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Search Publications by: Anthony J. Kearsley (Fed)

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Displaying 26 - 50 of 90

Smoothing Techniques in Dynamic Building System Simulation

August 27, 2021
Author(s)
Zhelun Chen, Jin Wen, Anthony Kearsley, Amanda Pertzborn
Efficiently, robustly, and accurately solving systems of nonlinear differential algebraic equations (DAE) for dynamic building system simulation is becoming more important due to the increasing demand to simulate large-scale problems including the

CD19 Expression Analysis Using Two Flow cytometric Quantitative Schemes: An approach for Identifying Robust B-cell Reference Control Materials

March 19, 2021
Author(s)
Hao-Wei Wang, Paul Patrone, Anthony Kearsley, Jessica Watson, Liang Lim, Jothir Pichaandi, Olga Ornatsky, Daniel Majonis, Rukmini Bhardwaj, Howard Mostowski, Steven Bauer, Heba Degheidy, Lili Wang
Cell-based therapies have emerged as a novel approach to treat cancer and other conditions. Quantitative flow cytometry plays an increasingly important role in predicting therapy outcome in a wide range of hematologic malignancies. Several studies

Towards Quantitative and Standardized Serological and Neutralization Assays for COVID-19

March 8, 2021
Author(s)
Linhua Tian, Elzafir B. Elsheikh, Paul Patrone, Anthony Kearsley, adolfas Gaigalas, Sarah L. Inwood, Sheng Lin-Gibson, Dominic Esposito, Lili Wang
Quantitative and robust serology assays are critical measurements underpinning global COVID-19 response to diagnostic, surveillance, and vaccine development. Here, we report a proof-of-concept approach for the development of quantitative, multiplexed flow

Failure mechanisms in DNA self-assembly: Barriers to single fold yield

February 23, 2021
Author(s)
Jacob Majikes, Paul Patrone, Anthony J. Kearsley, Michael P. Zwolak, James Liddle
Understanding the folding process of DNA origami is a critical steppingstone to the broader implementation of nucleic acid nanofabrication technology but is notably non-trivial. Origami are formed by several hundred cooperative hybridization events – folds

DYNAMIC MEASUREMENT OF NANOLITER PER MINUTE FLOW BY SCALED DOSAGE OF FLUORESCENT SOLUTIONS

October 3, 2020
Author(s)
Gregory A. Cooksey, Paul Patrone, James R. Hands, Stephen E. Meek, Anthony J. Kearsley
This work describes a new method for continuous measurement of flow in a microchannel from 1 nL/min to 1000 nL/min using an optofluidic device with waveguides that deliver and collect light from small regions of a microfluidic channel. By relating the

Diffusion-limited reactions in nanoscale electronics

September 22, 2020
Author(s)
Ryan Evans, Arvind Balijepalli, Anthony J. Kearsley
To quantify interactions between drug molecules and target receptors, a novel nanoscale electronics instrument is under development. The instrument consists of two regions: a biological region, and an electronics region. The biological region consists of a

Measuring Microfluidic Flow Rates: Monotonicity, Convexity and Uncertainty

August 20, 2020
Author(s)
Paul Patrone, Qing Hai Li, Gregory A. Cooksey, Anthony J. Kearsley
A class of non-linear integro-differential equations characterizing microfluidic measurements is considered. Under reasonable conditions, these non-linear integro-differential equations admit solutions that are convex functions of an interesting flow-rate

Revealing thermodynamics of DNA origami folding via affine transformations

June 4, 2020
Author(s)
Jacob M. Majikes, Paul N. Patrone, Daniel R. Schiffels, Michael P. Zwolak, Anthony J. Kearsley, Samuel P. Forry, James A. Liddle
Structural DNA nanotechnology, as exemplified by DNA origami, has enabled the design and construction of molecularly precise objects for a myriad of applications. However, limitations in imaging, and other characterization approaches, make a quantitative

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

January 1, 2019
Author(s)
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony J. Kearsley, Yves Aubin, Gregory Pierens, Xinying Jia, David Keizer, Jonas Stahle, Goran Widmalm, Chad Lawrence, Patrick Reardon, John Cort, Koichi Kato, Stuart Parnham, Andreas Blomgren, Torgny Rundlof, Kang Chen, David Keire, Thea Suter-Stahel, Gerhard Wider, Donna Baldisseri, Julie Wu, Mats Wikstrom, Medhi Mobli
Of the top ten drugs on the global market in 2016, seven of them are biologics with a combined market value of over US$60 billion. Moreover, around 2,800 biopharmaceuticals, many of them monoclonal antibodies (mAbs), are in some stage of clinical

Combining fragment ion and neutral loss matching during mass spectral library searching: A new general-purpose algorithm applicable to illicit drug identification

November 20, 2017
Author(s)
Arun S. Moorthy, William E. Wallace, Anthony J. Kearsley, Dmitrii V. Tchekhovskoi, Stephen E. Stein
A mass spectral library search algorithm that identifies compounds that differ from library compounds by a single ‘inert’ structural component is described. This algorithm, the Hybrid Similarity Search, generates a similarity score based on matching both

Scaling Methods for Dynamic Building System Simulation in an HVACSIM+ Environment

August 9, 2017
Author(s)
Zhelun Chen, Jin Wen, Anthony Kearsley, Amanda Pertzborn
A robust and efficient nonlinear algebraic and differential equations solver is increasingly essential as the scale of dynamic building system simulation grows larger and the models employed become more complex. There are many factors affecting the

Phase Equilibria of the High Tc Superconductors in the (Bi, Pb) -SR-Ca-Cu-O System

February 19, 2017
Author(s)
Winnie Wong-Ng, Lawrence P. Cook, W Greenwood, Anthony J. Kearsley
Applications of (Bi,Pb)-Sr-Ca-Cu-O phase equilibria include material synthesis, melt processing and single crystal growth. Both liquidus and subsolidus data are of central importance. For the determination of liquidus data, we have used a wicking technique
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