NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.

Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.

U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Lipid Nanodomains Change Ion Channel Function

Published

Author(s)

Michael NMN Weinrich, David Worcester, Sergey M. Bezrukov

Abstract

Signaling proteins and neurotransmitter receptors associate with cholesterol-rich fractions of cell membranes--lipid rafts. The different lipid environment in rafts can modulate protein function, but evidence for modulation of ion channels is lacking. Here we show in a cholesterol-rich model membrane system that lipid phase properties at the nanoscale directly affect the dissociation kinetics of the gramicidin dimer, a model ion channel.
Citation
Nanoscale
Volume
9
Issue
35
Pub Type
Journals

Download Paper

Local Download

Keywords

Lipid Rafts, Lipid Domains, Ion Channels, Lipid Phases, Nanodomains
Neutron research

Citation

Weinrich, M. , Worcester, D. and Bezrukov, S. (2017), Lipid Nanodomains Change Ion Channel Function, Nanoscale, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=923018 (Accessed October 27, 2025)

Issues

If you have any questions about this publication or are having problems accessing it, please contact [email protected].

Created August 21, 2017, Updated October 12, 2021
Was this page helpful?