Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Jacob Majikes (Assoc)

Jacob Majikes is a Research Scientist in the Microsystems and Nanotechnology Division. He received his B.S. and Ph.D. in materials science and engineering from North Carolina State University. His doctoral research focused on probing the folding/assembly of DNA origami nanostructures. Jacob is working with Alex Liddle to develop metrics to quantify the yield of discrete DNA nanostructures and to understand the effect of structure design on yield.

Selected Publications

  • Competitive annealing of multiple DNA origami: formation of chimeric origami, J.M. Majikes, J.A. Nash, T.H. Labean, New Journal of Physics, 18, 115001 (20016)
  • Search for effective chemical quenching to arrest molecular assembly and directly monitor DNA nanostructure formation, J.M. Majikes, J.A. Nash, T.H. Labean,, Nanoscale, 1637-1644 (2016)


DNA Origami Design: A How-To Tutorial

Jacob Majikes, James Alexander Liddle
While the design and assembly of DNA origami are straightforward, its relative novelty as a nanofabrication technique means that the tools and methods for

Patents (2018-Present)

Nucleic Acid Nanostructures

NIST Inventors
Jacob Majikes and Veronika Szalai
Embodiments of the present invention relate to methods and composition of a nucleic acid tile with addressable locations for placement of molecular species that can function as sensors, reporters, or enhancers of measurement systems. Embodiments of the present invention may also include a nucleic

Agile Nucleic Acid Sensor And Measuring A Biomarker

NIST Inventors
Kevin Kiesler , Alokik Kanwal , Anthony J. Kearsley , Erica Romsos , Peter M. Vallone , Jacob Majikes and Arvind Balijepalli
An agile nucleic acid sensor includes: a DNA switch; an analysis substrate in electrostatic communication with the DNA switch and that produces a biomarker electrical signal; a transduction member that receives the biomarker electrical signal and produces a transduction signal; a sensor counter

DNA Nanotechnology-Based Biomarker Measurement Platform

NIST Inventors
Arvind Balijepalli and Jacob Majikes
We developed a new approach that utilizes the precise addressability of DNA nanotechnology constructs to allow quantitative biomolecule sensing with high sensitivity, specificity and reproducibility. Novel approaches to engineering DNA nanostructures allow the realization of tunable gain elements
Created July 30, 2019, Updated July 5, 2023