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Health

Human microbiome

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Displaying 1 - 11 of 11

A Sensitivity Analysis of Methodological Variables Associated with Microbiome Measurements

January 14, 2025
Author(s)
Samuel Forry, Stephanie Servetas, Jennifer Dootz, Monique Hunter, Jason Kralj, James Filliben, Scott Jackson
The particular experimental methods employed during metagenomic sequencing analyses of microbiome samples can significantly impact the resulting data but typically vary substantially between laboratories. In this study, a full factorial experimental design

Multi'omic Characterization of Human Whole Stool RGTMs

September 8, 2023
Author(s)
Amanda Bayless, Sandra Da Silva, William Davis, Abraham Kuri Cruz, Tracey Johnston, Stephanie Servetas, Paulina Piotrowski
The gut microbiome plays a critical role in a vast and disparate set of health and disease states, including cancer and obesity. Human fecal is a complex mixture including microbes, proteins, undigested plant matter and fat content according to the diet

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

January 24, 2022
Author(s)
Rebecca Schugar, Christy Gliniak, Lucas Osborn, William Massey, Naseer Sangwan, Anthony Horak, Rakhee Banerjee, Danny Orabi, Robert Helsley, Amanda Brown, Amy Burrows, Chelsea Finney, Kevin Fung, Frederick Allen, Daniel Ferguson, Anthony Gromovsky, Chase Neumann, Kendall Cook, Amy McMillan, Jennifer Buffa, James Anderson, Margarete Mehrabian, Maryam Goudarzi, Belinda Willard, Tytus Mak, Andrew Armstrong, Garth Swanson, Ali Keshavarzian, Jose Carlos Garcia-Garcia, Zeneng Wang, Aldons Lusis, Stanley Hazen, Mark Brown
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO)

An assessment of US microbiome research

September 23, 2021
Author(s)
Scott Jackson
Genome-enabled technologies have supported a dramatic increase in our ability to study microbial communities in environments and hosts. Taking stock of previously funded microbiome research can help to identify common themes, under-represented areas and

Current Explorations of Nutrition and the Gut Microbiome: A Systematic Review

September 23, 2021
Author(s)
Scott Jackson, Leigh A. Frame, Elise Costas
Background The ability to measure and describe the microbiome has led to a surge in information about the gut microbiome and its role in health and disease. The relationship between nutrition and the gut microbiome is central, as the diet is a source of

THE GUT MICROBIOME AND XENOBIOTICS: IDENTIFYING KNOWLEDGE GAPS

July 1, 2020
Author(s)
Vicki L. Sutherland, Charlene A. McQueen, donna Mendrick, donna gulezian, Carl Cerniglia, Steven Foley, Samuel Forry, Sangeeta Khare, Xue Liang, Jose E. Manautou, Donald Tweedie, howard young, Alexander Aleksenkyo, frank burns, Rod Dietert, Katherine Karberg, alan wilson, connie chen
There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, the Health and Environmental Sciences Institute (HESI) held a workshop, "The Gut

Report from the Winter Mid-Atlantic Microbiome Meet-up on Biodefense and Pathogen Detection, College Park, MD January 10th, 2018

November 5, 2018
Author(s)
Jacquelyn S. Meisel, Daniel Nasko, Brian Brubach, Victoria Cepeda Espinoza, Jessica Chopyk, Hector Corrada Bravo, Marcus Fedarko, Jay Ghurye, Kiran Javkar, Nathan D. Olson, Nidhi Shah, Sarah M. Allard, Adam L. Bazinet, Nichloas H. Bergman, Alexis Brown, Greg Caporaso, Sean Conlan, Jocelyn DiRuggiero, Samuel Forry, Nur A. Hasan, John Julias, Paul M. Luethy, Donald K. Milton, Brian Ondov, Sarah Preheim, Tara O'Toole, Stephanie Rogers, M.J. Rosovitz, Eric G. Sakowski, Nils O. Schliebs, Daniel D. Sommer, Krista Ternus, German Uritskiy, Sean X. Zhang, Mihai Pop, Todd Treangen
The Mid-Atlantic Microbiome Meet-up (M3) organization held its fourth meeting on January 10, 2018 in College Park, Maryland. M3 brings together academic, government, and industry groups in the broadly-defined mid-Atlantic region to share ideas and develop

Metagenomic assembly through the lens of validation: a review of recent advances in assessing and improving the quality of genes and genomes assembled from metagenomes.

August 6, 2017
Author(s)
Nathanael Olson, Chris M. Hill, Vistoria Cepeda-Espinoza, Jay Ghurye, Sergey Koren, Todd J. Treangen, Mihai Pop
Metagenomic samples are snapshots of complex ecosystems at work. These samples often involve hundreds of bacteria from known and unknown species, contain multiple strain variants, and vary greatly both within and across environments. Many microbes found in

Performing Skin Microbiome Research: A Method to the Madness

March 1, 2017
Author(s)
Heidi H. Kong, Bjorn Andersson, Thomas Clavel, John E. Common, Scott Jackson, Nathanael Olson, Julia Segre, Claudia Traidl-Hoffman
Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis. The need for common
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