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Health

Dentistry

News and Updates

Projects and Programs

Chain orientation of polyethylene by polarization BCARS

3D Molecular Orientation Imaging

Ongoing
We have developed 3D orientation measurement techniques by analyzing polarization-dependent molecular vibrational signals based on infrared (IR) absorption [1,2] and coherent anti-Stokes Raman scattering (CARS) [3]. The two imaging modalities are complementary to each other: IR imaging broadly...
A schematic overview showing the distribution of the standardized samples to study participants, the use of standardized protocols for measurements, and standardized reporting of data back to NIST for analysis.

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing
To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2...

Advanced Spectral Analysis: Two-Dimensional Correlation Spectroscopy (2DCOS)

Ongoing
When a series of spectra are acquired from a sample as a function of temperature, pressure, electric field strength, concentration, or any experimental parameters, conventional spectral analysis is performed by monitoring the intensity change at a specific frequency. However, such a single frequency...

AI for Live Mouse Cancer Progression Detection

Ongoing
Overview NIST has partnered with the National Cancer Institute (NCI) at the National Institutes of Health (NIH) to study cellular characteristics and cellular movements in live mice that indicate the presence of tumors. NIST researchers have developed neural networks designed to automatically detect...

Publications

Standardizing a human TBMNK cell assay across instrument platforms: a new framework for producing high-quality, AI-ready reference dataset

Author(s)
Yu-Fen (Andrea) Wang, Huan-Yu Chen, Bor-Sheng Ko, Ningchun Xu, Nathan Dwarshuis, James Woods, Paul DeRose, Santosh Putta, Yu Max Qian, John Quinn, John Elliott, Virginia Litwin, Robert Hoffman, Sheng Lin-Gibson, Lili Wang
Introduction: Recent advances in regenerative medicine advanced therapies (RMAT) are revolutionizing health care by providing curative treatments for previously...

A collaborative study evaluating the detection of virus-infected cells by transcriptomic high-throughput sequencing

Author(s)
Noémie Deneyer, Pei-Ju Chin, Guillaume Bayon-Vicente, Pascale Beurdeley, Megan Cleveland, Anne-Sophie Colinet, Stephane Cruveiller, Marc Eloit, Shanaz Gilchrist, Noriko Hashiba, Christophe Lambert, Antonio Lembo, Ka-Wai Leong, Brandye Michaels, Sandrine Moreira, Reiko Nakashima, Simone Olgiati, Nasrin Salehi, Qinyu Sun, Kazuhisa Uchida, Oliver Vandeputte, Yuzhe Yuan, Keisuke Yusa, Valeria Maria Zanda, Arifa Khan
High-throughput sequencing (HTS) is an agnostic virus detection technology that can replace or supplement the conventional adventitious virus assays used for...

What's next for metabolomics?

Author(s)
Tracey Johnston, Corey Broeckling, Clary Clish, Valerie Copie, Arthur S. Edison, Ulrich Gunther, Ewy Mathe, Vanessa Phelan, Robert Powers, Daniel Raftery, Nichole Reisdorph, Dajana Vuckovic, David S Wishart, Elizabeth Want
Metabolomics has become a mainstream approach that examines the metabolic composition of biological systems in relation to their physiological and disease...

Opioid sensing at point-of-need

Author(s)
Thinh Bui, Edward Sisco, Kyle Chapkin, Wenqi Zhu, Junyeob Song, Dhruv Forma, Anthony Kearsley, Henri Lezec
The opioid epidemic, headlined by synthetic fentanyl, is a growing international concern that has especially garnered great attention in the United States at...

Software

Screenshot of NIST Mass and Fragment Calculator Software

NIST Mass and Fragment Calculator Software

The NIST Mass and Fragment Calculator is a program written in Visual Basic which calculates the mass of an input peptide or protein sequence along with m/z ions
isotope calc

Isotope Enrichment Calculator

The NIST Isotope Enrichment Calculator is a program written in Visual Basic which determines the percentage of 15N enrichment of stable isotope-labeled peptides
AutoDimer logo

AutoDimer

The web-based AutoDimer software was developed to rapidly screen previously selected PCR primers for primer-dimer and hairpin interactions in short DNA

Awards

Ram Sriram

Ram Sriram Named IEEE Fellow

Ram D. Sriram, Chief of ITL’s Software and Systems Division, has been named an Institute of Electrical and Electronics Engineers (IEEE) Fellow, effective January 1, 2017, for leadership in developing computational tools for healthcare enterprises...
Anne Plant

Anne Plant Elected AAAS Fellow

MML Division Chief Dr. Anne Plant has been elected to the rank of fellow of the American Association for the Advancement of Science (AAAS) by the AAAS Council. Plant was recognized for "distinguished contributions to the field of quantitative biology...
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