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Displaying 1 - 25 of 25

Adaptive Peak Fitting for Isotope Analysis via Atom Probe Mass Spectrometry

July 30, 2021
Author(s)
Frederick Meisenkothen, Daniel Samarov, Mark McLean, Irina Kalish, Eric B. Steel
Atom probe tomography (APT) is an emergent characterization technique that has begun to see widespread use within the last 15 years. The technique offers the highest spatial resolution of any mass spectrometry technique for solid-state specimens, as well

Atom Probe Mass Spectrometry of Uranium Isotopic Reference Materials

July 22, 2020
Author(s)
Frederick Meisenkothen, Mark McLean, Irina Kalish, Daniel V. Samarov, Eric B. Steel
Atom probe tomography (APT) has the highest spatial resolution of any mass spectrometry technique, permitting chemically and isotopically resolved images to be recorded at near-atomic length scales. The technique also has a combined ionization efficiency

Exploring the Accuracy of Isotopic Analyses in Atom Probe Mass Spectrometry

May 21, 2020
Author(s)
Frederick Meisenkothen, Daniel V. Samarov, Irina Kalish, Eric B. Steel
Atom probe tomography (APT) can theoretically deliver accurate chemical and isotopic analyses at a high level of sensitivity, precision, and spatial resolution. However, empirical APT data often contain significant biases that lead to erroneous chemical

Using Replicates in Information Retrieval Evaluation

August 2, 2017
Author(s)
Ellen M. Voorhees, Daniel V. Samarov, Ian M. Soboroff
This paper explores a method for more accurately estimating the main effect of the system in a typical test-collection-based evaluation of information retrieval systems, and thus increasing the sensitivity of system comparisons. Randomly partitioning the

Quantifying Stability of Trace Explosives under Different Environmental Conditions

April 1, 2017
Author(s)
Edward R. Sisco, Marcela N. Najarro, Daniel V. Samarov, Jeffrey A. Lawrence
This work investigates the stability of trace deposits of six explosives (ETN, PETN, RDX, HMX, TNT, and Tetryl) to determine environmental stabilities and lifetimes. Explosives were inkjet printed directly onto PTFE coated fiberglass substrates and exposed

Label-free hyperspectral dark-field microscopy towards quantitative scatter imaging

March 27, 2017
Author(s)
Philip Cheney, David McClatchy III, Stephen Kanick, Paul Lemaillet, David W. Allen, Daniel Samarov, Brian Pogue, Jeeseong C. Hwang
A hyperspectral dark-field microscopy technique has been developed for imaging spatially distributed diffuse reflectance spectra from light-scattering samples. In this report, quantitative scatter spectroscopy was demonstrated with a uniform scattering

PEPR: Pipeline for Evaluating Prokaryotic References

April 1, 2016
Author(s)
Nathanael D. Olson, Justin M. Zook, Daniel V. Samarov, Scott A. Jackson, Marc L. Salit
The rapid adoption of microbial whole genome sequencing in public health, clinical testing, and forensic labo-ratories requires the use of validated and well characterized measurement processes. Reference materials thatare well characterized and

Coexposure to Phytoestrogens and Bisphenol a Mimics Estrogenic Effects in an Additive Manner

November 27, 2013
Author(s)
Anne Katchy, Caroline Pinto, Philip Jonsson, Trang Nguyen-Vu, Marchela Pandelova, Anne Riu, Karl-Werner Schramm, Daniel Samarov, Jan-Ake Gustafsson, Maria Bondesson, Cecilia Williams
Endocrine-disrupting chemicals (EDC) are abundant in our environment. A number of EDCs, including bisphenol A (BPA) can bind to the estrogen receptors, ERα and ERβ, and may contribute to estrogen-linked diseases such as breast cancer. Early-exposure is of

Hospital Readmission by Method of Data Collection

April 11, 2013
Author(s)
Elizabeth M. Hechenbleikner, Martin A. Makary, Daniel Samarov, Jennifer L. Bennett, Susan L. Gearhart, Jonathan E. Efron, Elizabeth C. Wick
Hospital readmissions are increasingly used as a metric of quality with non-payment planned for excess preventable rehospitalizations. Currently, data for pay-for-performance incentives are obtained from administrative sources however this information may

Hyperspectral Image Segmentation of the Common Bile Duct

March 8, 2013
Author(s)
Daniel V. Samarov, Eleanor Wehner, Roderich E. Schwarz, Karel Zuzak, Edward Livingston, Maritoni A. Litorja
Over the course of the last several years hyperspectral imaging (HSI) has seen increased usage in biomedicine. Within the medical field in particular HSI has been recognized as having the potential to make an immediate impact by reducing the risks and

An algorithm for finding clusters with a known distribution and its application to photon-number resolution using a superconducting transition-edge sensor

July 20, 2012
Author(s)
Zachary H. Levine, Thomas Gerrits, Alan L. Migdall, Daniel V. Samarov, Brice R. Calkins, Adriana E. Lita, Sae Woo Nam
Improving photon-number resolution of single-photon sensitive detectors is important for many applications, as is extending the range of such detectors. Here we seek improved resolution for a particular Superconducting Transition-Edge Sensor (TES) through

Algorithm Validation Using Multicolor Phantoms

May 9, 2012
Author(s)
Daniel V. Samarov, Matthew L. Clarke, Ji Y. Lee, David W. Allen, Maritoni A. Litorja, Jeeseong Hwang
We present a framework for hyperspectral image (HSI) analysis validation, specifically abundance fraction estimation based on HSI measurements of water soluble dye mixtures printed on microarray chips. In our work we focus on the performance of two

Designing Microarrays Phantoms for Hyperspectral Imaging Validation

May 9, 2012
Author(s)
Matthew L. Clarke, Ji Y. Lee, Daniel V. Samarov, David W. Allen, Maritoni A. Litorja, Ralph Nossal, Jeeseong Hwang
The simple design of custom-tailored microarrays for the characterization of hyperspectral imaging systems and analysis methods for biologically relevant samples. Individual and mixtures of dyes were printed on microscope slides and imaged by a

Validating the LASSO Algorithm by Unmixing Spectral Signatures in Multicolor Phantoms

February 1, 2012
Author(s)
Daniel V. Samarov, Matthew L. Clarke, Ji Y. Lee, David W. Allen, Maritoni A. Litorja, Jeeseong Hwang
As hyperspectral imaging (HSI) sees increased implementation into the biological and medical fields it becomes increasingly important that the algorithms being used to analyze the corresponding output be validated. While certainly important under any

Construction of a High Power OPO Laser system for Differential Absorption LIDAR

September 13, 2011
Author(s)
Kevin O. Douglass, Stephen E. Maxwell, David F. Plusquellic, Joseph T. Hodges, Roger D. van Zee, Daniel V. Samarov, James R. Whetstone
Our goal is to develop and characterize optical measurement technology to enable accurate quantification of greenhouse-gas emissions to meet the needs of industry and regulators. A 1064 nm pumped high energy optical parametric oscillator (OPO) operating

Assessing the shelf-life of a prototype reference material for product emissions testing

May 2, 2011
Author(s)
Cynthia H. Reed, Daniel V. Samarov, Dennis D. Leber, Zhe Liu, John Little
The National Institute of Standards and Technology (NIST) and Virginia Tech (VT) are developing a volatile organic compound (VOC) reference material to validate product emissions chamber testing. To verify the storage method of the material and determine

Developing a Diffusive Reference Material for VOC Emissions Testing: Pilot Interlaboratory Study

February 25, 2011
Author(s)
Cynthia H. Reed, Zhe Liu, Jennifer Benning, Steven Cox, Daniel V. Samarov, Dennis D. Leber, Al Hodgson, Stephany Mason, Doyun Won, John C. Little
In order to improve the reliability of product emissions testing and labeling, the National Institute of Standards and Technology (NIST) and Virginia Tech (VT) have created a program to develop reference materials with independently known emission rates

Characterization of Hyperspectral Imaging and Analysis via Microarray Printing of Dyes

February 22, 2011
Author(s)
Matthew L. Clarke, Maritoni A. Litorja, David W. Allen, Daniel V. Samarov, Jeeseong Hwang
The application of hyperspectral imaging requires rigorous characterization of the spatial and spectral imaging domains of the system. We present a microarray printing methodology for the testing of absorption or reflectance microscopy measurements. This

Analysis of Three Different Regression Models to Estimate the Ballistic Performance of New and Environmentally Conditioned Body Armor

February 14, 2011
Author(s)
Diane Mauchant, Michael A. Riley, Kirk D. Rice, Amanda L. Forster, Dennis D. Leber, Daniel V. Samarov
The performance standard for ballistic-resistant body armor published by the National Institute of Justice (NIJ), NIJ Standard 0101.06, recommends estimating the perforation performance of body armor by performing a statistical analysis on V50 ballistic

Limit of detection determination for censored samples.

January 11, 2011
Author(s)
Andrew L. Rukhin, Daniel V. Samarov
The problem of setting the limit of detection is considered for censored samples and heterogeneous errors. After formal definitions of the critical level and of the method detection limit, we introduce simplified maximum likelihood-type estimators. The