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Halothane Changes the Domain Structure of a Binary Lipid Membrane

Published

Author(s)

Michael Weinrich, Hirsh Nanda, David Worcester, Charles Majkrzak, Brian B. Maranville, Sergey M. Bezrukov

Abstract

X-ray and neutron diffraction studies of model lipid raft membranes demonstrate that halothane at physiological concnetrations produces redistribution of lipids between domains of different lipid types identified by different lamellar-d-spacings and isotope composition. In contrast, dichlorohexaflurocyclobutane, a fully halogenated non-anesthetic, does not produce significant phase redistribution. These finding demonstrate a specific effect of inhalational anesthetic on the mixing phase equilibria of complex lipid mixtures that mimic the complexity of real biological membranes.
Citation
Langmuir
Volume
28

Keywords

Bilayer Membranes, Lipid Rafts, Lateral Phase Separation, Inhalation Anesthetics, Halothane, Neutron Diffraction, X-ray Diffraction

Citation

Weinrich, M. , Nanda, H. , Worcester, D. , Majkrzak, C. , Maranville, B. and Bezrukov, S. (2012), Halothane Changes the Domain Structure of a Binary Lipid Membrane, Langmuir, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=908734 (Accessed March 2, 2024)
Created February 27, 2012, Updated October 12, 2021