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Search Publications by: Joseph Curtis (Fed)

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Displaying 26 - 43 of 43

The GenApp Framework Integrated with Airavata for Managed Compute Resource Submissions

November 16, 2015
Author(s)
Emre H. Brookes, Nadeem Anjum, Joseph E. Curtis, Suresh Marru, Raminder Singh, Marlon Pierce
A new framework (GenApp) for rapid generation of scientific applications running on a variety of systems including science gateways has recently been developed . This framework currently builds a GUI and/or web based user interface for a variety of target

Structural Features of Membrane-bound Glucocerebrosidase and a-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

January 9, 2015
Author(s)
Thai Leong Yap, Zhiping Jiang, Frank Heinrich, James M. Gruschus, Candace M. Pfefferkorn, Marilia Barros, Joseph E. Curtis, Ellen Sidransky, Jennifer C. Lee
Mutations in glucocerebrosidase (GCase), the enzyme deficient in Gaucher disease, are a common genetic risk factor for the development of Parkinson disease (PD) and related disorders, implicating the role of this lysosomal hydrolase in the disease etiology

GenApp Module Execution and Airavata Integration

November 1, 2014
Author(s)
Emre H. Brookes, Nadeem Anjum, Joseph E. Curtis, Suresh Marru, Raminder Singh, Marlon Pierce
A new framework (GenApp) for rapid generation of scientific applications running on a variety of systems including science gateways has recently been developed. This framework builds a user interface for a variety of target environments on a collection of

Structural Model of an mRNA in Complex with the Bacterial Chaperone Hfq

October 20, 2014
Author(s)
Yi Peng, Joseph E. Curtis, Xianyang Fang, Sarah A. Woodson
Small non-coding (s)RNAs and their chaperone protein Hfq regulate bacterial gene expression in response to stress and other environmental signals. Hfq binds specific RNA sequence motifs and facilitates base pairing between complementary sRNA-mRNA pairs

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

April 15, 2014
Author(s)
Eric J. Yearley, Paul D. Godfrin, Tatiana NMN Perevozchikova, Hailiang Zhang, Peter Falus, Lionel Porcar, Michihiro Nagao, Joseph E. Curtis, Pradad Gawande, Rosalynn Taing, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. Some concentrated mAb solutions are hypothesized to exhibit the formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is

Influence Of Sorbitol on Protein Crowding in Solution and Freeze-Concentrated Phases

March 31, 2014
Author(s)
Sheila Khodadadi, Nicholas James Clark, Arnold McAuley, Viviana Cristiglio, Joseph E. Curtis, Evgenyi Y. Shalaev, Susan T. Krueger
Protein stability during processing and storage is of great challenge for biotechnology and pharmaceutical industries. Polyhydroxy compounds are well-known cryo- and lyo-protectors, which minimize destabilization of proteins and biological systems during

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

October 11, 2013
Author(s)
Nicholas James Clark, Hailiang Zhang, Susan T. Krueger, Hyo Jin Lee, Randy R. Ketchem, Bruce Kerwin, Sekhar R. Kanapuram, Michael J. Treuheit, Arnold McAuley, Joseph E. Curtis
Monoclonal antibodies (mAbs) contain hinge-like regions of structural flexibility that enable the mobility of globular domains that have direct effect on biological function. A subclass of human mAbs, IgG2, has several inter-chain disulfide bonds in the

Small-Angle Neutron Scattering Study of Protein Crowding in Liquid and Solid Phases: Lysozyme in Aqueous Solution, Frozen Solution, and Carbohydrate Powders

July 23, 2012
Author(s)
Joseph E. Curtis, Hirsh Nanda, Sheila Khodadadi, Marcus T. Cicerone, Hyo Jin Lee, Arnold McAuley, Susan Krueger
The structure, interactions and inter-protein configurations of the protein lysozyme were studied in a variety of phases that are biotechnologically relevant for proteins using small-angle neutron scattering (SANS) and Monte Carlo simulations. These

Role of Methyl Groups in Dynamics and Evolution of Biomolecules

June 1, 2012
Author(s)
Jonathan Nickels, Joseph E. Curtis, Hugh O'Neill, Alexei P. Sokolov
Early life was based on RNA and while RNA based catalytic molecules still function in biology to this day, studies have discovered a strong difference between dynamics of proteins and nucleic acids (DNA and RNA), especially at lower hydrations and low

Pronounced micro-segregation in a sorbitol water mixture observed through variable temperature neutron scattering

May 16, 2012
Author(s)
Shin G. Chou, Sheila Khodadadi, Joseph E. Curtis, Susan Krueger, Evgenyi Shalaev, Alan Soper, Andy Fitch, T Narayanan, Michael Szutucki, Marcus T. Cicerone
In this study, we use small and wide angle X-ray and neutron scattering measurements, to study the structure of concentrated sorbitol solutions and glasses at different temperatures. The analysis of the data suggests the water forms clusters with a

Atomistic Ensemble Modeling and Small-Angle Neutron Scattering of Intrinsically Disordered Protein Complexes: Applied to Minichromosome Maintenance Protein

December 15, 2011
Author(s)
Susan Krueger, Jae-Ho Shin, Sindhushree NMN Raghunandan, Joseph E. Curtis, Zvi Kelman
The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea and eukarya. The solution structure of the N-terminal portion of the MCM complex from the archaeon Methanothermobacter thermautotrophicus {N-mtMCM

Protein Dynamics on the Nanosecond Time Scale: Dielectric and Simulation Studies

April 22, 2011
Author(s)
Sheila Khodadadi, Joseph E. Curtis, A. P. Sokolov
We studied dynamics of hydrated Rnase A and its hydration shell by combining MD simulations and Dielectric spectroscopy technique. The results show that there are not significant numbers of water molecules at the protein surface which are able to exchange