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Projects/Programs

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Organizational Unit

Development of Enhanced mRNA Amplification Using Microfluidics

Completed

Intended Impact Tissue samples frequently contain multiple cell types. New methods (e.g. laser capture microdissection) enable the segregation of small quantities of individual cells and cell types, but the current methods to analyze global gene expression do not provide highly efficient profiling

Development of a First-Generation Community Resilience Assessment Methodology

Ongoing

Objective - By 2028, develop and disseminate a database of county level community resilience indicators, an inventory and analysis of published frameworks and indicators, and scientifically grounded guidance necessary to quantitatively assess community resilience over time for the nation, based on

Development of a First-Generation Community-Resilience Systems Model

Ongoing

Objective - By 2028, develop and test an efficient, interactive computer-based tool, Alternatives for Resilient Communities (ARC), to facilitate exploration of decision alternatives at the community scale for infrastructure systems (e.g., buildings, water, power, transportation) and their impacts on

Development and Implementation of the Community Resilience Planning Guides

Ongoing

Objective - By 2028, publish updated community resilience planning and decision-making guidance documents that are supported by multi-objective resilience planning & analysis tools, based on collaboration and engagement with end-user communities, professional organizations, and government agencies

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D exists in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D3 is produced in the body after sun exposure and is also the form used in most fortified foods. Dietary supplements may contain either vitamin D2 or D3. Measurement of vitamin D in foods and dietary

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Currently, NIST is investing in a new type of metrology laboratory that is focused on the unique reference material and high quality assay protocols that are needed in the regenerative medicine and biotechnology communities. The laboratory design is centered on automation that can set up 1000’s of

Figure contains text “Omics Data Quality” and human outline with arrows pointing from the human to the following specimen types: liver, serum, stool, plasma, urine. On either side of the human are analytical spectra and everything is surrounded by a decorative molecule structure circular border.

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

There is a significant need for tools to increase harmonization, comparability, and reproducibility between laboratories and/or studies, and to provide quality control of sample preparation and data analysis protocols utilized in untargeted omics analysis. Reference materials are being developed to

Development of Proteomics-Based Methods for Protein Quantification

Ongoing

Reference measurement procedures and standard reference materials help ensure that routine clinical assays provide accurate results across different laboratories and over time. Lists of such higher-order methods are published by the Joint Committee for Traceability in Laboratory Medicine (JCTLM)

Human Vitamin D Binding Protein in complex with 25-hydroxyvitamin D3

Development of Reference Materials and Methods for Vitamin D Binding Protein

Ongoing

Vitamin D is essential for bone health, and vitamin D deficiency can lead to rickets in children and osteomalacia (soft bones) in adults. Vitamin D status is typically monitored through measurement of the metabolite 25-hydroxyvitamin D [25(OH)D] in serum. Most 25(OH)D is tightly bound to its

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Ongoing

Kidney function can be evaluated by determining the glomerular filtration rate (GFR), which provides an estimate of how well the kidneys are removing waste and excess fluid from the blood. The GFR is not measured directly. Instead, a measurement of serum creatinine is performed, and this value is

Photograph of several clinical Standard Reference Materials showing labeled boxes, bottles, vials, ampoules and printed certificates.

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

Ongoing

Reference measurement procedures and standard reference materials help ensure accuracy and comparability of routine clinical assays. In addition, this work allows U.S. clinical diagnostic manufacturers to comply with the European Union directive regarding in-vitro diagnostic medical devices (IVD MD)

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Steroid hormones and thyroid hormones serve an essential function by regulating gene transcription. Improving the accuracy of clinical assays for hormones will improve diagnoses and result in earlier treatments. Therefore, reference methods for the measurement of steroid and thyroid hormones have

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

The clinical measurement of serum cardiac troponin I (cTnI) has become one of the most important tools in the diagnosis of acute myocardial infarction and myocardial damage. Unfortunately, considerable variability in clinical cTnI assay results is observed when comparing assays from different

NIST researcher pipetting solutions into 96-well plate for analysis

Development of Reference Methods and Reference Materials for Protein Biomarkers

Ongoing

Accuracy and reliability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. In one example, a clinical comparison among 13 commercial cardiac troponin I assay platforms

Development of Reference Methods and Reference Materials for Proteins

Ongoing

Accuracy and comparability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. A clinical comparison among 14 commercial assay platforms revealed more than 20-fold

Development of Serum-Based SRMs to Assess Nutritional Status

Ongoing

Vitamin deficiencies are generally considered rare in the U.S., but a growing body of evidence suggests that certain deficiencies may be more prevalent than originally thought. For example, it has been estimated that 10 % to 15 % of adults over the age of sixty are affected by vitamin B 12

Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing

Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of

Development of SRM 955c Toxic Elements in Caprine Blood

Completed

Intended Impact Over the last three decades, NIST, with support from the Centers for Disease Control (CDC), and in conjunction with the New York State Department of Health’s (NYSDOH) Wadsworth Center, has produced a number of frozen whole blood certified reference materials containing endogenous

Development of SRMs 2668 and 3668 for Accurate Assessment of Exposure to Toxic Elements and Anions

Completed

Toxic elements in the environment are a threat to public health and safety. Federal and state regulations have been issued to limit and abate the presence of toxic elements in the environment. The levels of toxic elements in the U.S. population are carefully monitored. NHANES is one of the federal

an infographic showing four proposed standards connecting as four joined puzzle pieces

Development of Standards to Support a Modular and Autonomous Laboratory Ecosystem

Ongoing

Autonomous experimentation (AE), or self-driving laboratories, combines AI and automation while leveraging human intuition and creativity to guide experiment campaigns. AE can reduce the time and resources needed to discover new materials by orders of magnitude and reduce the time-to-market for

Development of Standards for the World Meteorological Organization, Global Atmosphere Watch Program

Ongoing

Non-methane hydrocarbons (NMHCs) are emitted into the atmosphere by many biogenic and anthropogenic sources that include automobiles and other transportation vehicles, biomass burning, and oceans. In urban environments in particular NMHCs are important because they are precursors and contributors to

Development of surface functionalized engineered nanomaterials for biological applications

Ongoing

The main research theme is the design and implementation of novel surface functionalities on engineered nanomaterials, by chemical approach, for biological applications. This project involves (1) the creation of biocompatible nanomaterial systems as drug delivery templates, (2) characterization of

Device-level Anomaly fRamEwork (DARE)

Ongoing

A collaborative NIST team is taking a multi-disciplinary approach in cybersecurity, wireless communications, and machine learning. The DARE project leverages NIST's diligent approach and capabilities, including detailed use cases, design of experiments with rigorous multilayer measurements, and

Lattice constant for AI using various exchange-correlation functionals

DFT Benchmarking

Ongoing

Since its inception exactly 50 years ago this year, density-functional theory (DFT) has evolved from an exotic idea of physicists into the most-widely used tool for the computational prediction of materials’ structures and electronic, optical, magnetic, and mechanical properties. While DFT presents

DFT Repositories and Informatics

Ongoing

Historically, the printed article has served as the medium de rigueur for the dissemination of scientific information. This works well when the context and results of an experiment or theory fit on a few pages; however, it is insufficient as a publication medium for many computational studies. For

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Health
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-Manufacturing economics
-Manufacturing quality assurance
-Manufacturing systems design and analysis
-Monitoring, diagnostics and prognostics
-Process improvement
-Process measurement and control
-Product data
-Robotics in manufacturing
--Agility and adaptability
--Collaborative robots
--Dexterous grasping
--Manipulation
--Mobility and industrial autonomous vehicles
--Navigation / actuation / control
--Sensing and perception
-Supply chain
-Sustainable manufacturing
-Systems engineering
-Systems integration
-Technology commercialization
Materials
-Ceramics
-Composites
-Concrete / cement
-Materials characterization
--Composition and structure
--Mechanical properties
--Thermal properties
-Metals
-Modeling and computational material science
-Polymers
-Superconductors
Mathematics and statistics
-Experiment design
-Image and signal processing
-Modeling and simulation research
-Numerical methods and software
-Statistical analysis
-Uncertainty quantification
Metrology
-Amount of substance
-Dimensional metrology
-Electrical / electromagnetic metrology
-Flow metrology and rheology
-Force metrology
-Humidity metrology
-Ionizing radiation metrology
-Mass metrology
-Metric
-Optical / photometry / laser metrology
-Pressure and vacuum metrology
-Thermometry metrology
-Time and frequency metrology
-Weights and measures
Nanotechnology
-Nanobiotechnology
-Nanochemistry
-Nanoelectronics
-Nanofabrication / manufacturing
--Lithography
--Self-assembly
-Nanofluidics
-Nanomagnetics
-Nanomaterials
-Nanomechanics
-Nanometrology
-Nanophotonics
-Nanophysics
-Nanoplasmonics
Neutron research
Performance excellence
-Assessment tools and services
-Baldrige award
-Baldrige examiners
-Baldrige Framework and Criteria
-Best practices
-Leadership development
Physics
-Atomic / molecular / quantum
-Biological physics
-Condensed matter
-Electron physics
-Magnetics
-Nuclear physics
-Optical physics and communications
-Quantum information science
-Radiation
-Spectroscopy
-Thermodynamics
-Time and frequency
Public safety
-Chemical / Biological / Radiological / Nuclear / Explosives (CBRNE)
-First responder preparedness
-Law enforcement
-Public safety communications research
-Response robots
Resilience
-Community resilience
--Recovery
--Resilience metrics
-Disaster and failure studies
-Earthquake risk reduction
-Resilience economics
-Resilient materials
-Windstorm impact reduction
Standards
-Accreditation
-Calibration services
-Conformity assessment
-Documentary standards
-Frameworks
-Quality assurance
-Reference data
-Reference instruments
-Reference materials
-Standards education
Technology transfer
Transportation
-Aerospace
-Automotive