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Michael NMN Weinrich, David Worcester, Sergey M. Bezrukov
Abstract
Signaling proteins and neurotransmitter receptors associate with cholesterol-rich fractions of cell membranes--lipid rafts. The different lipid environment in rafts can modulate protein function, but evidence for modulation of ion channels is lacking. Here we show in a cholesterol-rich model membrane system that lipid phase properties at the nanoscale directly affect the dissociation kinetics of the gramicidin dimer, a model ion channel.
Weinrich, M.
, Worcester, D.
and Bezrukov, S.
(2017),
Lipid Nanodomains Change Ion Channel Function, Nanoscale, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=923018
(Accessed May 30, 2023)