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Sean Lehman (Fed)
Physical Scientist
Sean Lehman works in the Bioprocess Measurements Group on issues of soft particle metrology using light scattering techniques. Current work involves the development of lipid nanoparticle reference materials and measurements of the same along with characterization of virus-like particles including AAV. Expertise involved particle measurements using asymmetric flow field flow fractionation (AF4) and-more recently-learning the technique of analytical ultracentrifugation (AUC). Prior to joining NIST, Sean spent time in 3D printed soft materials during his postdoctoral work at the University of Illinois, where he developed 3D printed plasmonic cell culture scaffolds. During his Ph.D. work he mostly focused on the synthesis, characterization, and applications of mesoporous silica nanoparticles with particular emphasis on magnetic spectroscopy of functionalized silica nanoparticles in aqueous environments.
Work Prior to NIST:
Publications:
1. Sean E. Lehman, Joselle M. McCracken, Lou Ann Miller, Sanjaya Jayalath, and Ralph G. Nuzzo*. Biocompliant Composite Au/pHEMA Plasmonic Scaffolds for 3D Cell Culture and Noninvasive Sensing of Cellular Metabolites. Adv. Healthcare Mater. 2021, 10, 2001040. (Special Issue: A Tribute to Professor George M. Whitesides. Inside Cover Art).
2. Maggie M. Potter/Mikayla A. Yoder, Aaron Petronico, Sean E. Lehman, Bruno G. Nicolau, Michael J. Enright, Megan Phelan, Junwen He, Harry A. Atwater, and Ralph G. Nuzzo*. Autonomous Light Management in Flexible Photoelectrochromic Films Integrating High Performance Silicon Solar Microcells. ACS Appl. Energy Mater. 2020, 3, 1540-1551.
3. Brittany M. Rauzan/Arif Z. Nelson, Sean E. Lehman, Randy H. Ewoldt*, and Ralph G. Nuzzo*. Particle-Free Emulsions for 3D Printing Elastomers. Adv. Funct. Mater. 2018, 28, 1707032. (Frontispiece.)
4. Brittany M. Rauzan, Sean E. Lehman, Joselle M. McCracken, Simon A. Rogers*, and Ralph G. Nuzzo*. A Printing-Centric Approach to the Electrostatic Modification of Polymer/Clay Composites for Use in 3D Direct-Ink Writing. Adv. Mater. Interfaces 2018,5, 1701579.
5. Somi Kang, Sean E. Lehman, Matthew V. Schulmerich, An-Phong Le, Tae-woo Lee, Stephen K. Gray, Rohit Bhargava, and Ralph G. Nuzzo*. Refractive Index Sensing and Surface-Enhanced Raman Spectroscopy Using Silver-Gold Layered Bimetallic Plasmonic Crystals. Beilstein Journal of Nanotechnology, 2017, 8, 2492-2503. (Part of Thematic Series: Nanoscale Patterning and Characterization)
6. Sean E. Lehman, Imali A. Mudunkotuwa, Vicki H. Grassian*, and Sarah C. Larsen*. Nano-Bio Interactions of Porous and Nonporous Silica Nanoparticles of Varied Surface Chemistry: A Structural, Kinetic, and Thermodynamic Study of Protein Adsorption from RPMI Culture Medium. Langmuir, 2016, 32, 731-742.
7. Sean E. Lehman, Angie S. Morris, Paul S. Mueller, Aliasger K. Salem, Vicki H. Grassian, and Sarah C. Larsen*. Silica Nanoparticle-Generated ROS as a Predictor of Cellular Toxicity: Mechanistic Insights and Safety by Design. Environ. Sci.: Nano 2016, 3, 56-66. (Journal Cover Art)
8. Angie S. Morris, Andrea Adamcakova-Dodd, Sean E. Lehman, Amaraporn Wongrakpanich, Peter S. Thorne, Sarah C. Larsen, and Aliasger K. Salem. Amine Modification of Nonporous Silica Nanoparticles Reduces Inflammatory Response Following Intratracheal Instillation in Murine Lungs. Toxicol. Lett. 2016, 241, 207-215.
9. Sean E. Lehman, Yulia Tataurova, Paul S. Mueller, S. V. Santhana Mariappan, and Sarah C. Larsen*. Ligand Characterization of Covalently-Functionalized Mesoporous Silica: An NMR Toolbox Approach. J. Phys. Chem. C 2014,118, 29943-29951.
10. Sean E. Lehman and Sarah C. Larsen*. Zeolite and Mesoporous Silica Nanomaterials: Greener Syntheses, Environmental Applications and Biological Toxicity. Environ. Sci.: Nano 2014, 1, 200-213. (Environmental Science: Nano HOT Article, Environmental Science: Nano 2014 Most Accessed Article)
Patent:
1. Mikayla A. Yoder, Maggie M. Potter, Aaron Petronico, Sean E. Lehman, Ralph G. Nuzzo. Autonomous Light Management System for a Window and Method of Controlling Light Transmission. U.S. Patent 2021/0116768 A1, April 22, 2021.
Awards
2015: Outstanding Student Poster Award; Colloid and Surface Chemistry Division, Spring 2015 National ACS Meeting in Denver, CO
2010: Achievement in Biosciences Prize-Oxford University Press; Department of Biology, Cornell College
2009: Mortar Board Senior Honor Society, Torch Chapter