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Search Publications by: Susan Krueger (Assoc)

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Displaying 26 - 50 of 58

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

December 5, 2017
Author(s)
Mark A. Nakasone, Timothy A. Lewis, Olivier Walker, Anita Thakur, Wissam Mansour, Carlos A. Castaneda, Jennifer L. Goeckeler-Fried, Frank Parlati, Tsui-Fen Chou, Ortal Hayat, Daoning Zhang, Christina M. Camara, Steven M. Bonn, Urszula K. Nowicka, Susan T. Krueger, Michael H. Glickman, Jeffrey L. Brodsky, Raymond J. Deshaies, David Fushman
The success of proteasome inhibitors has led to intense efforts to discover points of therapeutic intervention for nearly every component of the ubiquitin-proteasome system. The discovery of ubistatins, small molecules that inhibit proteasomal degradation

Trends in Thermoresponsive Behavior of Lipophilic Polymers

December 1, 2016
Author(s)
Priyanka Bhattacharya, Uma Shantini Ramasamy, Susan T. Krueger, Joshua W. Robinson, Barbara J. Tarasevich, Ashlie Martini, Lelia Cosimbescu
In an effort to look for correlations between viscosity index trends of polymers in oils and size changes of polymers in solution with temperature, the determination of the size of thermo-responsive polymers of various architectures (linear, comb, star

Role of Molecular Flexibility and Colloidal Descriptions of Proteins in Crowded Environments from Small-Angle Scattering

November 10, 2016
Author(s)
Maria Monica Castellanos Mantilla, Nicholas J. Clark, Max C. Watson, Susan Krueger, Arnold McAuley, Joseph Curtis
Small-angle scattering is a powerful technique to study molecular conformation and interactions in a variety of systems. Recent work has questioned the validity of analyzing small-angle scattering data of protein solutions with models from the colloidal

Atomistic Modelling of Scattering Data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS) 1

October 17, 2016
Author(s)
Stephen J. Perkins, David W. Wright, Hailiang Zhang, Emre H. Brookes, Jianhan Chen, Thomas C. Irving, Susan T. Krueger, David J. Barlow, Karen J. Edler, David J. Scott, Nicholas J. Terrill, Stephen M. King, Paul Butler, Joseph E. Curtis
In solution scattering, the major investment worldwide in multiuser X-ray synchrotrons and neutron sources have resulted in huge advances in the throughput and accuracy of the experimental measurements. Whilst closed-source non-atomistic analytical

Deuterium Labeling Together with Contrast Variation Small-Angle Neutron Scattering Suggests How Skp Captures and Releases Unfolded Outer Membrane Proteins

August 4, 2016
Author(s)
Nathan R. Zaccai, Clifford W. Sandlin, James T. Hoopes, Joseph E. Curtis, Patrick J. Fleming, Karen G. Fleming, Susan T. Krueger
In gram¿negative bacteria, the chaperone protein Skp forms specific and stable complexes with membrane proteins as these are transported across the periplasm to the outer membrane. The jellyfish¿like architecture of Skp is similar to the eukaryotic and

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties Among Polyubiquitins

March 1, 2016
Author(s)
Carlos A. Castaneda, Emma K. Dixon, Olivier Walker, Apurva Chaturvedi, Mark A. Nakasone, Joseph E. Curtis, Megan R. Reed, Susan T. Krueger, T. Ashton Cropp, David Fushman
Polyubiquitination, a critical protein post-translational modification, signals fora diverse set of cellular events via the different isopeptide linkages formed between the C0terminus of one ubiquitin (Ub) and the ε}-amine of K6, K11, K27, K29, K33, K48

Linkage-Specific Conformational Ensembles of Non-Canonical Polyubiquitin Chains

February 28, 2016
Author(s)
Carlos A. Castaneda, Apurva Chaturvedi, Christina M. Camara, Joseph E. Curtis, Susan T. Krueger, David Fushman
Polyubiquitination is a critical protein post-translational modification involved in a variety of processes in eukaryotic cells. The molecular basis for selective recognition of the polyubiquitin signals by cellular receptors is determined by the

The Leucine-Rich Amelogenin Peptide (LRAP) is a Partially Structured Monomer in Solution

October 25, 2014
Author(s)
Barbara J. Tarasevich, John S. Philo, Nasib Karl Mulof, Susan T. Krueger, Garry W. Buchko, Genyao Lin, Wendy J. Shaw
Amelogenin proteins are critical to the formation of enamel in teeth and may have roles in promoting nucleation, controlling growth, and regulating microstructures of the intricately woven hydroxyapatite (HAP). Leucine-rich amelogenin peptide (LRAP) is a

Phase-Sensitive Small-Angle Neutron Scattering

April 1, 2014
Author(s)
Charles F. Majkrzak, Kathryn L. Krycka, Susan Krueger, Norman F. Berk, Paul A. Kienzle, Brian B. Maranville
A method is described for determining the neutron scattering length density distribution of a molecular scale object directly from phase-sensitive small angle neutron scattering (SANS). The structure factor amplitude is obtained through the use of a

Influence Of Sorbitol on Protein Crowding in Solution and Freeze-Concentrated Phases

March 31, 2014
Author(s)
Sheila Khodadadi, Nicholas James Clark, Arnold McAuley, Viviana Cristiglio, Joseph E. Curtis, Evgenyi Y. Shalaev, Susan T. Krueger
Protein stability during processing and storage is of great challenge for biotechnology and pharmaceutical industries. Polyhydroxy compounds are well-known cryo- and lyo-protectors, which minimize destabilization of proteins and biological systems during

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

October 11, 2013
Author(s)
Nicholas James Clark, Hailiang Zhang, Susan T. Krueger, Hyo Jin Lee, Randy R. Ketchem, Bruce Kerwin, Sekhar R. Kanapuram, Michael J. Treuheit, Arnold McAuley, Joseph E. Curtis
Monoclonal antibodies (mAbs) contain hinge-like regions of structural flexibility that enable the mobility of globular domains that have direct effect on biological function. A subclass of human mAbs, IgG2, has several inter-chain disulfide bonds in the

A Generalized Strategy for Immobilizing Uniformly Oriented Membrane Proteins at Solid Interfaces

February 13, 2013
Author(s)
Amit NMN Vaish, Vitalii I. Silin, Marlon L. Walker, Kristen L. Steffens, Susan Krueger, Alexei A. Yeliseev, Klaus Gawrisch, David J. Vanderah
We present here a generalized strategy for immobilizing uniformly oriented membrane proteins onto a functionalized surface. Using water soluble nitrilotriacetic acid (NTA)-terminated oligo(ethylene glycol) thiols, a histidine-tagged G protein-coupled

Solution Conformations of Prototype Foamy Virus Integrase and Its Stable Synaptic Complex with U5 Viral DNA

November 1, 2012
Author(s)
Kushol Gupta, Joseph E. Curtis, Susan N. Krueger, Young Hwang, Peter Cherepanov, Frederic Bushman, Gregory D. Van Duyne
The recently determined crystal structures of prototype foamy virus integrase (PFV IN) in complex with viral DNA and target DNA reveal the first high-resolution insights into the nucleoprotein intermediates involved in retroviral integration. Using small

Small-Angle Neutron Scattering Study of Protein Crowding in Liquid and Solid Phases: Lysozyme in Aqueous Solution, Frozen Solution, and Carbohydrate Powders

July 23, 2012
Author(s)
Joseph E. Curtis, Hirsh Nanda, Sheila Khodadadi, Marcus T. Cicerone, Hyo Jin Lee, Arnold McAuley, Susan Krueger
The structure, interactions and inter-protein configurations of the protein lysozyme were studied in a variety of phases that are biotechnologically relevant for proteins using small-angle neutron scattering (SANS) and Monte Carlo simulations. These

Pronounced micro-segregation in a sorbitol water mixture observed through variable temperature neutron scattering

May 16, 2012
Author(s)
Shin G. Chou, Sheila Khodadadi, Joseph E. Curtis, Susan Krueger, Evgenyi Shalaev, Alan Soper, Andy Fitch, T Narayanan, Michael Szutucki, Marcus T. Cicerone
In this study, we use small and wide angle X-ray and neutron scattering measurements, to study the structure of concentrated sorbitol solutions and glasses at different temperatures. The analysis of the data suggests the water forms clusters with a

Atomistic Ensemble Modeling and Small-Angle Neutron Scattering of Intrinsically Disordered Protein Complexes: Applied to Minichromosome Maintenance Protein

December 15, 2011
Author(s)
Susan Krueger, Jae-Ho Shin, Sindhushree NMN Raghunandan, Joseph E. Curtis, Zvi Kelman
The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea and eukarya. The solution structure of the N-terminal portion of the MCM complex from the archaeon Methanothermobacter thermautotrophicus {N-mtMCM

Biomimetic Membranes on Metal Supports

May 1, 2003
Author(s)
John T. Elliott, Curtis W. Meuse, Vitalii I. Silin, Susan T. Krueger, John T. Woodward IV, T Petralli-Mallow, Anne L. Plant
Biological membranes are complex and dynamic structures. The biological functions associated with membranes involve a number of different molecular species, and theories of how the molecular species are organized are still evolving. The fluid mosaic model