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Search Publications by: Karen W. Phinney (Fed)

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Displaying 51 - 75 of 94

A Proteomics Performance Standard to Support Measurement Quality in Proteomics

April 21, 2012
Author(s)
Ashley B. Green, David M. Bunk, Paul A. Rudnick, Karen W. Phinney, Lisa E. Kilpatrick
The emergence of mass spectrometry-based proteomic platforms as a prominent technology utilized in biochemical and biomedical research has increased the need for high-quality MS measurements. To address this need, NIST Reference Material (RM) 8323 Yeast

Development and Certification of a Standard Reference Material for Vitamin D Metabolites in Human Serum

December 5, 2011
Author(s)
Karen W. Phinney, Mary Bedner, Susan Tai, Veronica V. Vamathevan, Lane C. Sander, Katherine E. Sharpless, Stephen A. Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health’s Office of Dietary Supplements (NIH-ODS) has developed a Standard Reference Material (SRM) for the determination of 25-hydroxyvitamin D [25

Isotope Dilution Liquid Chromatography - Mass Spectrometry Methods for Fat- and Water-Soluble Vitamins in Nutritional Formulations

November 24, 2011
Author(s)
Karen W. Phinney, Catherine A. Rimmer, Jeanice M. Brown Thomas, Lane C. Sander, Katherine E. Sharpless, Stephen A. Wise
Vitamins are essential to human health, and dietary supplements containing vitamins are widely used by individuals hoping to ensure they have adequate intake of these important nutrients. Measurement of vitamins in nutritional formulations is necessary to

Development of a Candidate Reference Measurement Procedure for the Determination of Phenytoin, Phenobarbital, Lamotrigine, and Topiramate in Human Serum Using Isotope-Dilution Liquid Chromotography/Tandem Mass Spectrometry

August 28, 2011
Author(s)
Susan Tai, Karen W. Phinney, Chia-Yi Yeh
Phenytoin (PHT), phenobarbital (PHB), lamotrigine (LTG), and topiramate (TPM) are some of the most widely used antiepileptic drugs (AEDs). Monitoring of their concentrations in serum is important for the treatment of epilepsy. A candidate reference

Mass Spectrometry Characterization for Chemoenzymatic Glycoprotein Synthesis

July 1, 2011
Author(s)
John E. Schiel, Mark S. Lowenthal, Karen W. Phinney
Glycoproteins exist as heterogeneous mixtures of glycoforms due to glycosylation at multiple sites with various glycans. The glycosylation pattern has significant implications for clinical diagnostics and biopharmaceutical development because it affects

Certification of Vitamins and Carotenoids in SRM 3280 Multivitamin/Multielement Tablets

April 24, 2011
Author(s)
Lane C. Sander, Katherine E. Sharpless, Stephen A. Wise, Bryant C. Nelson, Karen W. Phinney, Barbara J. Porter, Catherine A. Rimmer, Jeanice M. Brown Thomas, Laura J. Wood, James H. Yen, David L. Duewer, R. Atkinson, R. Chen, R. Goldschmidt, W.R. Wolf, I-P Ho, M. Betz
A new multivitamin/multielement dietary supplement Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) with certified and reference concentration values for 13 vitamins, 24 elements, and two

Comparison of Orthogonal Mass Spectrometry Platforms for the Determination of Amino Acid Concentrations in Human Plasma Certifying NIST Standard Reference Material 1950

August 16, 2010
Author(s)
Mark S. Lowenthal, Karen W. Phinney, Elizabeth A. McGaw
Absolute concentrations of amino acids in a human plasma pool were determined independently using four quantification methods. Orthogonal separation schemes (LC, GC, or GCxGC) and detection systems (triple quadrupole or time-of-flight mass spectrometers)

Preparation and Characterization of Standard Reference Material 1849 Infant/Adult Nutritional Formula

July 1, 2010
Author(s)
Katherine E. Sharpless, Richard M. Lindstrom, Bryant C. Nelson, Karen W. Phinney, Catherine A. Rimmer, Lane C. Sander, Michele M. Schantz, Rabia Oflaz, Jeanice M. Brown Thomas, Gregory C. Turk, Stephen A. Wise, Laura J. Wood, James H. Yen
Standard Reference Material (SRM) 1849 Infant/Adult Nutritional Formula has been issued by the National Institute of Standards and Technology (NIST) as a replacement for SRM 1846 Infant Formula, which was issued in 1996. Extraction characteristics of SRM

Modifications to the NIST Reference Measurement Procedure (RMP) for the Determination of Serum Glucose by Isotope Dilution Gas Chromatography/ Mass Spectrometry

April 27, 2010
Author(s)
Jocelyn L. Prendergast, Lorna T. Sniegoski, Michael J. Welch, Karen W. Phinney
NIST has been providing a Standard Reference Material (SRM) for glucose in human serum for many years to support accuracy in health care measurements. The definitive method (DM), now known as the reference measurement procedure (RMP), for the analysis of

CCQM–K62: Nutrients in Infant/Adult Formula – Vitamins

April 24, 2010
Author(s)
Katherine E. Sharpless, Catherine A. Rimmer, Karen W. Phinney, Bryant C. Nelson, David L. Duewer, Stephen A. Wise
Key Comparison CCQM-K62 was designed to enable demonstration of the equivalence in capabilities for measurement of vitamins in a food matrix. A milk-based fortified human infant/adult formula was selected as the matrix based upon material availability and

CCQM–K62: Nutrients in Infant/Adult Formula – Vitamins: Final Report

April 24, 2010
Author(s)
Katherine E. Sharpless, Catherine A. Rimmer, Karen W. Phinney, Bryant C. Nelson, David L. Duewer, Stephen A. Wise
Key Comparison CCQM-K62 was designed to enable demonstration of the equivalence in capabilities for measurement of vitamins in a food matrix. A milk-based fortified human infant/adult formula was selected as the matrix based upon material availability and

Certification of Drugs of Abuse in a Human Serum Standard Reference Material: SRM 1959

March 24, 2010
Author(s)
Susan S. Tai, Jocelyn L. Prendergast, Lorna T. Sniegoski, Michael J. Welch, Karen W. Phinney, Nien F. Zhang
A new Standard Reference Material (SRM) for drugs of abuse in human serum (SRM 1959) has been developed. SRM 1959 is a frozen human serum material fortified with seven drugs of abuse, benzoylecgonine (BZE), methadone (METH), methamphetamine (MAMP)

Development of a Candidate Reference Measurement Procedure for the Determination of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in Human Serum Using Isotope-Dilution Liquid Chromatography/Tandem Mass Spectrometry

February 5, 2010
Author(s)
Susan S. Tai, Mary Bedner, Karen W. Phinney
Vitamin D exists in two major forms, vitamin D3 and vitamin D2. Vitamin D helps the body absorb calcium and promote optimal growth. Both forms of vitamin D are metabolized to 25-hydroxyvitamin D in the body, and the levels of 25-hydroxyvitamin D3 (25-(OH

Dietary Supplement Standard Reference Materials

October 1, 2009
Author(s)
Lane C. Sander, Karen W. Phinney, Michele M. Schantz, Katherine E. Sharpless, Stephen A. Wise
In 1994, the U.S. Congress enacted the Dietary Supplement Health and Education Act to "protect the right of access of consumers to safe dietary supplements". In response to this legislation, the National Institute of Standards and Technology (NIST), the

Preparation and Characterization of a Suite of Ephedra-Containing Standard Reference Materials

November 1, 2006
Author(s)
Katherine E. Sharpless, David L. Anderson, Therese A. Butler, J. M. Betz, Douglas A. Howell, S. G. Capar, J. Cheng, C. Fraser, G. Gardner, T. Ihara, J. W. Lam, Stephen E. Long, Elizabeth A. Mackey, M. McCooeye, Karen E. Murphy, W. R. Mindak, S. Mitvalsky, Karen W. Phinney, Barbara J. Porter, A. NguyenPho, Lane C. Sander, M. C. Roman, Mary B. Satterfield, Jeanice M. Brown Thomas, C. Scriver, R. E. Sturgeon, Robert D. Vocke Jr., Stephen A. Wise, Laura J. Wood, James H. Yen, L. Yang, G. C. Ziobro

Preparation and Characterization of a Suite of Ephedra-Containing Standard Reference Materials

June 1, 2006
Author(s)
Katherine E. Sharpless, D L. Anderson, J. M. Betz, Therese A. Butler, S. G. Capar, J. Cheng, C. Fraser, M. L. Gay, G. Gardner, D W. Howell, T. Ihara, J. W. Lam, Stephen E. Long, M. McCooeye, Elizabeth A. Mackey, W. R. Mindak, S. Mitvalsky, Karen E. Murphy, Karen W. Phinney, A. NguyenPho, Barbara J. Porter, M. C. Roman, Lane C. Sander, Mary B. Satterfield, C. Scriver, R. E. Sturgeon, Jeanice M. Brown Thomas, Robert D. Vocke Jr., Stephen A. Wise, Laura J. Wood, L. Yang, James H. Yen, G. C. Ziobro