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Displaying 676 - 700 of 848

Standards and Standardization of Molecular Diagnostics

August 15, 2005
Author(s)
J P. Jakupciak, C D. O'Connell
DNA has become a major target for clinical laboratory testing over the past 5 years, and RNA testing is emerging for infectious disease and gene expression (1). To normalize laboratory results across different technology platforms as well as between

Standards for Validation of Cancer Biomarkers

April 2, 2005
Author(s)
Catherine D. O'Connell, Donald H. Atha, J P. Jakupciak
Over the past 10 years, DNA testing to identify disease associated mutations and specific organisms, which represent public health and safety concerns, have become major targets for laboratory testing. RNA testing is also emerging for gene expression, both

Manipulating Cell Adhesion on Gradient Poly(2-Hydroxyethyl Methacrylate)-Grafted Surfaces

April 1, 2005
Author(s)
Ying Mei, Tao Wu, Chang Xu, K J. Langenbach, John T. Elliott, B D. Vogt, Kathryn L. Beers, Eric J. Amis, N Washburn
In this study, a simple and versatile method was developed to prepare the low grafting density initaitor gradient, which was combined with surface initiated atom transfer radical polymerizations (ATRP) to produce a well defined poly(2-hydroxyethyl

Oxidative DNA Damage: Induction, Repair and Significance

September 1, 2004
Author(s)
M D. Evans, Miral M. Dizdar, M S. Cooke
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intra-cellular signaling, and detrimental, modifying cellular bimolecules, accumulation of which has been associated with numerous diseases. Of

Epidemiology of Cancer: An Overview

July 26, 2004
Author(s)
H Rodriguez, D Case
Epidemiology is the study of how often diseases occur in different groups of people and why. Epidemiological information is used to plan and evaluate strategies to prevent illness and as a guide to the management of patients in whom disease has already

Local and Global Control Mechanisms in Allosteric Threonine Deaminase

June 1, 2004
Author(s)
David T. Gallagher, D Chinchilla, Herbert Lau, Edward Eisenstein
Allosteric and cooperative control signals were investigated in the tetrameric enzyme threonine deaminase. The tetramer consists of two dimers that associate at the x dyad. The structure pointed the way to use the Q175E mutation to create hybrid tetramers
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