Publications

Displaying 26 - 39 of 39

Structure and Stability of Phospholipid Bilayers Hydrated by a Room-Temperature Ionic Liquid/Water Solution: a Neutron Reflectometry Study

October 23, 2014

Author(s)

Antonio Benedetto, Frank Heinrich, Miguel A. Gonzalez, Giovanna Fragneto, Erik Watkins, Pietro Ballone

Neutron reflectometry measurements (NR) have been carried out to probe the structure and stability of two model bio-membranes consisting of POPC and DMPC phospholipid bilayers hydrated by water solutions of two prototypical room-temperature ionic liquids

Zooming in on Disordered Systems: Neutron Reflection Studies of Proteins Associated with Fluid Membranes

September 1, 2014

Author(s)

Frank Heinrich, Peter M. Loesche

Neutron reflectometry (NR) is an emerging experimental technique for the structural characterization of proteins interacting with fluid bilayer membranes under conditions that mimic closely the cellular environment. Thus, cellular processes can be emulated

Myristoylation Restricts Orientation of the GRASP Domain on Membranes and Promotes Membrane Tethering

April 4, 2014

Author(s)

Frank N. Heinrich, Hirsh Nanda, Goh Haw Zan, Collin Bachert, Mathias Loesche, Adam D. Linstedt

The mammalian GRASP proteins are Golgilocalized homotypic membrane tethers that organize Golgi stacks into a long, contiguous ribbon-like structure. It is unknown how GRASPs undergo trans pairing given that cis interactions between the proteins in the

Modification of Tethered Bilayers by Phospholipid Exchange with Vesicles

February 27, 2013

Author(s)

Rima Budvytyte, Mindaugas Mickevicius, David J. Vanderah, Frank Heinrich, Gintaras Valincius

Biomimetic Supported Lipid Bilayers with High Cholesterol Content Formed by a-helical Peptide-induced Vesicle Fusion

May 24, 2012

Author(s)

Gregory J. Hardy, Rahul Nayak, S. Munir Alam, Joseph G. Shapter, Frank N. Heinrich, Stefan Zauscher

In this study, we present a technique to create a complex, high cholesterol-containing SLB using α-helical (AH) peptide-induced vesicle fusion. Vesicles consisting of POPC: POPE: POPS: SM: Chol (9.35: 19.25: 8.25: 18.15: 45.00) were used to form a SLB that

Membrane Association of the PTEN Tumor Suppressor: Molecular Details of the Protein-Membrane Complex from SPR Binding Studies and Neutron Reflection

April 10, 2012

Author(s)

Siddharth Shenoy, Prabhanshu Shekhar, Frank Heinrich, Maria-Claire Daou, Arne Gericke, Alonzo H. Ross, Mathias Loesche

The structure and function of the PTEN phosphatase is investigated by studying its membrance affinity and localization on in-plane fluid, thermally disordered synthetic membrane models. The membrane association of the protein depends strongly on membrane

Molecular Insights into a-Synuclein and Its N-terminal Peptides at the Membrane Interface

February 1, 2012

Author(s)

Candace M. Pfefferkorn, Frank Heinrich, Alexander J. Sodt, Alexander S. Malstev, Richard W. Pastor, Jennifer C. Lee

The role of phospholipids in modulating α-synuclein (α-syn) conformation is of great interest because α-syn aggregation is linked to Parkinson¿s disease. Using a sparsely tethered-bilayer composed of 1:1 molar ratio of 1-palmitoyl-2-oleoyl-sn-glycero-3

Coverage-Dependent Morphology of PEGylated Lysozyme Layers Adsorbed on Silica

January 4, 2012

Author(s)

Sheetal S. Pai, Frank Heinrich, Adam L. Canady, Todd M. Przybycien, Robert D. Tilton

Neutron reflection was used to characterize the adsorbed layer structure for lysozyme conjugated at the N-terminus with a single perdeuterated methoxy poly(ethylene glycol) chain at the silica/water interface. Adsorbed layers were produced with two

When Beauty is Only Skin Deep; Optimizing the Sensitivity of Specular Neutron Reflectivity for Probing Structure Beneath the Surface of Thin Films

November 30, 2011

Author(s)

Charles F. Majkrzak, Elisabeth Carpenter, Frank Heinrich, Norman F. Berk

Phase-Sensitive Specular Neutron Reflectometry for Imaging the Nanometer Scale Compositional Depth profile of Thin-Film Materials

November 20, 2011

Author(s)

Brian Kirby, Paul A. Kienzle, Brian B. Maranville, Norman F. Berk, J. Krycka, Frank Heinrich, Charles Majkrzak

Neutron reflectometry is a powerful method for probing the molecular scale structure of both hard and soft condensed matter films. Moreover, the phase-sensitive methods which have been developed make it possible for specular neutron reflectometry to be

Structure of Functional Staphylococcus aureus ?-Hemolysin Channels in Tethered Bilayer Lipid Membranes

February 2, 2009

Author(s)

D. McGillivray, Gintaras Valincius, Frank Heinrich, Joseph W. Robertson, David J. Vanderah, W. Febo-Ayala, I. Ignatjev, M. Losche, John J. Kasianowicz

Soluble Amyloid beta-Oligomers Affect Dielectric Membrane Properties by Bilayer Insertion and Domain Formation: Implications for Cell Toxicity

November 15, 2008

Author(s)

Gintaras Valincius, Frank Heinrich, R Budvytye, David J. Vanderah, Duncan J. McGillivray, Y Sokolov, J E. Hall, Mathias Losche

Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes

March 1, 2007

Author(s)

Duncan J. McGillivray, Gintaras Valincius, David J. Vanderah, W. Febo-Ayala, John T. Woodward IV, Frank Heinrich, John J. Kasianowicz, Mathias Losche

The Network Security Center: a System Level Approach to Computer Network Security

January 1, 1978

Author(s)

Frank N. Heinrich

This report describes a unique approach to the solution of computer network security problems, and provides guidance in the areas of network security architectural issues and implementation options. The approach is based on a network resource, called a

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