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Chemistry

Analytical chemistry

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Published Date
Displaying 301 - 325 of 2098

Mass Spectral Library of Acylcarnitines Derived from Human Urine

April 8, 2020
Author(s)
Xinjian Yan, Sanford Markey, Ramesh Marupaka, Qian Dong, Brian T. Cooper, Yuri Mirokhin, William E. Wallace, Stephen Stein
We describe the creation of a mass spectral library of acylcarnitines and conjugated acylcarnitines from the LC–MS/MS analysis of six NIST urine reference materials. To recognize acylcarnitines, we conducted in-depth analyses of fragmentation patterns of

Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences

April 6, 2020
Author(s)
John E. Schiel, Coffman Jon, Bruno Marques, Griesbach Jan, Ambrose Williams, Gisela Ferreira, Rushd Khalaf, David Roush, Charles Haynes
Biopharmaceutical product and process development does not yet take advantage of predictive computational modeling to nearly the degree seen in industries based on smaller molecules. To assess and advance progress in this area, spirited coopetition was

Characterization of triacontyl (C-30) liquid chromatographic columns

March 15, 2020
Author(s)
Lane C. Sander, Catherine A. Rimmer, Walter B. Wilson
Differences in the performance characteristics of seventeen commercial C30 liquid chromatographic columns were studied for the separation of carotenoid isomers. A mixture consisting of nine xanthophyll and hydrocarbon carotenoids were separated under

NIST Reference Materials: Their Purpose and Their Future

March 15, 2020
Author(s)
Steven J. Choquette, David L. Duewer, Katherine E. Sharpless
The National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards, was established by the U.S. Congress in 1901 and charged with establishing a measurement foundation to facilitate U.S. and international commerce. This

Practical Guide for Inelastic Mean Free Paths, Effective Attenuation Lengths, Mean Escape Depths, and Information Depths in X-ray Photoelectron SpectroscopyInformation Depths in X-ray Photoelectron Spectroscopy

February 20, 2020
Author(s)
Cedric J. Powell
Information is provided on four terms that are used for different purposes in X-ray photoelectron spectroscopy (XPS): the inelastic mean free path (IMFP), the effective attenuation length (EAL), the mean escape depth (MED), and the information depth (ID)

New Insights into Female Humpback Whale (Megaptera novaeangliae) Reproductive Endocrinology Revealed by Steroid Hormone Profile Analysis

February 19, 2020
Author(s)
Greta Dalle Luche, Ashley Boggs, John Kucklick, Jasmin Gross, Darryl Hawker, Susan Bengston Nash
The blubber steroid hormone profiles of 52 female humpback whales migrating along the east coast of Australia were investigated for possible seasonal endocrinological changes associated with reproduction. Individuals were randomly sampled in southeast

Optimization of Confined DART-MS

February 14, 2020
Author(s)
Edward R. Sisco, Matthew E. Staymates, Thomas P. Forbes
The use of direct analysis in real time mass spectrometry (DART-MS) is seeing increased use in a number of fields, including forensic science, environmental monitoring, food safety, and healthcare. With the increased use, novel configurations have been

Low-temperature time-resolved phosphorescence excitation emission matrices for the analysis of phenanthro-thiophenes in chromatographic fractions of complex environmental extracts

February 6, 2020
Author(s)
Sadia Arif, Maha Al-Tameemi, Walter Brent Wilson, Stephen Wise, Fernando Barbosa Jr., Andres Campiglia
Polycyclic aromatic sulfur heterocycles (PASHs) are sulfur analogues of polycyclic aromatic hydrocarbons (PAHs) widely found in environmental samples exposed to oil contamination. Despite their potential carcinogenic and mutagenic properties, only few

Applying Planar, Patterned, Multimetallic Samples to Assess the Impact of Analysis Area in Surface-Chemical Analysis: results of a VAMAS Interlaboratory Comparison

February 3, 2020
Author(s)
Christina Passiu, WES Unger, P Rupper, L Gregoratti, M Amanti, P Zeller, C Malitesta, S Rella, SJ Spencer, A Shard, A Kim, Shinichiro N. Muramoto, M Engelhard, B Hagenhoff, B Bock, R Heuberger, P Dietrich, A Thissen, M Kjaervik, D Paul, J Newman, T Weimann, S Butefisch, ND Spencer, A Rossi
The lateral resolution of a surface-analysis instrument is commonly measured as one of the indicators of the quality of obtainable analytical results. Different methods exist to measure this quantity, and traditionally the employed method/reference sample

Quantifying protein aggregation kinetics using electrospray differential mobility analysis

January 5, 2020
Author(s)
Kaleb J. Duelge, Jeremie Parot, Vincent A. Hackley, Michael R. Zachariah
Protein aggregation is a significant concern in bioprocessing and end use applications. Here the thermal aggregation kinetics of bovine serum albumin (BSA) and α-chymotrypsinogen A (α- chymo) were measured over a range of concentrations and temperatures by

Development of an LC-APCI-MS Method for Determining Off-Flavor Compounds and its Application Towards Marine Recirculating Aquaculture System Monitoring and Evaluation of Aeration as a Depuration Approach

January 4, 2020
Author(s)
Mary Bedner, Keiko Saito
The off-flavor compounds geosmin and 2-methylisoborneol (2-MIB) are well-known to impact the quality of farmed freshwater fish species, but little is known about off-flavors in marine aquaculture. To begin addressing this knowledge gap, a method for the

Blubber steroid hormone profiles as indicators of physiological state in free-ranging common bottlenose dolphins (Tursiops truncatus)

December 31, 2019
Author(s)
Thomas M. Galligan, Ashley Boggs, Brian C. Balmer, Teresa Rowles, Cynthia Smith, Forrest Townsend, Randall Wells, Nicholas Kellar, Eric Zolman, Lori Schwacke
Assessing endocrine health in free-ranging marine mammals can be difficult due to limited access to blood samples, which is the most commonly used sample matrix for endocrine assessment in wildlife. Blubber contains steroid hormones and can be collected

The role of ICP-MS in Separation Science

December 17, 2019
Author(s)
Antonio R. Montoro Bustos
Since its introduction in the 1980s, inductively coupled plasma mass spectrometry (ICP-MS) has evolved to become arguably the most versatile and powerful technique for the elemental analysis of metals, metalloids and selected non-metals at (ultra-)trace
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