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Search Publications by: Joseph Curtis (Fed)

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Displaying 76 - 90 of 90

Solution Conformations of Prototype Foamy Virus Integrase and Its Stable Synaptic Complex with U5 Viral DNA

November 1, 2012
Author(s)
Kushol Gupta, Joseph E. Curtis, Susan N. Krueger, Young Hwang, Peter Cherepanov, Frederic Bushman, Gregory D. Van Duyne
The recently determined crystal structures of prototype foamy virus integrase (PFV IN) in complex with viral DNA and target DNA reveal the first high-resolution insights into the nucleoprotein intermediates involved in retroviral integration. Using small

Small-Angle Neutron Scattering Study of Protein Crowding in Liquid and Solid Phases: Lysozyme in Aqueous Solution, Frozen Solution, and Carbohydrate Powders

July 23, 2012
Author(s)
Joseph E. Curtis, Hirsh Nanda, Sheila Khodadadi, Marcus T. Cicerone, Hyo Jin Lee, Arnold McAuley, Susan Krueger
The structure, interactions and inter-protein configurations of the protein lysozyme were studied in a variety of phases that are biotechnologically relevant for proteins using small-angle neutron scattering (SANS) and Monte Carlo simulations. These

Role of Methyl Groups in Dynamics and Evolution of Biomolecules

June 1, 2012
Author(s)
Jonathan Nickels, Joseph E. Curtis, Hugh O'Neill, Alexei P. Sokolov
Early life was based on RNA and while RNA based catalytic molecules still function in biology to this day, studies have discovered a strong difference between dynamics of proteins and nucleic acids (DNA and RNA), especially at lower hydrations and low

Pronounced micro-segregation in a sorbitol water mixture observed through variable temperature neutron scattering

May 16, 2012
Author(s)
Shin G. Chou, Sheila Khodadadi, Joseph E. Curtis, Susan Krueger, Evgenyi Shalaev, Alan Soper, Andy Fitch, T Narayanan, Michael Szutucki, Marcus T. Cicerone
In this study, we use small and wide angle X-ray and neutron scattering measurements, to study the structure of concentrated sorbitol solutions and glasses at different temperatures. The analysis of the data suggests the water forms clusters with a

Atomistic Ensemble Modeling and Small-Angle Neutron Scattering of Intrinsically Disordered Protein Complexes: Applied to Minichromosome Maintenance Protein

December 15, 2011
Author(s)
Susan Krueger, Jae-Ho Shin, Sindhushree NMN Raghunandan, Joseph E. Curtis, Zvi Kelman
The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea and eukarya. The solution structure of the N-terminal portion of the MCM complex from the archaeon Methanothermobacter thermautotrophicus {N-mtMCM

Protein Dynamics on the Nanosecond Time Scale: Dielectric and Simulation Studies

April 22, 2011
Author(s)
Sheila Khodadadi, Joseph E. Curtis, A. P. Sokolov
We studied dynamics of hydrated Rnase A and its hydration shell by combining MD simulations and Dielectric spectroscopy technique. The results show that there are not significant numbers of water molecules at the protein surface which are able to exchange
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