THE GUT MICROBIOME AND XENOBIOTICS: IDENTIFYING KNOWLEDGE GAPS

Published

July 1, 2020

Author(s)

Vicki L. Sutherland, Charlene A. McQueen, donna Mendrick, donna gulezian, Carl Cerniglia, Steven Foley, Samuel Forry, Sangeeta Khare, Xue Liang, Jose E. Manautou, Donald Tweedie, howard young, Alexander Aleksenkyo, frank burns, Rod Dietert, Katherine Karberg, alan wilson, connie chen

Abstract

There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, the Health and Environmental Sciences Institute (HESI) held a workshop, "The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity" (https://hesiglobal.org/event/the-gut-microbiome-workshop) to identify data gaps in determining how gut microbiome alterations may affect human health. Speakers and stakeholders from academia, government and industry addressed multiple topics including the current science on the gut microbiome, dysbiosis, endogenous and exogenous metabolites, biomarkers and model systems. The workshop presentations and breakout group discussions formed the basis for identifying data gaps and research needs. Two critical issues that emerged were defining the composition and function of a healthy microbiome and developing standards for models, methods and analysis in order to increase the ability to compare and replicate studies. A series of key recommendations were formulated to focus efforts to further understanding of host-microbiome interactions and the consequences of exposure to xenobiotics as well as identifying biomarkers of microbiome-driven disease and toxicity.

Citation

Toxicological Sciences

Pub Type

Journals

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https://doi.org/10.1093/toxsci/kfaa060

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Keywords

gut microbiome, xenobiotics, human health

Citation

Sutherland, V. , McQueen, C. , Mendrick, D. , gulezian, D. , Cerniglia, C. , Foley, S. , Forry, S. , Khare, S. , Liang, X. , Manautou, J. , Tweedie, D. , young, H. , Aleksenkyo, A. , burns, F. , Dietert, R. , Karberg, K. , wilson, A. and chen, C. (2020), THE GUT MICROBIOME AND XENOBIOTICS: IDENTIFYING KNOWLEDGE GAPS, Toxicological Sciences, [online], https://doi.org/10.1093/toxsci/kfaa060, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=928598 (Accessed May 26, 2026)

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