David P. Hoogerheide

Instrument scientist for the CANDoR white beam reflectometer and a lead scientist on the ROADMAP project

Interests:

Applications of neutron scattering to biological materials
Novel platforms for neutron reflectivity measurements of membrane proteins
Structure-function relationships of membrane active peptides (ROADMAP)
Single-molecule methods for probing membrane proteins
Energy landscape modeling for nanopore capture of biopolymers

Selected Publications

Neutron Scattering for Structural Biology

June 1, 2020

Author(s)

David P. Hoogerheide, V. Trevor Forsyth, Katherine A. Brown

Structural Investigations of Membrane-Associated Proteins by Neutron Reflectometry

July 1, 2019

Author(s)

Rebecca Eells, David Hoogerheide, Paul A. Kienzle, Mathias Loesche, Charles Majkrzak, Frank Heinrich

Neutron reflectometry is a powerful technique for probing the structure of lipid bilayer membranes and membrane-associated proteins. Measurements of the...

Effect of a Post-Translational Modification Mimic on Protein Translocation through a Nanopore

April 27, 2020

Author(s)

David P. Hoogerheide, Philip A. Gurnev, Tatiana K. Rostovtseva, Sergey M. Bezrukov

Post-translational modifications (PTMs) of proteins are recognized as crucial components of cell signaling pathways through modulating folding, altering...

Structural Features and Lipid Binding Domain of Tubulin on Biomimetic Mitochondrial Membranes

April 18, 2017

Author(s)

David Paul Hoogerheide, Sergei Y. Noskov, Daniel Jacobs, Lucie Bergdoll, Vitalii Ivanovich Silin, David L. Worcester, Jeff Abramson, Hirsh Nanda, Tatiana K. Rostovtseva, Sergey M. Bezrukov

Amphitropic proteins, the subfamily of peripheral membrane proteins that interact directly with lipid bilayers, comprises members whose function depends on...

Publications

AI-Driven Antimicrobial Peptide Characterization Unveils Novel Motifs for Drug Design

December 29, 2025

Author(s)

Sarala Padi, Kinjal Mondal, David Hoogerheide, Frank N. Heinrich, Ella Mihailescu, Antonio Cardone, Jeffery Klauda

Antibiotics have been effectively developed to target and kill bacteria; however, the growing challenge of antimicrobial resistance (AR) has complicated the...

Poly-Arginine Tails and Helical Segments of Natural Antimicrobial Peptides Display Concerted Action at Membranes for Enhanced Antimicrobial Effects

July 8, 2025

Author(s)

Navleen Kaur, Kinjal Mondal, Megan Mitchell, Sarala N. Padi, Jeffery B. Klauda, Antonio Cardone, Frank N. Heinrich, Christina Harris, David Giles, Mary Rooney, Erik Watkins, Myriam Cotten, David Hoogerheide, Mihaela Mihailescu

Sequence motifs or patterns found in natural antimicrobial peptides (AMPs) have a great impact on their microbicidal activities. Here, through database...

Global and Local Effects in Lipid-Mediated Interactions between Peripheral and Integral Membrane Proteins.

May 30, 2025

Author(s)

Tatiana Rostovtseva, David Hoogerheide, William Milhizer, Sergey M. Bezrukov

Amphitropic proteins (APs) are a subfamily of water-soluble peripherally membrane-bound proteins that interact directly with the lipid membrane rather than with...

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2010-2013	Harvard University Postdoctoral Fellow (Jene Golovchenko)
2013-2015	NIH/NIST Joint Research Associateship (National Research Council)
2015-present	NIST Center for Neutron Research

2004	B. S., Physics and Chemistry	Western Michigan University
2006	A. M., Physics	Harvard University (advisor: Jene Golovchenko)
2010	Ph. D., Physics	Harvard University (advisor: Jene Golovchenko)

2010-2013	Harvard University Postdoctoral Fellow (Jene Golovchenko)
2013-2015	NIH/NIST Joint Research Associateship (National Research Council)
2015-present	NIST Center for Neutron Research

2004	B. S., Physics and Chemistry	Western Michigan University
2006	A. M., Physics	Harvard University (advisor: Jene Golovchenko)
2010	Ph. D., Physics	Harvard University (advisor: Jene Golovchenko)

David P. Hoogerheide (Fed)

Physicist

Selected Publications

Neutron Scattering for Structural Biology

Structural Investigations of Membrane-Associated Proteins by Neutron Reflectometry

Effect of a Post-Translational Modification Mimic on Protein Translocation through a Nanopore

Structural Features and Lipid Binding Domain of Tubulin on Biomimetic Mitochondrial Membranes

Publications

AI-Driven Antimicrobial Peptide Characterization Unveils Novel Motifs for Drug Design

Poly-Arginine Tails and Helical Segments of Natural Antimicrobial Peptides Display Concerted Action at Membranes for Enhanced Antimicrobial Effects

Global and Local Effects in Lipid-Mediated Interactions between Peripheral and Integral Membrane Proteins.