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Search Publications by: Frank Heinrich (Assoc)

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Displaying 26 - 40 of 40

Structural Features of Membrane-bound Glucocerebrosidase and a-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

January 9, 2015
Author(s)
Thai Leong Yap, Zhiping Jiang, Frank Heinrich, James M. Gruschus, Candace M. Pfefferkorn, Marilia Barros, Joseph E. Curtis, Ellen Sidransky, Jennifer C. Lee
Mutations in glucocerebrosidase (GCase), the enzyme deficient in Gaucher disease, are a common genetic risk factor for the development of Parkinson disease (PD) and related disorders, implicating the role of this lysosomal hydrolase in the disease etiology

Structure and Stability of Phospholipid Bilayers Hydrated by a Room-Temperature Ionic Liquid/Water Solution: a Neutron Reflectometry Study

October 23, 2014
Author(s)
Antonio Benedetto, Frank Heinrich, Miguel A. Gonzalez, Giovanna Fragneto, Erik Watkins, Pietro Ballone
Neutron reflectometry measurements (NR) have been carried out to probe the structure and stability of two model bio-membranes consisting of POPC and DMPC phospholipid bilayers hydrated by water solutions of two prototypical room-temperature ionic liquids

Membrane Association of the PTEN Tumor Suppressor: Molecular Details of the Protein-Membrane Complex from SPR Binding Studies and Neutron Reflection

April 10, 2012
Author(s)
Siddharth Shenoy, Prabhanshu Shekhar, Frank Heinrich, Maria-Claire Daou, Arne Gericke, Alonzo H. Ross, Mathias Loesche
The structure and function of the PTEN phosphatase is investigated by studying its membrance affinity and localization on in-plane fluid, thermally disordered synthetic membrane models. The membrane association of the protein depends strongly on membrane

Molecular Insights into a-Synuclein and Its N-terminal Peptides at the Membrane Interface

February 1, 2012
Author(s)
Candace M. Pfefferkorn, Frank Heinrich, Alexander J. Sodt, Alexander S. Malstev, Richard W. Pastor, Jennifer C. Lee
The role of phospholipids in modulating α-synuclein (α-syn) conformation is of great interest because α-syn aggregation is linked to Parkinson¿s disease. Using a sparsely tethered-bilayer composed of 1:1 molar ratio of 1-palmitoyl-2-oleoyl-sn-glycero-3

Coverage-Dependent Morphology of PEGylated Lysozyme Layers Adsorbed on Silica

January 4, 2012
Author(s)
Sheetal S. Pai, Frank Heinrich, Adam L. Canady, Todd M. Przybycien, Robert D. Tilton
Neutron reflection was used to characterize the adsorbed layer structure for lysozyme conjugated at the N-terminus with a single perdeuterated methoxy poly(ethylene glycol) chain at the silica/water interface. Adsorbed layers were produced with two

Phase-Sensitive Specular Neutron Reflectometry for Imaging the Nanometer Scale Compositional Depth profile of Thin-Film Materials

November 20, 2011
Author(s)
Brian Kirby, Paul A. Kienzle, Brian B. Maranville, Norman F. Berk, J. Krycka, Frank Heinrich, Charles Majkrzak
Neutron reflectometry is a powerful method for probing the molecular scale structure of both hard and soft condensed matter films. Moreover, the phase-sensitive methods which have been developed make it possible for specular neutron reflectometry to be
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