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Comparing Two Analytical Workflows for Seized Drug Analysis of Synthetic Cannabinoids, Cathinones, and Opioids

October 25, 2021

Author(s)

Edward Sisco, Amber Burns, Elizabeth Schneider, Charles R. Miller, IV, Laurel Bobka

As the challenges faced by drug chemists continue to persist, due the presence of synthetic opioids, novel psychoactive substances, and other emerging drugs, laboratories are continuing to look for new analytical approaches or techniques to ease the

Comparing Two Analytical Workflows for Seized Drug Analysis of Synthetic Cannabinoids, Cathinones, and Opioids

October 25, 2021

Author(s)

Edward Sisco, Amber Burns, Elizabeth Schneider, Charles R. Miller, IV, Laurel Bobka

Comparing Two Analytical Workflows for Seized Drug Analysis of Synthetic Cannabinoids, Cathinones, and Opioids

October 25, 2021

Author(s)

Edward Sisco, Amber Burns, Elizabeth Schneider, Charles R. Miller, IV, Laurel Bobka

DART-MS Data Interpretation Tool and Other Resources for Seized Drug Analysis

October 21, 2021

Author(s)

Edward Sisco, Arun Moorthy

A Framework for the Development of a Targeted Gas Chromatography Mass Spectrometry (GC-MS) Method for the Analysis of Synthetic Cannabinoids

October 8, 2021

Author(s)

Edward Sisco, Amber Burns, Arun Moorthy

With the increased presence of novel psychoactive substances (NPSs) in casework, seized drug analysis has become more complex and challenging. To assist in addressing these challenges, a suite of targeted gas chromatography mass spectrometry (GC-MS)

Development and Evaluation of a Targeted Gas Chromatography Mass Spectrometry (GC-MS) Method for Analysis of Synthetic Cathinones

October 8, 2021

Author(s)

Edward Sisco, Amber Burns, Arun Moorthy

With the increased prevalence of novel psychoactive substances (NPSs), seized drug analysis has become more complex and challenging due, in part, to changing chemical structures and isomeric species. To assist in addressing these challenges a series of

Investigating the Transfer of Drug Particulate onto Evidence Packaging During Routine Case Analysis

October 8, 2021

Author(s)

Edward Sisco, Liz Robinson, Rebecca Mead, Charles R Miller

The presence of drug residue and drug background in a forensic context continues to be of interest for a variety of reasons ranging from its potential use as a means for presumptive identification to ensuring the safety and well-being of drug chemists

NIST/NIJ DART-MS Data Interpretation Tool User Manual

October 8, 2021

Author(s)

Edward Sisco, Arun Moorthy, Stephen Tennyson, Ruthmara Corzo

Screening and Confirmation of Seized Drugs Utilizing Portable Raman Spectroscopy (TacticID) and Direct Analysis in Real Time-Mass Spectrometry (DART-MS)

October 8, 2021

Author(s)

Travon Cooman, Colby E. Ott, Kourtney A. Dalzell, Amber Burns, Edward Sisco, Luis E. Arroyo

The continuous change of the drug landscape in the United States demands adaptation and incorporation of emerging analytical methods that preferably allow onsite screening but are also capable of supporting the analysis of seized drugs received at forensic

The min-max test: an objective method for discriminating mass spectra

October 8, 2021

Author(s)

Arun Moorthy, Edward Sisco

Development and Evaluation of a Synthetic Opioid Targeted Gas Chromatography Mass Spectrometry (GC-MS) Method

August 30, 2021

Author(s)

Edward Sisco, Amber Burns, Arun Moorthy

A method for the targeted confirmation of synthetic opioids and related compounds was developed and evaluated. Using an 11-component test solution a method was developed that focused on maximizing chromatographic separation and understanding the influence

Cannabis Quality Assurance Program: Exercise 1 Final Report

July 27, 2021

Author(s)

MARYAM ABDUL-RAHMAN, Melissa M. Phillips, Walter Brent Wilson

NIST launched a CannaQAP in 2020 to improve the comparability of the analytical measurements in forensic and Cannabis (hemp and marijuana) testing laboratories. CannaQAP is an interlaboratory study mechanism that is similar to a proficiency testing scheme

Open port sampling interface mass spectrometry of wipe-based explosives, oxidizers, and narcotics for trace contraband detection

July 19, 2021

Author(s)

Thomas P. Forbes, Jeffrey Lawrence, Changtong Hao, J Greg Gillen

Rapid screening for chemical traces of explosives and narcotics is widely used to support homeland security and law enforcement. These target compounds span a range of physicochemical properties from organic to inorganic, with preferential ionization

Confined DART-MS for rapid chemical analysis of electronic cigarette aerosols and spiked drugs

June 29, 2021

Author(s)

Thomas P. Forbes, Shannon Krauss

A confined direct analysis in a real time mass spectrometry (DART-MS) system and method were developed for coupling directly with commercial electronic cigarettes for rapid analysis without sample preparation. The system consisted of a confining heated

Analysis of Benzodiazepines by Thermal Desorption Direct Analysis in Real Time Mass Spectrometry (TD-DART-MS)

June 17, 2021

Author(s)

Edward Sisco, Sydney Jones, Ioan Marginean

Novel psychoactive substances (NPS) present a prominent and increasing concern for forensic laboratories across the country. Benzodiazepines, which are one class of NPS, have experienced a growing presence in the United States due, in part, to the

Creation and Release of an Updated NIST DART-MS Forensics Database

June 17, 2021

Author(s)

Edward Sisco, Arun Moorthy, Laura M. Watt

Facing increasing caseloads and an everchanging drug landscape, forensic laboratories have been implementing new analytical tools. Direct analysis in real time mass spectrometry (DART-MS) is often one of these tools because it provides a wealth of

Detection of Trace Drugs of Abuse in Baby Formula using Solid Phase Extraction Direct Analysis in Real Time Mass Spectrometry (SPE-DART-MS)

June 17, 2021

Author(s)

Laura M. Watt, Edward Sisco

The intentional or unintentional adulteration of baby formula with drugs of abuse is one of the many increasingly complex samples forensic chemists may have to analyze. This sample type presents a challenge because of a complex matrix that can mask the

Forensic Applications of DART-MS: A Review of Recent Literature

June 17, 2021

Author(s)

Edward Sisco, Thomas Forbes

The need for rapid chemical analyses and new analytical tools in forensic laboratories continues to grow due to case backlogs, difficult to analyze cases, and identification of previously unseen materials such as new psychoactive substances. To adapt to

The use of lateral flow immunoassays for the detection of fentanyl in seized drug samples and postmortem urine

June 17, 2021

Author(s)

Daniel J. Angelini, Tracey Biggs, Amber M. Prugh, Jessica A. Smith, Jennifer A. Hanburger, Bob Llano, Raquel Avelar, Angela Ellis, Brady Lusk, Abdallah Naanaa, Edward Sisco, Jennifer W. Sekowski

The opioid crisis has continued to progress in the United States and the rest of the world. As this crisis continues, there is a pressing need for a rapid and cost-effective method for detecting fentanyl. Recent studies have suggested that lateral flow

Net Weights: Visualizing and Quantifying their Contribution to Drug Background Levels in Forensic Laboratories

June 24, 2020

Author(s)

Edward R. Sisco, Matthew E. Staymates, Laura M. Watt

While the drug background in forensic laboratories has been quantified, the processes that most contribute to the background have not been extensively researched. This work presents both qualitative visualization and quantitative analysis of the spread of

An Approach for the Visualization of Particle Spread During the Handling and Analysis of a Drug Evidence

March 11, 2020

Author(s)

Edward R. Sisco, Matthew E. Staymates, Amber Burns

Recent work has shown that detectable levels of drugs exists on nearly all surfaces within the forensic laboratory especially within the drug chemistry unit. This is an expected occurrence due to the handling and opening of drug evidence that contains

Method for Evaluating Ion Mobility Spectrometers for Trace Detection of Fentanyl and Fentanyl- related Substances

November 8, 2019

Author(s)

Jennifer R. Verkouteren, Jeffrey Lawrence, R. Michael Verkouteren, Edward Sisco

Continuing efforts to combat the opioid crisis in the U.S. require technologies that can detect the presence of fentanyl and fentanyl-related substances for multiple applications, including law enforcement and border protection. Ion mobility spectrometry

Separation and detection of trace fentanyl from complex mixtures using gradient elution moving boundary electrophoresis

September 27, 2019

Author(s)

Shannon T. Krauss, Thomas Forbes, David Ross

The current opioid epidemic remains an ongoing challenge, exacerbated by the extreme potency of synthetic opioids (e.g., fentanyl and fentanyl analogues), leading to an increase in adulterated heroin-related deaths. The increasing prevalence of fentanyl

Whats in the Bag? Analysis of Exterior Drug Packaging by TD-DART-MS to Predict the Contents

September 13, 2019

Author(s)

Edward R. Sisco, Elizabeth L. Robinson, Amber Burns, Rebecca Mead

The need for a safe and reliable presumptive test for law enforcement, first responders, and laboratory personnel is critical in the era of dangerous synthetic opioids and other novel psychoactive substances. Obtaining this type of information without

A Multi-Laboratory Investigation of Drug Background Levels

September 9, 2019

Author(s)

Edward R. Sisco, Marcela N. Najarro

Identifying, quantifying, and analyzing the drug background in operational environments such as forensic laboratories is an emerging body of research. Understanding these levels can provide critical information to address issues like occupational exposure