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Displaying 1 - 25 of 869

Standardizing a human TBMNK cell assay across instrument platforms: a new framework for producing high-quality, AI-ready reference dataset

September 28, 2026
Author(s)
Yu-Fen (Andrea) Wang, Huan-Yu Chen, Bor-Sheng Ko, Ningchun Xu, Nathan Dwarshuis, James Woods, Paul DeRose, Santosh Putta, Yu Max Qian, John Quinn, John Elliott, Virginia Litwin, Robert Hoffman, Sheng Lin-Gibson, Lili Wang
Introduction: Recent advances in regenerative medicine advanced therapies (RMAT) are revolutionizing health care by providing curative treatments for previously untreatable diseases. Flow cytometry assays have been used to measure critical quality

A collaborative study evaluating the detection of virus-infected cells by transcriptomic high-throughput sequencing

September 22, 2026
Author(s)
Noemie Deneyer, Pei-Ju Chin, Guillaume Bayon-Vicente, Pascale Beurdeley, Megan Cleveland, Anne-Sophie Colinet, Stephane Cruveiller, Marc Eloit, Shanaz Gilchrist, Noriko Hashiba, Christophe Lambert, Antonio Lembo, Ka-Wai Leong, Brandye Michaels, Sandrine Moreira, Reiko Nakashima, Simone Olgiati, Nasrin Salehi, Qinyu Sun, Kazuhisa Uchida, Oliver Vandeputte, Yuzhe Yuan, Keisuke Yusa, Valeria Maria Zanda, Arifa Khan
High-throughput sequencing (HTS) is an agnostic virus detection technology that can replace or supplement the conventional adventitious virus assays used for safety testing of biologics. Transcriptomic HTS is particularly suitable for the detection of

What's next for metabolomics?

September 17, 2026
Author(s)
Tracey Johnston, Corey Broeckling, Clary Clish, Valerie Copie, Arthur S. Edison, Ulrich Gunther, Ewy Mathe, Vanessa Phelan, Robert Powers, Daniel Raftery, Nichole Reisdorph, Dajana Vuckovic, David S Wishart, Elizabeth Want
Metabolomics has become a mainstream approach that examines the metabolic composition of biological systems in relation to their physiological and disease states. Using analytical techniques such as nuclear magnetic resonance spectroscopy and mass

Opioid sensing at point-of-need

July 29, 2026
Author(s)
Thinh Bui, Edward Sisco, Kyle Chapkin, Wenqi Zhu, Junyeob Song, Dhruv Forma, Anthony Kearsley, Henri Lezec
The opioid epidemic, headlined by synthetic fentanyl, is a growing international concern that has especially garnered great attention in the United States at all levels of government. As a federal agency, the National Institute of Technology (NIST) was

Interlaboratory Comparison with a Reference Measurement Procedure (RMP) for Determining 24,25-Dihydroxvitamin D3 in Human Serum using Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

April 28, 2026
Author(s)
Stephen Wise, Ekaterina Mineva, Christine Pfeiffer, Hubert Vesper, Etienne Cavalier, Stephenie Peters, Karen Galvin, Kevin Cashman, Andrew Norbert Hoofnagle, Hsuan-Chieh (Joyce) Liao, Emma Williams, Laura Briggs, Adam Kuszak, Grace Hahm, Johanna Camara
An interlaboratory comparison study was conducted among five laboratories for determination of 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] in human serum using liquid chromatography - tandem mass spectrometry (LC-MS/MS) methods. The Centers for Disease

Serum proteome of the Egyptian rousette bat (Rousettus aegyptiacus) reveals signatures of immunity, proteostasis, and metabolism

April 6, 2026
Author(s)
Brooke Genovese, Nistara Randhawa, Benjamin Neely, Gabriela Grigorean, Amy Schuh, Brian Amman, Jessica Elbert, Simon Anthony, Jonna Mazet, Jonathan Towner, Brian Bird
Bats are increasingly studied for their ability to coexist with diverse viruses of human health importance. While this focus has yielded insights into host–pathogen dynamics, baseline physiological data from healthy bats remain limited, constraining

Result harmonization in medical laboratories: accomplishments and challenges.

March 13, 2026
Author(s)
Tony Badrick, Ralf D. Josephs, Liesbet Deprez, Christa Cobbaert, VINCENT DELATOUR, Christian Vogl, Katleen Van Uytfanghe, Ashley Green, Sverre Sandberg
The Joint Committee for Traceability in Laboratory Medicine was established in 2002 in response to the implementation of the European Community Directive 98.79/EC on in vitro medical devices. The Committee consisted of representatives from the

Breast imaging with ultra-low field MRI

February 19, 2026
Author(s)
Sheng Shen, Neha Koonjoo, Friderike Longarino, Mansi Saksena, Torben Hornung, Stephen Ogier, Susu Yan, Thomas Bortfeld, Kathryn Keenan, Matthew Rosen

Functional Characterization and a Real-World Clinical Laboratory Pilot of the Foundation for the National Institutes of Health Circulating Tumor DNA Quality Control Materials

November 6, 2025
Author(s)
Cloud Paweletz, Thomas Forbes, Laura M Yee, Grace Heavey, Hua-Jun He, Zhiyong He, Dana Connors, Daniel Stetson, Susan Keating, Kenneth Cole, Li Chen, Rini Pauly, Caroline Sigman, Liang-Chun Liu, Qiang Gan, Yves Konigshofer, Russell Garlick, Ephrem Chin, Gary Kelloff, Mickey Williams, Robert McCormack, Chris Karlovich
Purpose We previously developed quality control materials (QCMs) to aid in the development of circulating tumor DNA (ctDNA) assays. In this study, we further characterize the performance of the QCMs relative to clinical samples. Methods QCMs were provided

From Crisis to Routine - Standardization of SARS-CoV-2 Genome Detection by Enhanced EQA Schemes in a Scientific Pandemic Network

May 24, 2025
Author(s)
Martin Kammel, Hans-Peter Grunert, Anika Zimmerman, Annemarie Martin, Vanessa Lindig, Samuel Samuleit, Ulf Duehring, Mechthild Adams-Bagusche, Dirk Sander, Hannah Zeichhardt, Christian Drosten, Victor Corman, Daniela Niemeyer, Sandra Ciesek, Holger Rabenau, Martin Obermeier, Robert Ehret, Rolf Kaiser, Jim Huggett, Denise O'Sullivan, Peter Vallone, Megan Cleveland, Samreen Falak, Andreas Kummrow, Esmeralda Valiente, Rainer Macdonald, Mojca Milavec, Sabine Goseberg, Silke Kappler, Natalie Weiss, Laura Vierbaum, Patricia Kaiser, Ingo Schellenberg, Heinz Zeichhardt
The outbreak of the COVID-19 pandemic led to a crisis situation in which diagnostic methods for the genome detection of the emerging SARS-CoV-2 were urgently needed from the beginning of 2020 for patient diagnostics, detection of infection chains and

NIST Special Publication 260 NIST.SP.260-256 Certification of Standard Reference Material(R)s 3672a & 3673a: Organic Contaminants in Smokers' Urine (Frozen) & Organic Contaminants in Non-Smokers' Urine (Frozen)

May 14, 2025
Author(s)
Ashley Russell, Carolyn Burdette, Johanna Camara, Nathanael Heckert, Jennifer Hoguet, Kevin Huncik, Jared Ragland, Elena Wood
Standard Reference Material (SRM) 3672a Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673a Organic Contaminants in Non-Smokers' Urine (Frozen) are intended for use in evaluating analytical methods for the determination of selected naturally

Interlaboratory Assessment of Candidate Reference Materials for Lentiviral Vector Copy Number and Integration Site Measurements

April 21, 2025
Author(s)
Hua-Jun He, Zhiyong He, Steven Lund, Barbara Paugh, Jennifer McDaniel, Justin Zook, Sierra Miller, Samantha Maragh, Simona Patange, Mahir Mohiuddin, Alessandro Tona, John Elliott, Kenneth Cole, Sheng Lin-Gibson
Reference materials are essential for accurately measuring integrated lentiviral vector (LV) copy number (VCN) and integration sites for the safety and efficacy of lentivirus-based gene therapy. We conducted an interlaboratory study on NIST candidate

Inhibition by 4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide) (TH5487) of the Activity of Human 8-Oxoguanine DNA Glycosylase-1 (OGG1) for the Excision of 2,6-Diamino-4-hydroxy-5-formamidopyrimidine, 4,6-Diamino-5-formamido

April 3, 2025
Author(s)
Pawel Jaruga, R. Stephen Lloyd, Michael Luzadder, Istvan Boldogh, M Miral Dizdar
DNA glycosylases of the base excision repair pathway have become clinically validated drug targets for treatment of several diseases. Human OGG1 (hOGG1) is specific for the removal of the highly mutagenic 8-oxoguanine (8-oxo-Gua) and 2,6-diamino-4-hydroxy

Structural Heart Abnormalities are Prevalent on the 12-lead ECG among Volunteer Firefighters

April 1, 2025
Author(s)
Alexander Bae, Chi-Ju Lai, Yichen Yu, Nicole Krupa, David Hostler, Wai Cheong Tam, Mary Carey, Wendy Brunner, Dillon Dzikowicz
Introduction: In the US, the most common cause of death among active-duty firefighters is sudden cardiac death (SCD). Underlying heart diseases are important propagator of ventricular tachyarrhythmias that cause SCD. The objective of this abstract is to

CCQM-P199b: Interlaboratory comparability study of SARS-CoV-2 RNA copy number quantification

March 27, 2025
Author(s)
Alison Devonshire, Eloise Busby, Gerwyn Jones, Denise O'Sullivan, Ana Fernandez-Gonzalez, Laura Hernandez-Hernandez, Xinhua Dai, Lianhua Dong, Chunyan Niu, Jie Xie, Xia Wang, Xiaoting Qiao, Xiang Fang, Clare Morris, Neil Almond, Megan Cleveland, Peter Vallone, Esther Castro Galvan, Melina Perez Urquiza, Mercedes Guadalupe Herrera Lopez, Arifa Khan, Sandra Fuentes, Elsa Baumeister, John Emerson Leguizamon Guerrero, Sergio Luis Davila Gonzalez, Andres Felipe Leon Torres, Aurea Folgueras-Flatschart, Marcelo Neves de Medeiros, Antonio Marcos Saraiva, Roberto Becht Flatschart, Carla Divieto, Mattia Pegoraro, Massimo Zucco, Laura Revel, Marco Mazzara, Philippe Corbisier, Gerhard Buttinger, Young-Kyung Bae, Alexandra Bogozalec Kosir, Mojca Milavec, Malcolm Hawkins, A. Pia Sanzone, Phattarapornn Morris, Sasithon Temisak, David Lynch, Jacob McLaughlin, Michael Forbes-Smith, Felicity Hall, Daniel Burke, Sachie Shibayama, Shin-ichiro Fujii, Megumi Kato, Samreen Falak, Rainer Macdonald, Andreas Kummrow, Andrey Komissarov, Sema Akyurek, Muslum Akgoz, Maxim Vonsky, Andrey Runov, Elena Kulyabina, Denis Rebrikov, Jim Huggett
RNA is the analyte targeted by nucleic acid amplification tests for SARS-CoV-2 virus, the causative agent of the COVID-19 pandemic. RNA concentration measured in respiratory specimens can vary by over nine orders of magnitude (1, 2). While RNA abundances

METROLOGY FOR MRI: THE FIELD YOU'VE NEVER HEARD OF

March 19, 2025
Author(s)
Kathryn Keenan, Stephen Russek, Matt Hall
Quantitative MRI has been an active area of research for decades and has produced a huge range of approaches with enormous potential for patient benefit. In many cases, however, there are challenges with reproducibility which has hampered clinical

Certification of Standard Reference Material(R) 965c Glucose in Frozen Human Serum

March 13, 2025
Author(s)
Amanda Bayless, William Davis, Elena Wood, Abraham Kuri Cruz, Johanna Camara, Blaza Toman, Komal Dahya, Katherine Earl, Chui Tse, Uliana Danilenko, Hubert Vesper
Standard Reference Material (SRM) 965c Glucose in Frozen Human Serum is intended for use in validating methods for the determination of glucose in human serum and plasma. A unit of SRM 965c consists of three ampoules each of four materials: Level 1, Level

Role of NEIL1 in genome maintenance

February 19, 2025
Author(s)
Amanda McCullough, Irina Minko, Michael Luzadder, Jamie Zuckerman, Pawel Jaruga, Vladimir Vartanian, M Miral Dizdar, R. Stephen Lloyd
Phylogenetic analyses of DNA glycosylases that function in the initiation step of base excision repair reveal a high degree of conservation within the genes encoding Nei-like DNA glycosylase 1 (NEIL1). In concert with other glycosylases, this enzyme is an

Impact of screening for HPV-positive oropharyngeal cancers: A microsimulation-based modeling study

February 6, 2025
Author(s)
Rebecca Landy, Gregory Haber, Barry Graubard, Carole Fakhry, Nicole Campos, Emily Burger, Li Cheung, Hormuzd Katki, Maura Gillison, Anil Chaturvedi
Purpose: We estimated the population-level impact of screening on morbidity and mortality of HPV16-positive oropharyngeal cancer among US men aged 45-79 years. Methods: We developed an individual-level, state-transition natural history microsimulation
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