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Displaying 1 - 5 of 5

Spectroscopic and Spectrometric Approaches for Assessing the Composition of Embedded Metals in Tissues

November 24, 2020
Author(s)
Steven D. Hudson, Diane E. Smith, Todor Todorov, Adrian P. Defante, Jessica F. Hoffman, John F. Kalininch, Jose A. Centeno
Many medical devices contain metals that interface with the body. Additionally, embedded metal fragments from military wounds are typically not removed, to avoid the risk of morbidity associated with invasive surgery. The long-term health consequences of

Cutting to Measure the Elasticity and Fracture of Soft Gels

August 31, 2020
Author(s)
Teresa T. Duncan, Joel M. Sarapas, Adrian P. Defante, Kathryn Beers, Edwin Chan
The fracture properties of very soft and/or brittle materials are challenging to measure directly due to the limitations of existing fracture testing methods. To address this issue, we introduce a razorblade-initiated fracture test (RIFT) to measure the

The impact of the metal interface on the stability and quality of a therapeutic fusion protein

January 9, 2020
Author(s)
Adrian P. Defante, Steven D. Hudson, Cavan K. Kalonia, Emma Keegan, Steven Bishop, Paul Santacroce, Satish Hasige
Subvisible particle formation which occurs after the sterile filtration step of the fill/finish process is challenge that may occur during the development of biotherapeutics with complex molecular structures. Here, we show that a stainless-steel pump head