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Gaithersburg

International Comparisons for Chemical Measurements

Because of NIST's role as the National Metrology Institute (NMI) in the U.S., the Chemical Sciences Division's measurement capabilities must be benchmarked

Measurements and Standards for Contaminants in Biological (Human) Materials

For the past 25 years NIST has developed a number of biological fluid and tissue Standard Reference Materials (SRMs) primarily for clinically important analytes

Development of Reference Methods and Reference Materials for Proteins

A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example

Microcalorimeter Detector

The NIST transition edge sensor microcalorimeter is energy dispersive x-ray spectrometer capable of ~5 eV resolution over a range of energies from hundreds to

Computational Biology Project

Biological research today is facilitated by automation that provides instrumentation control and data acquisition. Researchers are now able to quickly collect

WEBAPI

Many enterprises have become driven by digital data, including manufacturing, engineering, and scientific domains. With the ubiquity of Web browsers and Web

Nanocalorimetry

Nanocalorimetry using micromachined devices has the capability to provide quantitative data to support the development of advanced metal silicide metallizations

Measurement, Metrics, and Assurance

This Measurement, Metrics, and Assurance project focuses on measuring and assessing trustworthiness in software, systems and applications. It conducts research

Chemical/Biochemical Microsensor Science

There is a rapidly growing need for reliable sensor-based measurement technology which can quickly provide actionable outputs for on-site and local chemical

Development of a Collagen Fibril Reference Material for Reproducible Cell Response

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which cells are

Structural Databases

We are witnessing the emergence of a web based "data rich" era on chemical and biological compounds. In order to make significant advances in this "data rich"

Multiparametric Measurement and Analysis of Cell Behavior on Extracellular Matrices

Cell responses to their culture environment always involve more than one component. An understanding of the relation between the physical and chemical features

Quantitative, Cell-based Immunofluorescence Assays

Microscopy images of cells are often used in cell biology to qualitatively identify features of interest and to discern differences between treatments. Images

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical

Nanotechnologists Gain Powerful New Materials Probe

February 24, 2009

Researchers at the National Institute of Standards and Technology (NIST) and The Johns Hopkins University have constructed a unique tool for exploring the

Magnetism Governs Properties of Iron-Based Superconductors

March 24, 2009

Though a year has passed since the discovery of a new family of high-temperature superconductors, a viable explanation for the iron-based materials' unusual

NIST Research Collaboration Spies Galfenol's Inner Beauty Mark

March 24, 2009

The sonar on submarines may get far more sensitive ears in the near future thanks to a mysterious compound developed by the military. Developed over a decade

Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers

Proteins are of significant interest as potential indicators (biomarkers) of health or disease. Clinical methods employed to measure these analytes are often

Development of Proteomics-Based Methods for Protein Quantification

NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Chronic kidney disease (CKD) is a growing problem in the U.S., and current estimates suggest that more than 20 million Americans are affected by this disease

Photograph of several clinical Standard Reference Materials showing labeled boxes, bottles, vials, ampoules and printed certificates.

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

The accuracy of clinical diagnostic measurements is essential for reliable diagnosis and cost-effective treatment of disease. NIST's involvement in reference

Vitamin D Metabolites Quality Assurance Program (VitDQAP)

The National Institute of Standards and Technology (NIST) and the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) established a Vitamin

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and can