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Halothane Changes the Domain Structure of a Binary Lipid Membrane



Michael Weinrich, Hirsh Nanda, David Worcester, Charles Majkrzak, Brian B. Maranville, Sergey M. Bezrukov


X-ray and neutron diffraction studies of model lipid raft membranes demonstrate that halothane at physiological concnetrations produces redistribution of lipids between domains of different lipid types identified by different lamellar-d-spacings and isotope composition. In contrast, dichlorohexaflurocyclobutane, a fully halogenated non-anesthetic, does not produce significant phase redistribution. These finding demonstrate a specific effect of inhalational anesthetic on the mixing phase equilibria of complex lipid mixtures that mimic the complexity of real biological membranes.


Bilayer Membranes, Lipid Rafts, Lateral Phase Separation, Inhalation Anesthetics, Halothane, Neutron Diffraction, X-ray Diffraction


Weinrich, M. , Nanda, H. , Worcester, D. , Majkrzak, C. , Maranville, B. and Bezrukov, S. (2012), Halothane Changes the Domain Structure of a Binary Lipid Membrane, Langmuir, [online], (Accessed March 2, 2024)
Created February 27, 2012, Updated October 12, 2021