An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Tracey Schock, Madison Edwards, Cesar Marasco Jr, Tiago Sobreira, Christina Ferreira, Graham Cooks
The availability of standard samples for human tissues and biofluids is needed to support method validation for metabolomics and lipidomics studies and to facilitate inter-laboratory comparisons. Multiple reaction monitoring (MRM)-profiling is an
A confined direct analysis in a real time mass spectrometry (DART-MS) system and method were developed for coupling directly with commercial electronic cigarettes for rapid analysis without sample preparation. The system consisted of a confining heated
Aaron Goldfain, Christopher Yung, Kimberly Briggman, Jeeseong C. Hwang
The technique of phase contrast imaging, combined with tomographic reconstructions, can rapidly measure ultrasonic fields propagating in water, including ultrasonic fields with complex wavefront shapes, which are difficult to characterize with standard
Qian Dong, Xinjian Yan, Yuxue Liang, Sanford Markey, Sergey L. Sheetlin, Concepcion Remoroza, William E. Wallace, Stephen Stein
This work presents methods for identifying and then creating a mass spectral library for disulfide-linked peptides originating from the NISTmAb. Analysis involved both partially- reduced and non-reduced proteins under neutral and weakly basic conditions
Korth Elliott, Frank Delaglio, Mats Wikstrom, John Marino, Luke Arbogast
The one-dimensional (1D) diffusion edited proton NMR method, Protein Fingerprint by Lineshape Enhancement (PROFILE) has been demonstrated to be suitable for higher order structure (HOS) characterization of protein therapeutics including monoclonal
Facing increasing caseloads and an everchanging drug landscape, forensic laboratories have been implementing new analytical tools. Direct analysis in real time mass spectrometry (DART-MS) is often one of these tools because it provides a wealth of
Kyle Anderson, Kerry Scott, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens
This database gives hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, FcγR1a (CD64)
Fatih Comert, Frank N. Heinrich, Ananda Chowdhury, Mason Schoeneck, Caitlin Darling, Kyle Anderson, M. Daben J. Libardo, Alfredo Angeles-Boza, Vitalii I. Silin, Myriam Cotten, Mihaela Mihailescu
In the search for novel broad‑spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing interest. Characterizing their biologically‑active conformations and minimum motifs for
Tracey Schock, Erik Andersson, Russell D. Day, Thierry M. Work, Paul Anderson, Cheryl M. Woodley
Coral growth anomalies (GAs) are tumor-like protrusions that impact both the coral skeleton and softs tissues and are detrimental to coral health. These lesions are increasingly found throughout the tropics and are commonly associated with high human
Amanda L. Bayless, Steven J. Christopher, Jennifer Ness, Colleen E. Bryan Sallee, Russell D. Day, Cheryl M. Woodley, C. Anna Toline
Chronic biological impairments of reef organisms have been documented at two national parks in St. Croix, USVI. Although several water quality parameters have been out of compliance with USVI water quality criteria, whether these parameters or other
We present a new collection of processing techniques, collectively "factorized Kramers-Kroenig and error correction" (fKK-EC), for (a) Raman signal extraction, (b) denoising, and (c) phase- and scale- error correction in coherent anti-Stokes Raman
Daniel J. Lum, Michael Mazurek, Alexander Mikhaylov, Kristen M. Parzuchowski, Ryan M. Wilson, Marcus Cicerone, Ralph Jimenez, Thomas Gerrits, Martin Stevens, Charles Camp
In this work, we demonstrate the preservation of time-energy entanglement of near-IR photons through thick biological media ( 1.55 mm) and tissue ( 235 um) at room temperature. Using a Franson-type interferometer, we demonstrate interferometric contrast of