Biochemical and Exposure Science Group

Projects and Programs

Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

Ongoing

NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species, to identify advantageous biological

Comparative Serum Proteomics Project

Ongoing

Initially the Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program will generate proteomic data from sera from 25 different species that

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years

Publications

Characterization of Reference Materials 8690 to 8693

February 13, 2023

Author(s)

Jessica Reiner, Benjamin Place, N. Alan Heckert, Katherine Peter, Alix Rodowa

The National Institute of Standards and Technology (NIST) Reference Materials (RMs) 8690 Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming

Toward an Integrated Machine Learning Model of a Proteomics Experiment

February 6, 2023

Author(s)

Ben Neely, Viktoria Dorfer, Lennart Martens, Isabell Bludau, Robbin Bouwmeester, Sven Degroeve, Eric Deutsch, Siegfried Gessulat, Tobias Rehfeldt, Lukas Käll, Veit Schwämmle, Samuel Payne, Tobias Schmidt, Pawel Palczynski, Julian Uszkoreit, Juan Antonio Vizcaino, Mathias Wilhelm, Magnus Palmblad

In recent years machine learning has made extensive progress in modeling many aspects of mass spectrometry data. We brought together proteomics data generators

ProteomicsML: An Online Platform for Community-Curated Datasets and Tutorials for Machine Learning in Proteomics

January 24, 2023

Author(s)

Tobias Rehfeldt, Ralf Gabriels, Robbin Bouwmeester, Siegfried Gessulat, Magnus Palmblad, Ben Neely, Yasset Perez-Riverol, Tobias Schmidt, Juan Antonio Vizcaíno, Eric Deutsch

Dataset acquisition and curation are often the hardest and most time-consuming parts of a machine learning endeavor. This is especially true for proteomics

Summary Report: Strategic Workshop on Management of PFAS in the Environment

November 30, 2022

Author(s)

Andrea Leeson, David Adamson, Lisa Alvarez-Cohen, Hunter Anderson, Frank Barranco, Christopher Bellona, Jens Blotevogel, Mark Brusseau, Michelle Crimi, Brian Crone, Rula Deeb, Dominic Di Toro, Craig Divine, Jennifer Field, Rajat Ghosh, Philip Gschwend, Jennifer Guelfo, Paul Hatzinger, Damian Helbling, Heather Henry, Christopher Higgins, Peter Jaffe, Detlef Knappe, Paul Koster van Groos, Linda Lee, Jinxia Liu, Shaily Mahendra, Carrie McDonough, Selma Mededovic, Marc Mills, Charles Newell, Carla Ng, Dung (Zoom) Nguyen, Bonnie Packer, Cara Patton, Graham Peaslee, Kurt Pennell, Jovan Popovic, Philip Potter, Joseph Quinnan, Maya Rabinowitz, Jessica L. Reiner, Stephen Richardson, Charles Schaefer, David Sedlak, Erin Shields, Jason Speicher, Thomas Speth, Timothy Strathmann, Hans Stroo, Timothy Thompson, Paul Tratnyek, Janice Willey

News and Updates

A large turtle lies on a rocky beach with surf in the background.

Scientists Identify Potential Bioindicators for Monitoring Plastic Pollution in the North Pacific Ocean

August 15, 2022

Key marine species can serve as bioindicators to measure how much plastic exists in different ocean regions.

A researcher stands on a boat reaching for a cable holding a grabber device.

NIST Releases Great Lakes Sediment Material for Measuring Organic Pollutants

November 23, 2021

People who live near the Great Lakes might go there to enjoy a swim or a boat ride. But if you’re visiting from the National Institute of Standards and

Gold-colored rectangle has circles and screws of various sizes.

Spotlight: One Small Step for SRM 610 Aboard the Mars Perseverance Rover

July 20, 2021

3, 2, 1 … blast off! One of NIST’s very own standard reference materials traveled through space and landed on the Red Planet in February as part of the National

NIST Researchers Use Novel Method to Understand the Molecular Underpinnings of a Tumorlike Disease Affecting Coral Reefs

July 9, 2021

Coral reefs are a favorite spot for scuba divers and are among the world’s most diverse ecosystems. For example, the Hawaiian coral reefs, known as the

Awards

2021 - Allen V. Astin Measurement Science Award---Lee Yu, Clay Davis, Savelas A. Rabb

For advancing the metrology of arsenic, and for the development of SI-traceable arsenic SRMs, needed to ensure human health and food safety worldwide.

2021 - Colleagues' Choice Award---Ashley Boggs

For outstanding advocacy, leadership and devotion to the forward progress of "One NIST" in science, equity, diversity and inclusion.

2021 - Distinguished Mentoring Award---Jennifer Lynch

For mentoring and inspiring generations of young scientists to pursue the research they love, helping and inspiring them every step of the way.

Katherine Peter Honored with Morgan Early Career Award

Dr. Peter is a National Research Council Postdoctoral Research Fellow and Research Chemist with the National Institute of Standards and

Press Coverage

NIST research biologist Jennifer M. Keller taking a blood sample from a loggerhead turtle

Study seeks origins of ghost nets that haunt Hawaii’s shores

Associated Press

May 27, 2021

A project to identify the fibers in discarded nets washed ashore can help policy makers address the sources of this pollution that devastates corals and

Microplastics are everywhere — but are they harmful?

Nature

May 4, 2021

"Researchers still can’t agree on whether pollutant-carrying microplastics are a significant problem, says Jennifer Lynch, a marine biologist affiliated with

A large polar bear is jumping from one block of ice to another.

Toxic chemicals banned 20 years ago finally disappearing from Arctic wildlife

Smithsonian

September 6, 2018

NIST measurements helped to demonstrate that concentrations of chemicals phased out according to the Stockholm Convention have decreased in Arctic wildlife.

Larval fish are eating microplastics in the Pacific Ocean

Oceanographic

"A study has found that plastic pieces outnumber larval fish numbers by seven to one in nursery waters off Hawaii."