Weinrich, M.
, Worcester, D.
and Bezrukov, S.
(2017),
Lipid Nanodomains Change Ion Channel Function, Nanoscale, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=923018
(Accessed May 30, 2023)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Lipid Nanodomains Change Ion Channel Function
Published
Author(s)
, , Sergey M. Bezrukov
Abstract
Signaling proteins and neurotransmitter receptors associate with cholesterol-rich fractions of cell membranes--lipid rafts. The different lipid environment in rafts can modulate protein function, but evidence for modulation of ion channels is lacking. Here we show in a cholesterol-rich model membrane system that lipid phase properties at the nanoscale directly affect the dissociation kinetics of the gramicidin dimer, a model ion channel.Citation
Nanoscale
Volume
9
Issue
35
Pub Type
Journals
Download Paper
Keywords
Lipid Rafts, Lipid Domains, Ion Channels, Lipid Phases, Nanodomains
Citation
Created August 21, 2017, Updated October 12, 2021