There is a project called NSRLquery developed by Rob Hansen of RedJack Security LLC, which has two subprojects: nsrlsvr, which provides a server that yields NSRL RDS information on request, and nsrllookup, a simple command-line application that queries the server.
There is a NSRL Hash Search Engine hosted at nsrl.hashsets.com which as of January 2014 supports searches via MD5, SHA1, or File Name.