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Search Publications by: David Worcester (Assoc)

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Displaying 1 - 5 of 5

Lipid Nanodomains Change Ion Channel Function

August 22, 2017
Author(s)
Michael NMN Weinrich, David Worcester, Sergey M. Bezrukov
Signaling proteins and neurotransmitter receptors associate with cholesterol-rich fractions of cell membranes--lipid rafts. The different lipid environment in rafts can modulate protein function, but evidence for modulation of ion channels is lacking. Here

Halothane Changes the Domain Structure of a Binary Lipid Membrane

February 28, 2012
Author(s)
Michael Weinrich, Hirsh Nanda, David Worcester, Charles Majkrzak, Brian B. Maranville, Sergey M. Bezrukov
X-ray and neutron diffraction studies of model lipid raft membranes demonstrate that halothane at physiological concnetrations produces redistribution of lipids between domains of different lipid types identified by different lamellar-d-spacings and

Structure and Hydration of Membranes Embedded with Voltage-Sensing Domains

November 26, 2009
Author(s)
Dmitriy Krepkiy, Mihaela Mihailescu, J. Alfredo Freites, Eric V. Schow, David Worcester, Klaus Gawrisch, Douglas Tobias, Stephen White, Kenton J. Swartz
Despite the growing number of atomic-resolution membrane protein structures, direct structural information about proteins in their native membrane environment is scarce. This problem is particularly relevant in the case of the highly-charged S1-S4 voltage