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Search Publications by: Edward Sisco (Fed)

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Displaying 1 - 25 of 87

Wound Causing Agents in the Illicit Drug Supply: Evidence from a Statewide Drug Checking Program

December 5, 2024
Author(s)
Emily Martin, Kristin Schneider, Edward Sisco, Meghan Appley, Margaret Rybak, Rae Elkasabany, Susan Sherman
Objectives To examine the prevalence of wound causing agents (xylazine, levamisole, medetomidine) in Maryland's illicit drug supply and co-occurrence with other substances. Methods Using data from Maryland's statewide drug checking program, Rapid Analysis

Drug Detection, Analysis, and Monitoring Workshop Report

August 30, 2024
Author(s)
Edward Sisco
This report is a summary of a workshop convened to capture the analytical and data challenges inherent to the detection, identification, and monitoring of illicit drugs in the United States – specifically highlighting current practices, challenges, and

National Institute on Drug Abuse Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids in Emergency, Hospital and Addiction Care Settings

March 16, 2024
Author(s)
Jeanmarie Perrone, Rachel Haroz, Joseph D'Orazio, Giacomo Gianotti, Jennifer Love, Matthew Salzman, Margaret Lowenstein, Ashish Thakar, Stephanie Klipp, Lisa Rae, Megan Reed, Edward Sisco, Rachel Wightman, Lewis Nelson
Used as a veterinary sedative and not approved for human use, xylazine has been increasingly linked with opioid overdose deaths in the United States. A growing number of people have been exposed to xylazine in the illicit opioid supply (especially fentanyl

On the challenge of unambiguous identification of fentanyl analogs: exploring measurement diversity using standard reference mass spectral libraries

July 11, 2023
Author(s)
Arun Moorthy, Edward Erisman, Anthony J. Kearsley, Yuxue Liang, Edward Sisco, William E. Wallace
Fentanyl analogs are a class of designer drugs that are particularly challenging to unambiguously identify due to the mass spectral and retention time similarities of unique compounds. In this paper, we use agglomerative hierarchical clustering to explore

Rapid Analysis of Drugs: A Tool to Detect Drug Overdose Spikes, Build Trust Among People Using Drugs and Reduce Overdoses - Maryland, November 2021 - August 2022

April 28, 2023
Author(s)
Erin Russell, Edward Sisco, Allison Thomson, Jasmine Lopes, Dana Heilman, Margaret Rybak, Malik Burnett, Meghan Appley, Matthew Gladden
Maryland overdose deaths increased 16%, to a record high of 2,912 deaths during the 12-month period from July 2020 to June 2021. Illicitly manufactured fentanyl and/or fentanyl analogs* contributed to 84% of these overdose deaths.† Timely public health

Development & Validation of A Rapid GC-MS Method for Seized Drug Screening

February 15, 2023
Author(s)
Madeline Bloom, Edward Sisco, Ira Lurie
Controlled substances are one of the most frequently analyzed types of evidence in forensic laboratories. An increase in frequency of seizures in recent years has necessitated a need for rapid screening techniques to decrease case backlogs and expedite

Rapid GC-MS as a Screening Tool for Forensic Fire Debris Analysis

July 6, 2022
Author(s)
Briana Capistran, Edward Sisco
Techniques developed for the screening of forensic samples can be useful for increasing sample throughput and decreasing backlog in forensic laboratories. One such technique, rapid gas chromatography mass spectrometry (GC-MS), allows for fast sample

A Template for the Validation of DART-MS for Qualitative Seized Drugs Analysis

March 10, 2022
Author(s)
Edward Sisco, Amber Burns, Elizabeth Schneider, Laurel Bobka, Ikenna Ikpeama
Direct analysis in real time mass spectrometry (DART-MS) is an increasingly employed tool for a wide range of forensic applications including seized drug analysis. A significant body of research surrounds DART-MS for the analysis of seized drugs and how it