Sander, L.
(2017),
Troubleshooting Liquid Chromatographic Instrumentation and Methods, Journal of Research (NIST JRES), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/jres.122.003
(Accessed October 20, 2025)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Troubleshooting Liquid Chromatographic Instrumentation and Methods
Published
Author(s)
Abstract
The ability to assess analytical performance is a fundamental component of measurement science. Ultimately, measurement quality depends on the proper function of instrumentation in combination with appropriate methods. Evidence of proper function is typically provided by the instrumentation, chromatograms, and the resulting data generated. Chromatographic peak shape is diagnostic of problems that originate with the instrumentation as well as the method and sample. Once a problem has been clearly identified, steps can be taken to resolve the issue. This presentation will describe common problems than may be encountered, with representative illustrations of the resulting effects on chromatographic performance.Citation
Journal of Research (NIST JRES) -
Volume
122
NIST Pub Series
Pub Type
NIST Pubs
Download Paper
Keywords
method development, troubleshooting, instrumentation, problem solving, system performance
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact [email protected].
Created January 12, 2017, Updated January 27, 2020