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Health

Dentistry

News and Updates

Projects and Programs

Chain orientation of polyethylene by polarization BCARS

3D Molecular Orientation Imaging

Ongoing
We have developed 3D orientation measurement techniques by analyzing polarization-dependent molecular vibrational signals based on infrared (IR) absorption [1,2] and coherent anti-Stokes Raman scattering (CARS) [3]. The two imaging modalities are complementary to each other: IR imaging broadly
A schematic overview showing the distribution of the standardized samples to study participants, the use of standardized protocols for measurements, and standardized reporting of data back to NIST for analysis.

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing
To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2

Advanced Spectral Analysis: Two-Dimensional Correlation Spectroscopy (2DCOS)

Ongoing
When a series of spectra are acquired from a sample as a function of temperature, pressure, electric field strength, concentration, or any experimental parameters, conventional spectral analysis is performed by monitoring the intensity change at a specific frequency. However, such a single frequency
Optical coherence tomography

Biofabrication of Tissue Engineered Constructs

Ongoing
OCT imaging was assessed using a model scaffold-cell system consisting of a polysaccharide-based hydrogel seeded with human Jurkat cells. Four test systems were used: hydrogel seeded with live cells, hydrogel seeded with heat-shocked or fixed dead cells and hydrogel without any cells. Time series

Publications

From Crisis to Routine - Standardization of SARS-CoV-2 Genome Detection by Enhanced EQA Schemes in a Scientific Pandemic Network

Author(s)
Martin Kammel, Hans-Peter Grunert, Anika Zimmerman, Annemarie Martin, Vanessa Lindig, Samuel Samuleit, Ulf Duehring, Mechthild Adams-Bagusche, Dirk Sander, Hannah Zeichhardt, Christian Drosten, Victor Corman, Daniela Niemeyer, Sandra Ciesek, Holger Rabenau, Martin Obermeier, Robert Ehret, Rolf Kaiser, Jim Huggett, Denise O'Sullivan, Peter Vallone, Megan Cleveland, Samreen Falak, Andreas Kummrow, Esmeralda Valiente, Rainer Macdonald, Mojca Milavec, Sabine Goseberg, Silke Kappler, Natalie Weiss, Laura Vierbaum, Patricia Kaiser, Ingo Schellenberg, Heinz Zeichhardt
The outbreak of the COVID-19 pandemic led to a crisis situation in which diagnostic methods for the genome detection of the emerging SARS-CoV-2 were urgently

NIST Special Publication 260 NIST.SP.260-256 Certification of Standard Reference Material®s 3672a & 3673a: Organic Contaminants in Smokers' Urine (Frozen) & Organic Contaminants in Non-Smokers' Urine (Frozen)

Author(s)
Ashley Russell, Carolyn Burdette, Johanna Camara, Nathanael Heckert, Jennifer Hoguet, Kevin Huncik, Jared Ragland, Elena Wood
Standard Reference Material (SRM) 3672a Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673a Organic Contaminants in Non-Smokers' Urine (Frozen) are

Interlaboratory Assessment of Candidate Reference Materials for Lentiviral Vector Copy Number and Integration Site Measurements

Author(s)
Hua-Jun He, Zhiyong He, Steven Lund, Barbara Paugh, Jennifer McDaniel, Justin Zook, Sierra Miller, Samantha Maragh, Simona Patange, Mahir Mohiuddin, Alessandro Tona, John Elliott, Kenneth Cole, Sheng Lin-Gibson
Reference materials are essential for accurately measuring integrated lentiviral vector (LV) copy number (VCN) and integration sites for the safety and efficacy

Inhibition by 4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide) (TH5487) of the Activity of Human 8-Oxoguanine DNA Glycosylase-1 (OGG1) for the Excision of 2,6-Diamino-4-hydroxy-5-formamidopyrimidine, 4,6-Diamino-5-formamido

Author(s)
Pawel Jaruga, R. Stephen Lloyd, Michael Luzadder, Istvan Boldogh, M Miral Dizdar
DNA glycosylases of the base excision repair pathway have become clinically validated drug targets for treatment of several diseases. Human OGG1 (hOGG1) is

Software

NIST Mass and Fragment Calculator Software

The NIST Mass and Fragment Calculator is a program written in Visual Basic which calculates the mass of an input peptide or protein sequence along with m/z ions
AutoDimer logo

AutoDimer

The web-based AutoDimer software was developed to rapidly screen previously selected PCR primers for primer-dimer and hairpin interactions in short DNA
isotope calc

Isotope Enrichment Calculator

The NIST Isotope Enrichment Calculator is a program written in Visual Basic which determines the percentage of 15N enrichment of stable isotope-labeled peptides

Awards

Ram Sriram

Ram Sriram Named IEEE Fellow

Ram D. Sriram, Chief of ITL’s Software and Systems Division, has been named an Institute of Electrical and Electronics Engineers (IEEE)
Anne Plant

Anne Plant Elected AAAS Fellow

MML Division Chief Dr. Anne Plant has been elected to the rank of fellow of the American Association for the Advancement of Science (AAAS)
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