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Halothane Changes the Domain Structure of a Binary Lipid Membrane
Published
Author(s)
Michael Weinrich, Hirsh Nanda, David Worcester, Charles Majkrzak, Brian B. Maranville, Sergey M. Bezrukov
Abstract
X-ray and neutron diffraction studies of model lipid raft membranes demonstrate that halothane at physiological concnetrations produces redistribution of lipids between domains of different lipid types identified by different lamellar-d-spacings and isotope composition. In contrast, dichlorohexaflurocyclobutane, a fully halogenated non-anesthetic, does not produce significant phase redistribution. These finding demonstrate a specific effect of inhalational anesthetic on the mixing phase equilibria of complex lipid mixtures that mimic the complexity of real biological membranes.
Weinrich, M.
, Nanda, H.
, Worcester, D.
, Majkrzak, C.
, Maranville, B.
and Bezrukov, S.
(2012),
Halothane Changes the Domain Structure of a Binary Lipid Membrane, Langmuir, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=908734
(Accessed October 1, 2025)