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Health

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Displaying 26 - 50 of 1612

Ensuring accuracy in the development and application of nucleic acid amplification tests (NAATs) for infectious disease

May 20, 2024
Author(s)
Jim Huggett, Denise O'Sullivan, Simon Cowen, Megan Cleveland, Jacob Moran-Gilad, Amanda Winter, Michael Messenger, Julian Braybrook
Diagnostic tests were heralded as crucial during the COVID-19 pandemic with most of the key methods using bioanalytical approaches. Bioanalytical techniques can be loosely described as methods that identify and quantify larger molecules (than conventional

Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-well Plate System Using Electron Paramagnetic Resonance Oxygen Imaging

May 1, 2024
Author(s)
Safa Hameed, Navin Viswakarma, Eliyas Siddiqui, Greta Babakhanova, Carl Simon Jr., Boris Epel, Mrignayani Kotecha
Cell viability is an essential measurement for cell therapy, tissue engineered medical products (TEMPs), drug development, and many other biological processes and products. These systems rely on viable, healthy, and functional cells to work as intended

Spatial Variation in Mercury Accumulation in Bottlenose Dolphins (Tursiops spp.) in Southeastern U.S.A.

April 30, 2024
Author(s)
Mackenzie Griffen, Colleen E. Bryan Sallee, Tara Cox, Brian Balmer, Russell Day, Laura Garcia Barcia, Antoinette Gorgone, Jeremy Kiszka, Jenny Litz, Robin Perrtree, Teri Rowles, Lori Schwacke, Randall Wells, Eric Zolman
Bottlenose dolphins (Tursiops spp.) inhabit bays, sounds, and estuaries (BSEs) throughout the southeast region of the U.S.A. and are sentinel species for human and ecosystem-level health. Dolphins are vulnerable to the bioaccumulation of contaminants

CCQM-P199: Interlaboratory comparability study of HIV-1 RNA copy number quantification

April 13, 2024
Author(s)
Alison Devonshire, Eloise Busby, Gerwyn Jones, Denise O'Sullivan, Ana Fernandez-Gonzalez, Sachie Shibayama, Shin-ichiro Fujii, Megumi Kato, John Emerson Leguizamon Guerrero, Claudia Patricia Tere Pena, Maria Mercedes Arias Cortes, Roberto Becht Flatschart, Marcelo Neves de Medeiros, Antonio Marcos Saraiva, Young-Kyung Bae, Inchul Yang, Hee-Bong Yoo, Alexandra Bogozalec Kosir, Mojca Milavec, Lianhua Dong, Chunyan Niu, Xia Wang, Phattaraporn Morris, Sasithon Temisak, Megan Cleveland, Peter Vallone, Daniel Burke, Michael Forbes-Smith, Jacob McLaughlin, Samreen Falak, Martin Hussels, Rainer Macdonald, Andreas Kummrow, Burhanettin Yalcinkaya, Sema Akyurek, Muslum Akgoz, Maxim Vonsky, Andrey Runov, Simon Cowen, Stephen Nyangoma, Stephen Ellison, Clare Morris, Neil Almond, Jim Huggett
RNA is measured for a range of applications including clinical virology, disease-related gene expression biomarkers, biotechnology, cell therapy (viral vectors) and vaccines. For applications measuring viruses with RNA genomes, such as clinical viral load

A Four-Grating Interferometer for X-Ray Multi-Contrast Imaging

March 24, 2024
Author(s)
Daniel Josell, Houxun Miao, James Williams, Jr.
Background: X-Ray multi-contrast imaging with gratings provides a practical method to detect the differential phase and dark-field contrast images in addition to the traditional X-ray absorption image in a laboratory or hospital environment. Systems have

Heart-on-a-Chip Systems: Disease Modeling and Drug Screening Applications

February 14, 2024
Author(s)
Derrick Butler, Darwin Reyes-Hernandez
Cardiovascular disease (CVD) is the leading cause of death worldwide, casting a substantial economic footprint and burdening the global healthcare system. Historically, pre-clinical CVD modeling and therapeutic screening has been performed using animal

Cybersecurity of Genomic Data

December 20, 2023
Author(s)
Ronald Pulivarti, Natalia Martin, Frederick R. Byers, Justin Wagner, Justin Zook, Samantha Maragh, Jennifer McDaniel, Kevin Wilson, Martin Wojtyniak, Brett Kreider, Ann-Marie France, Sallie Edwards, Tommy Morris, Jared Sheldon, Scott Ross, Phillip Whitlow
Genomic data has enabled the rapid growth of the U.S. bioeconomy and is valuable to the individual, industry, and government because it has multiple intrinsic properties that in combination make it different from other types of high value data which

Spatially-Dependent Model for Rods and Cones in the Retina

December 14, 2023
Author(s)
Daniel M. Anderson, Danielle Brager, Anthony J. Kearsley
We develop a mathematical model for photoreceptors in the retina. We focus on rod and cone outer segment dynamics and interactions with a nutrient source associated with the retinal pigment epithelium cells. Rod and cone densities (number per unit area of

Microfluidic Blood Separation: Key Technologies and Critical Figures of Merit

November 18, 2023
Author(s)
Karina Torres Castro, Katherine Acuna-Umana, Leonardo Lesser-Rojas, Darwin Reyes-Hernandez
Blood is a complex sample comprised mostly of plasma, red blood cells (RBCs), and other cells whose concentrations correlate to physiological or pathological health conditions. There are also many blood-circulating biomarkers, such as circulating tumor

Recommendations for setting a criterion and assessing commutability of sample materials used in external quality assessment/proficiency testing schemes

November 2, 2023
Author(s)
Sverre Sandberg, Pernille Fauskanger, Jesper Johansen, Thomas Keller, Jeffrey Budd, Neil Greenberg, robert rej, MAURO PANTEGHINI, VINCENT DELATOUR, Ferruccio Ceriotti, Liesbet Deprez, Johanna Camara, Finlay MacKenzie, Alicia Lyle, Eline van der Hagen, Chris Burns, W. Greg Miller
It is important for external quality assessment materials (EQAMs) to be commutable with clinical samples; i.e., they should behave like clinical samples when measured using end-user clinical laboratory in vitro diagnostic medical devices (IVD-MDs). Using

Monoclonal Antibodies as SARS-CoV-2 Serology Standards: Experimental Validation and Broader Implications for Correlates of Protection

October 28, 2023
Author(s)
Lili Wang, Paul Patrone, Anthony Kearsley, Jerilyn Izac, Adolfas Gaigalas, John Prostko, Hang Xie, Linhua Tian, Elzafir Elsheikh, Edward Kwee, Troy Kemp, Simon Jochum, Natalie Thornburg, Clifford McDonald, Adi Gundlapalli, Sheng Lin-Gibson
COVID-19 has highlighted the need for more accurate and reproducible measurements of humoral immunity, including antibody levels and neutralization potential, which are critical for diagnostics, seroprevalence estimates, and development of vaccines and

SARS-CoV-2 infection establishes an enhanced, stable, and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using highly restricted TCRs

October 23, 2023
Author(s)
Cecily Choy, Joseph Chen, Jiangyuan Li, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee Chia, Jingshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, An Yang, Osorio Meirelles, Wells Wu, Rong-Fong Chen, RICHARD WILLIS, Minoru Ko, Y-T Liu, Supriyo De, Brian Pierce, Luigi Ferrucci, josephine egan, Roy Mariuzza, Nan-ping Weng, David Travis Gallagher
We analyzed circulating CD8+ T cells recognizing six epitopes from the SARS-CoV-2 nucleocapsid (N) protein in HLA-A2+ unexposed and recovered COVID-19 patients using multi-color flow cytometry and scRNAseq. We found that SARS-CoV-2 infection slightly

Evaluation of 3D Curvature and Lead Stress of Transvenous Right Ventricular Leads: The Human Use Conditions Study (HUCS)

September 9, 2023
Author(s)
Jonathan Piccini, Tim Quinn, Lucas Koepke, James Dawson, Nicki Mara, Jason Santelli, Diane Muff, Jordan Savela, Alex Felber, Michael Friedrich, Jens Rump, Felix Tschentscher, Jake Benzing, Charles Swerdlow
Transvenous leads of cardiac implanted electronic device (CIED) systems are meant to last the life of the patient, but they are at risk for conductor fatigue fracture from applied alternating stress. This stress depends on lead design and use conditions

Quantitation and integrity evaluation of RNA genome in lentiviral vectors by direct reverse transcription-droplet digital PCR (direct RT-ddPCR)

September 2, 2023
Author(s)
Zhiyong He, Edward Kwee, Megan Cleveland, Kenneth Cole, Sheng Lin-Gibson, Hua-Jun He
Abstract Lentiviral vectors (LV) have proven to be powerful tools for stable gene delivery in both dividing and non-dividing cells. Approval of these LVs for use in clinical applications has been achieved by improvements in LV design. Critically important

National Institute of Standards and Technology Environmental Scan 2023: Societal and Technology Landscape to Inform Science and Technology Research

August 23, 2023
Author(s)
Ashley Boggs-Russell, Kerrianne Buchanan, David W. Griffith, Heather Evans, Dimitrios Meritis, Lisa Ng, Anna Sberegaeva, Michelle Stephens
The 2023 National Institute of Standards and Technology Environmental Scan provides an analysis of key external factors that could impact NIST and the fulfillment of its mission in coming years. The analyses were conducted through three separate lenses

Recommendations for Setting a Criterion for Assessing Commutability of Secondary Calibrator Certified Reference Materials

August 11, 2023
Author(s)
W. Greg Miller, Thomas Keller, Jeffrey Budd, Jesper Johansen, Mauro Panteghini, Neil Greenberg, Vincent Delatour, Ferruccio Ceriotti, Robert Rej, Johanna Camara, Liesbet Deprez, Finlay MacKenzie, Alicia Lyle, Eline van der Hagen, Chris Burns, Pernille Fauskanger, Sverre Sandberg
A secondary higher-order calibrator is required to be commutable with clinical samples to be suitable for use in the calibration hierarchy of an end-user clinical laboratory in vitro diagnostic medical device (IVD-MD). Commutability is a property of a
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