards

An Optical Investigation of the Heavy Fermion Normal State in Superconducting UTe 2

April 13, 2022
Author(s)
Sirak Mekonen, Chang-Jong Kang, Dipanjan Chaudhuri, David Barbalas, Sheng Ran, Gabriel Kotliar, Nicholas Butch, N. Armitage
The recently discovered superconductor, UTe2, has attracted immense scientific interest due to the experimental observations that suggest odd-parity superconductivity. It is believed that the material becomes a heavy-fermion metal at low temperatures

Transformation of Lipid Vesicles into Micelles by Adding Nonionic Surfactants: Elucidating the Structural Pathway and the Intermediate Structures

March 24, 2022
Author(s)
Igor K. Mkam Tsengam, Marzhana Omarova, Elizabeth Kelley, Alon V. McCormick, Geoffrey D. Bothun, Srinivasa R. Raghavan, Vijay T. John
The phospholipid lecithin (L) and the nonionic surfactant Tween 80 (T) are used together in various contexts, including in drug delivery and oil spill remediation. There is hence a need to elucidate the nanostructures in L/T mixtures, which is the focus of

Head on Comparison of Self- and Nano-Assemblies of Gamma Peptide Nucleic Acid Amphiphiles

February 9, 2022
Author(s)
Shipra Malik, Vikas Kumar, Chung-Hao Liu, Kuo-Chih Shih, Susan T. Krueger, Mu-Ping Neih, Raman Bahal
Peptide nucleic acids (PNAs) are nucleic acid analogs with superior hybridization properties and enzymatic stability than deoxyribonucleic acid (DNA). In addition to gene targeting applications, PNAs have garnered significant attention as bio-polymer due

Low-Background Neutron Reflectometry from Solid/Liquid Interfaces

February 1, 2022
Author(s)
David Hoogerheide, Joseph Dura, Brian B. Maranville, Charles Majkrzak
Liquid cells are an increasingly common sample environment for neutron reflectometry experiments and are critical for measuring the properties of materials at solid/liquid interfaces. Background scattering determines the maximum useful scattering vector

Dynamics of Molecular Associates in Methanol/Water Mixtures

January 26, 2022
Author(s)
Yanqin Zhai, Peng Luo, Jackson Waller, Jeffrey L. Self, Leland Harriger, Y. Z., Antonio Faraone
The dynamics of molecular associates in methanol/water mixtures was investigated using quasielastic neutron scattering. By measuring the signal from four methanol/water samples differing only by their isotopic composition, the relative motion of the water

Predicting the plateau modulus from molecular parameters of conjugated polymers

January 18, 2022
Author(s)
Abigail Fenton, Renxuan Xie, Melissa Aplan, Youngmin Lee, Michael Gill, Ryan Fair, Fabian Kempe, Michael Sommer, Chad R. Snyder, Enrique Gomez, Ralph Colby
The relationship between Kuhn length lk, Kuhn monomer volume v0, and plateau modulus GN0 , initially proposed by Graessley and Edwards for flexible polymers, and extended by Everaers, has a large gap in experimental data between the flexible and stiff

Considerations in applying neutron depth profiling to Li-ion battery research

December 14, 2021
Author(s)
Daniel Lyons, Jamie Weaver, Anne Co
Li distribution within micron-scale battery electrode materials is quantified with neutron depth profiling (NDP). This method allows determination of intra- and inter-electrode parameters such as lithiation efficiency, electrode morphology change and Li

The PROSPECT Experiment

December 14, 2021
Author(s)
Hans Pieter Mumm
The Precision Reactor Oscillation and Spectrum Experiment, PROSPECT, is designed to both perform a reactor-model independent search for eV-scale sterile neutrino oscillations at meter-long baselines and to make a precise measurement of the antineutrino

Solution Structures of Bacillus Anthracis Protective Antigen Proteins using Small Angle Neutron Scattering and Protective Antigen 63 Ion Channel Formation Kinetics

December 11, 2021
Author(s)
Ariel Michelman-Ribeiro, Kenneth A. Rubinson, Vitalii Silin, John J. Kasianowicz
We are studying the structures of bacterial toxins that form ion channels and catalyze macromolecule transport across membranes. For example, the crystal structure of the Staphylococcus aureus α-hemolysin (α-HL) channel in its functional state was

In-situ Monitoring of Protein Unfolding/Structural States under Cold High-Pressure Stress

November 26, 2021
Author(s)
Diana Gomes, Susana C. Marujo Teixeira, Juscelino Leao, Vladimir Razinkov, Wei Qi, Miguel Rodrigues, Christopher Roberts
Biopharmaceutical formulations may be compromised by freezing, which has been attributed to protein conformational changes at a low temperature, and adsorption to ice−liquid interfaces. However, direct measurements of unfolding/conformational changes in
Displaying 1 - 25 of 654