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Search Publications by: Joseph Curtis (Fed)

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Displaying 51 - 75 of 90

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties Among Polyubiquitins

March 1, 2016
Author(s)
Carlos A. Castaneda, Emma K. Dixon, Olivier Walker, Apurva Chaturvedi, Mark A. Nakasone, Joseph E. Curtis, Megan R. Reed, Susan T. Krueger, T. Ashton Cropp, David Fushman
Polyubiquitination, a critical protein post-translational modification, signals fora diverse set of cellular events via the different isopeptide linkages formed between the C0terminus of one ubiquitin (Ub) and the ε}-amine of K6, K11, K27, K29, K33, K48

Linkage-Specific Conformational Ensembles of Non-Canonical Polyubiquitin Chains

February 28, 2016
Author(s)
Carlos A. Castaneda, Apurva Chaturvedi, Christina M. Camara, Joseph E. Curtis, Susan T. Krueger, David Fushman
Polyubiquitination is a critical protein post-translational modification involved in a variety of processes in eukaryotic cells. The molecular basis for selective recognition of the polyubiquitin signals by cellular receptors is determined by the

The GenApp Framework Integrated with Airavata for Managed Compute Resource Submissions

November 16, 2015
Author(s)
Emre H. Brookes, Nadeem Anjum, Joseph E. Curtis, Suresh Marru, Raminder Singh, Marlon Pierce
A new framework (GenApp) for rapid generation of scientific applications running on a variety of systems including science gateways has recently been developed . This framework currently builds a GUI and/or web based user interface for a variety of target

Structural Features of Membrane-bound Glucocerebrosidase and a-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

January 9, 2015
Author(s)
Thai Leong Yap, Zhiping Jiang, Frank Heinrich, James M. Gruschus, Candace M. Pfefferkorn, Marilia Barros, Joseph E. Curtis, Ellen Sidransky, Jennifer C. Lee
Mutations in glucocerebrosidase (GCase), the enzyme deficient in Gaucher disease, are a common genetic risk factor for the development of Parkinson disease (PD) and related disorders, implicating the role of this lysosomal hydrolase in the disease etiology

GenApp Module Execution and Airavata Integration

November 1, 2014
Author(s)
Emre H. Brookes, Nadeem Anjum, Joseph E. Curtis, Suresh Marru, Raminder Singh, Marlon Pierce
A new framework (GenApp) for rapid generation of scientific applications running on a variety of systems including science gateways has recently been developed. This framework builds a user interface for a variety of target environments on a collection of

Structural Model of an mRNA in Complex with the Bacterial Chaperone Hfq

October 20, 2014
Author(s)
Yi Peng, Joseph E. Curtis, Xianyang Fang, Sarah A. Woodson
Small non-coding (s)RNAs and their chaperone protein Hfq regulate bacterial gene expression in response to stress and other environmental signals. Hfq binds specific RNA sequence motifs and facilitates base pairing between complementary sRNA-mRNA pairs

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

April 15, 2014
Author(s)
Eric J. Yearley, Paul D. Godfrin, Tatiana NMN Perevozchikova, Hailiang Zhang, Peter Falus, Lionel Porcar, Michihiro Nagao, Joseph E. Curtis, Pradad Gawande, Rosalynn Taing, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. Some concentrated mAb solutions are hypothesized to exhibit the formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is

Influence Of Sorbitol on Protein Crowding in Solution and Freeze-Concentrated Phases

March 31, 2014
Author(s)
Sheila Khodadadi, Nicholas James Clark, Arnold McAuley, Viviana Cristiglio, Joseph E. Curtis, Evgenyi Y. Shalaev, Susan T. Krueger
Protein stability during processing and storage is of great challenge for biotechnology and pharmaceutical industries. Polyhydroxy compounds are well-known cryo- and lyo-protectors, which minimize destabilization of proteins and biological systems during

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

October 11, 2013
Author(s)
Nicholas James Clark, Hailiang Zhang, Susan T. Krueger, Hyo Jin Lee, Randy R. Ketchem, Bruce Kerwin, Sekhar R. Kanapuram, Michael J. Treuheit, Arnold McAuley, Joseph E. Curtis
Monoclonal antibodies (mAbs) contain hinge-like regions of structural flexibility that enable the mobility of globular domains that have direct effect on biological function. A subclass of human mAbs, IgG2, has several inter-chain disulfide bonds in the
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