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One may measure the kinetic rate constants associated with biochemical reactions using an optical biosensor: an instrument in which ligand molecules are convected through a flow cell over a surface to which receptors are immobilized. If there are multiple
Peter O. Denno, Yan Lu, Paul Witherell, Sundar Krishnamurty, Ian Grosse, Douglas Eddy
Recent studies have shown advantages to utilizing metamodeling techniques to mimic, analyze, and optimize system input-output relationships in Additive Manufacturing (AM). This paper addresses a key challenge in applying such metamodeling methods, namely
Andreas Tolk, John Fowler, Guodong Shao, Enver Yucesan
In December of 2017, the Winter Simulation Conference (WSC) celebrates its 50th anniversary. Among the special events planned to commemorate this milestone will be a track highlighting the history and fundamental contributions these conferences have made
To develop effective control optimization strategies for managing residential electricity consumption in a smart grid environment, predictive algorithms are needed that are simple to implement, minimize custom configuration, and provide sufficient accuracy
Conrad E. Bock, Fatma Dandashi, Sanford Friedenthal, Natalie Harrison, Steven Jenkins, Leon McGinnis, Janos Sztipanovits, Adelinde Uhrmacher, Eric Weisel, Lin Zhang
Understanding and developing complex systems requires collaboration between individuals with widely varying expertise. Communication between these individuals is facilitated by conceptual models. Conceptual models are early stage artifacts that integrate
We adapt modulus of continuity estimates to the study of spectra of combinatorial graph Laplacians, as well as the Dirichlet spectra of certain weighted Laplacians. The latter case is equivalent to stoquastic Hamiltonians and is of current interest in both
Zhelun Chen, Jin Wen, Anthony J. Kearsley, Amanda Pertzborn
A robust and efficient nonlinear algebraic and differential equations solver is increasingly essential as the scale of dynamic building system simulation grows larger and the models employed become more complex. There are many factors affecting the
Parastoo Delgoshaei, Mark Austin, Amanda Pertzborn, Mohammad Heidarinejad, Vikas Chandan
State-of-the-art building simulation control methods incorporate physical constraints into their mathematical models, but omit implicit constraints associated with policies of operation and dependency relationships among rules representing those
Wenjie Xia, Jake Song, Cheol Jeong, David D. Hsu, Frederick R. Phelan Jr., Jack F. Douglas, Sinan Keten
A major challenge in soft matter science is the bottom-up prediction of the temperature- dependent behavior of amorphous glass-forming (GF) polymers. Coarse-grained (CG) models derived from atomistic simulation data offer chemical specificity and access to
Nathan Mahynski, Jeffrey R. Errington, Vincent K. Shen
We derive a method for extrapolating the grand canonical free energy landscape of a multicomponent fluid system from one temperature to another. Previously, we introduced this statistical mechanical framework for the case where kinetic energy contributions
Many biochemical reactions involve a stream of chemical reactants (ligand molecules) flowing over a surface to which other reactants (receptors) are confined. Scientists measure rate constants associated with these reactions in an optical biosensor: an
Many biochemical reactions in nature involve a stream of chemical reactants (ligand molecules) flowing over a surface to which other reactants (receptors) are confined. Scientists measure rate constants associated with these reactions in an optical
Ultra-wideband (UWB) signal processing is a technology with many features that could develop into advances in communication and information technology. The technology has tremendous potential, but also presents challenges to the signal processing community