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Search Publications by: Anthony J. Kearsley (Fed)

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Displaying 51 - 75 of 151

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

January 1, 2019
Author(s)
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony J. Kearsley, Yves Aubin, Gregory Pierens, Xinying Jia, David Keizer, Jonas Stahle, Goran Widmalm, Chad Lawrence, Patrick Reardon, John Cort, Koichi Kato, Stuart Parnham, Andreas Blomgren, Torgny Rundlof, Kang Chen, David Keire, Thea Suter-Stahel, Gerhard Wider, Donna Baldisseri, Julie Wu, Mats Wikstrom, Medhi Mobli
Of the top ten drugs on the global market in 2016, seven of them are biologics with a combined market value of over US$60 billion. Moreover, around 2,800 biopharmaceuticals, many of them monoclonal antibodies (mAbs), are in some stage of clinical

Combining fragment ion and neutral loss matching during mass spectral library searching: A new general-purpose algorithm applicable to illicit drug identification

November 20, 2017
Author(s)
Arun S. Moorthy, William E. Wallace, Anthony J. Kearsley, Dmitrii V. Tchekhovskoi, Stephen E. Stein
A mass spectral library search algorithm that identifies compounds that differ from library compounds by a single ‘inert’ structural component is described. This algorithm, the Hybrid Similarity Search, generates a similarity score based on matching both

Scaling Methods for Dynamic Building System Simulation in an HVACSIM+ Environment

August 9, 2017
Author(s)
Zhelun Chen, Jin Wen, Anthony J. Kearsley, Amanda Pertzborn
A robust and efficient nonlinear algebraic and differential equations solver is increasingly essential as the scale of dynamic building system simulation grows larger and the models employed become more complex. There are many factors affecting the

Phase Equilibria of the High Tc Superconductors in the (Bi, Pb) -SR-Ca-Cu-O System

February 19, 2017
Author(s)
Winnie Wong-Ng, Lawrence P. Cook, W Greenwood, Anthony J. Kearsley
Applications of (Bi,Pb)-Sr-Ca-Cu-O phase equilibria include material synthesis, melt processing and single crystal growth. Both liquidus and subsolidus data are of central importance. For the determination of liquidus data, we have used a wicking technique

Efficient and Robust Optimization for building energy simulation

June 15, 2016
Author(s)
Shokouh Pourarian, Jin Wen, Anthony J. Kearsley, Amanda Pertzborn
Efficiently, robustly and accurately solving large sets of structured, non-linear algebraic and differential equations is one of the most computationally expensive steps in the dynamic simulation of building energy systems. Here, the efficiency, robustness