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Lipid Nanodomains Change Ion Channel Function

Published

Author(s)

Michael NMN Weinrich, David Worcester, Sergey M. Bezrukov

Abstract

Signaling proteins and neurotransmitter receptors associate with cholesterol-rich fractions of cell membranes--lipid rafts. The different lipid environment in rafts can modulate protein function, but evidence for modulation of ion channels is lacking. Here we show in a cholesterol-rich model membrane system that lipid phase properties at the nanoscale directly affect the dissociation kinetics of the gramicidin dimer, a model ion channel.
Citation
Nanoscale
Volume
9
Issue
35

Keywords

Lipid Rafts, Lipid Domains, Ion Channels, Lipid Phases, Nanodomains

Citation

Weinrich, M. , Worcester, D. and Bezrukov, S. (2017), Lipid Nanodomains Change Ion Channel Function, Nanoscale, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=923018 (Accessed February 23, 2024)
Created August 21, 2017, Updated October 12, 2021