David P. Hoogerheide

Publications

Restricting α-Synuclein Transport into Mitochondria by Inhibition of α-Synuclein-VDAC Complexation as a Potential Therapeutic Target for Parkinson's Disease Treatment

October 1, 2022

Author(s)

Megha Rajendran, Maria Queralt-Martin, Philip A. Gurnev, William M. Rosencrans, Amandine Rovini, Daniel Jacobs, Kaitlin Abrantes, David Hoogerheide, Sergey M. Bezrukov, Tatiana Rostovtseva

Involvement of alpha-synuclein (αSyn) in Parkinson's disease (PD) is complicated and difficult to trace on cellular and molecular levels. Recently we

Low-Background Neutron Reflectometry from Solid/Liquid Interfaces

February 1, 2022

Author(s)

David Hoogerheide, Joseph Dura, Brian B. Maranville, Charles F. Majkrzak

Liquid cells are an increasingly common sample environment for neutron reflectometry experiments and are critical for measuring the properties of materials at

Exploring Lipid-Dependent Conformations of Membrane-Bound α-Synuclein with the VDAC Nanopore

September 1, 2021

Author(s)

David Hoogerheide, Tatiana Rostovtseva, Sergey M. Bezrukov

Regulation of VDAC by α-Synuclein (αSyn) is a rich and instructive example of protein-protein interactions catalyzed by a lipid membrane surface. αSyn, a

Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering

August 24, 2021

Author(s)

Michael K. Thorsen, Alex Lai, Michelle W. Lee, David Hoogerheide, Gerard C. Wong, Jack H. Freed, Ekaterina Heldwein

During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This process is mediated by

pH Dependent Electrical Properties of the Inner- and Outer- Leaflets of Biomimetic Cell Membranes

July 15, 2021

Author(s)

Vitalii I. Silin, David Hoogerheide

Composition and asymmetry of lipid membranes provide a means for regulation of trans-membrane permeability of ions and small molecules. The pH dependence of

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2010-2013	Harvard University Postdoctoral Fellow (Jene Golovchenko)
2013-2015	NIH/NIST Joint Research Associateship (National Research Council)
2015-present	NIST Center for Neutron Research

2004	B. S., Physics and Chemistry	Western Michigan University
2006	A. M., Physics	Harvard University (advisor: Jene Golovchenko)
2010	Ph. D., Physics	Harvard University (advisor: Jene Golovchenko)

2010-2013	Harvard University Postdoctoral Fellow (Jene Golovchenko)
2013-2015	NIH/NIST Joint Research Associateship (National Research Council)
2015-present	NIST Center for Neutron Research

2004	B. S., Physics and Chemistry	Western Michigan University
2006	A. M., Physics	Harvard University (advisor: Jene Golovchenko)
2010	Ph. D., Physics	Harvard University (advisor: Jene Golovchenko)

David P. Hoogerheide (Fed)

Physicist

Publications

Restricting α-Synuclein Transport into Mitochondria by Inhibition of α-Synuclein-VDAC Complexation as a Potential Therapeutic Target for Parkinson's Disease Treatment

Low-Background Neutron Reflectometry from Solid/Liquid Interfaces

Exploring Lipid-Dependent Conformations of Membrane-Bound α-Synuclein with the VDAC Nanopore

Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering

pH Dependent Electrical Properties of the Inner- and Outer- Leaflets of Biomimetic Cell Membranes

Selected Publications