Weinrich, M.
, Worcester, D.
and Bezrukov, S.
(2017),
Lipid Nanodomains Change Ion Channel Function, Nanoscale, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=923018
(Accessed May 23, 2025)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Lipid Nanodomains Change Ion Channel Function
Published
Author(s)
, , Sergey M. Bezrukov
Abstract
Signaling proteins and neurotransmitter receptors associate with cholesterol-rich fractions of cell membranes--lipid rafts. The different lipid environment in rafts can modulate protein function, but evidence for modulation of ion channels is lacking. Here we show in a cholesterol-rich model membrane system that lipid phase properties at the nanoscale directly affect the dissociation kinetics of the gramicidin dimer, a model ion channel.Citation
Nanoscale
Volume
9
Issue
35
Pub Type
Journals
Download Paper
Keywords
Lipid Rafts, Lipid Domains, Ion Channels, Lipid Phases, Nanodomains
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact [email protected].
Created August 21, 2017, Updated October 12, 2021