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Material Measurement Laboratory

Projects/Programs

Displaying 551 - 575 of 576

Transport Properties of Complex Particles and Polymers

Ongoing
Our approach is divided into several technical approaches: 1) Precise particle shape specification based on observation, 2) calculation of particle properties and 3) the calculation of the effect of particle shape on the properties of the polymer materials. Our computational webtool ZENO...
Exploded cross section diagram representing the simplified structure layers in a MOSFET transistor.

Transport Property Measurements for Semiconductors and Energy Materials

Ongoing
The image above is an exploded cross section diagram representing the simplified structure layers in a MOSFET transistor. Thermoreflectance (TR) laser-based measurement techniques, a key focus of this project, can measure the thermal properties of substrates, thin films, multilayer structures, and...
Online video tutorials education button in Laptop notebook computer screen. Play lesson concept. Vector illustration

Tutorials in Analytical Chemistry

Ongoing
Topic Links Laboratory Operations and Sample Processing Use of Analytical Balances Video N/A Volumetric Transfer of Liquids Video PowerPoint Determination of Liquid Density Video PowerPoint Preparation of Calibration Solutions Video PowerPoint Soxhlet Extractions Video PowerPoint Pressurized Fluid...
Illustration of three models with low, medium and high granularity.

Understanding Protein Solution Phase Behavior via Coarse-Grained Modeling

Ongoing
Intended Impact Because biological systems span a broad range of length and time scales, they cannot be studied effectively using conventional all-atom simulations. While hardware advances represent one route to improving the computational tractability of simulating biological systems, significant...

Unfolding and Aggregation of Therapeutic Proteins

Completed
A stable protein formulation is essential to the safety of mAb drugs. In particular, mAb drug solutions formulated at high concentrations can undergo various biophysical instabilities, such as aggregation and liquid-liquid phase separation. These undesired solution properties are primarily driven by...

Using AI to Determine Structure-Property Relations in Materials

Ongoing
The Material Measurement Lab at NIST employs artificial intelligence for the prediction and discovery of materials characteristics. Our applications of artificial intelligence (AI) accelerate materials research as well as help the community learn about AI's capabilities and gain confidence in...

Validating A.I. Pipelines for Analysis of Live Cell Image Data

Ongoing
We are exploring methods for very high-speed cell image data collection, which is enabling the repeated sampling of thousands of cells every 2 minutes. Rapid sampling allow us to observe dynamic processes in cells (such as cell division) on a relevant time scale. Such rates of sampling allows us to...
zif8_8UC

Validation of Density Functional Theory for Materials

Completed
A variety of systems will be considered in this work: Pure and alloy solids will be studied using periodic DFT methods with three distinct crystal structures that are relevant to the widely-used CALPHAD (Computer Coupling of Phase Diagrams and Thermochemistry) method. This study emphasizes the...
Breathalyzer

Vapor Sampling in the Field

Ongoing
Breath sampling of cannabis users. Several versions of breath collection devices are being marketed for the detection of THC (delta-9-tetrahydrocannabinol) in the breath of cannabis users. THC is not directly correlated to intoxication but may indicate recent smoking or vaping. THC and other...
Dvme-Schematic

Vapor Sampling to Support Public Safety and Forensics

Ongoing
Vapor pressures of unstable, reactive compounds. Over the last decade, our group has investigated a variety of low-volatility compounds including taggants (found in explosives), biofuels, terpenes and cannabinoids. Dynamic vapor microextraction (DVME), developed at NIST, is a small-volume dynamic...
Dart biopsy collection from a free-ranging bottlenose dolphin

Vertebrate Endocrine Metrology in Non-Traditional Matrices

Paused
NIST collaborates with stakeholders to develop techniques for measuring hormone levels as part of animal health assessment. The process of capturing and transporting animals before sampling can induce stress, which may alter the hormone levels in the bloodstream. Therefore, the collection of blood...
Figure with data points and lines, with the x axis labeled “unreliability” and the y axis labeled “error”.

Virtual Measurements

Ongoing
Intended Impact When engineering data, such as for reactive-chemical hazards, are obtained using quantum chemistry, the lack of associated uncertainties means that the reliability of the data is poorly known. Safety thus requires a skeptical view, often leading to expensive over-design. Objective...
Photograph of SRM 972a Vitamin D metabolites in Frozen Human Serum showing a labeled box and four bottles labeled level 1 to level 4.

Vitamin D Metabolites Quality Assurance Program (VitDQAP)

Completed
Interlaboratory comparison studies of the VitDQAP supported the reliability of vitamin D measurements, including determination of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, and 3- epi-25-hydroxyvitamin D3 in human serum and plasma. Results from the comparison studies helped participants to make...

Wastewater Surveillance

Ongoing
NIST is partnering with the Department of Homeland Security Science and Technology Directorate (DHS/S&T) to develop documentary standards and reference materials to support an enduring capability in wastewater surveillance. Ongoing activities include: Development of a research grade test material...

WebFF: Force-field repository for organic and soft materials

Ongoing
WebFF is an open and extensible force-field (FF) repository, designed to support the Materials Genome Initiative (MGI) for organic and related soft materials. The repository is built using the NIST Materials Data Curation System (MDCS) which supports ontology based database descriptions using XML...

WG1 Terminology

Ongoing
Standard(s) Under Development: ISO/WD TR 20386 Inventory of biotechnology-related terms US TAG WG1 Expert: Sumona Sarkar TAG Administrator: Clare Allocca

WG2 Biobanks and Bioresources

Ongoing
Standard(s) Under Development: ISO/AWI 20387 Biotechnology - Biobanking - General requirements for Biobanking US TAG WG2 Convenor: Nilsa Ramirez, MD, College of American Pathologists TAG Administrator: Clare Allocca

WG3 Analytical Methods

Ongoing
Standard(s) Under Development ISO/WD 20391-1: Biotechnology - Cell Counting – Part 1. General Guidance on Cell Counting Methods ISO/WD 20391-2: Biotechnology - Cell Counting – Part 2. Experimental Design and Statistical Analysis to Quantify Counting Method P erformance ISO/AWI 20395: Quality...

WG4 Bioprocessing

Ongoing
Standard(s) Under Development: ISO/AWI TS 20399-1: Raw materials control for bioprocessing -- Part 1: General definitions and requirements for quality control ISO/AWI TS 20399-2: Raw materials control for bioprocessing -- Part 2: Best practice guide for supplies ISO/AWI TS 20399-3: Raw materials...
example sample for tomography

X-Ray Computed Microtomography

Ongoing
Impact XCT gives information that cannot be obtained any other way from opaque materials and objects. It gives us an “eye inside” so that features, of a certain size range, can be seen. The Division’s XCT instruments can reconstruct 3D images with a voxel size down to about 0.5 micrometers, at the...
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