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The evaluation of an autosomal SNP 12-plex assay

Published

Author(s)

Peter M. Vallone, Amy E. Decker, Michael D. Coble, John M. Butler

Abstract

SNPs have the potential to play a useful role in human identification testing. Small PCR amplicon sizes associated with SNP typing technologies make SNPs attractive for typing degraded DNA or other low copy number situations. SNP markers can be useful in combination with STRs for resolving complex paternity issues (e.g. incest), identifying victims of mass disasters where insufficient family references are available and possibly inferring population of origin. Important considerations for SNP markers are the larger number required to equal the discriminatory power compared to traditional STRs, their inability to resolve complex mixtures, issues related to databasing new loci and the availability of a standard analysis platform.
Citation
International Congress Series
Volume
1288

Keywords

SNP, Autosomal marker, Multiplex PCR, Allele specific primer extension, NIST

Citation

Vallone, P. , Decker, A. , Coble, M. and Butler, J. (2006), The evaluation of an autosomal SNP 12-plex assay, International Congress Series (Accessed July 21, 2024)

Issues

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Created April 1, 2006, Updated February 19, 2017