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Clinical diagnostics

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Fundamental Chemical Metrology

The Chemical Sciences Division serves as the Nation's reference laboratory for chemical compositional measurements and standards to enhance U.S. industry's

Publications

Assembly and annotation of an Ashkenazi human reference genome

Author(s)
Justin M. Zook, Justin M. Wagner, Nathanael D. Olson, Steven L. Salzberg, Alaina Shumate, Aleksey V. Zimin, Daniela Puiu, Mihaela Pertea, Marc Salit
Thousands of experiments and studies use the human reference genome as a resource each year. This single reference genome, GRCh38, is a mosaic created from a

IFCC working group recommendations for correction of bias caused by non-commutability of a certified reference material used in the calibration hierarchy of an end-user measurement procedure

Author(s)
Johanna Camara, W. Greg Miller, Jeffrey R. Budd, Neil Greenberg, Weykamp Cas, Harald Althaus, Heinz Schimmel, Mauro Panteghini, Vincent Delatour, Ferruccio Ceriotti, Thomas Keller, Douglas Hawkins, Robert Rej, Finlay MacKenzie, Elina van der Hagen, Hubert W. Vesper
Establishing metrological traceability to a matrix-based certified reference material (CRM) that has been validated to be commutable among a group of

Certification of a pregnancy-specific reference material for thyroid biomarkers, vitamin D, and nutritional trace elements in serum

Author(s)
Ashley S. Boggs-Russell, Lisa E. Kilpatrick, Carolyn Q. Burdette, Denise S. Tevis, Zachary A. Fultz, Michael A. Nelson, Jeff M. Jarrett, Stephen A. Wise, Brittany Kassim, Stephen E. Long
Background Concentrations of critical metabolites, hormones, and nutritional elements change significantly throughout pregnancy. Therefore, increased matrix

Software