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Displaying 1 - 25 of 2053

Molecular Oxygen (O2) Artifacts in Tandem Mass Spectra

November 20, 2024
Author(s)
Yuxue Liang, Pedatsur Neta, Xiaoyu (Sara) Yang, Hugo Garraffo, Tallat Bukhari, Yi Liu, Stephen Stein
The NIST 2023 tandem mass spectral library contains 1,832,086 spectra of positive ions and 541,978 of negative ions from 51,501 compounds. Peak annotation plays an important role in spectrum evaluation. While most fragment ions are formed by neutral losses

Per- and Polyfluoroalkyl Substances - Non-Targeted Analysis Interlaboratory Study Final Report

October 15, 2024
Author(s)
Benjamin Place, Jessica Reiner, Jared Ragland, Alix Rodowa, Carolyn Burdette, Amy Cuthbertson, Catherine Rimmer, John Kucklick, Nathan Mahynski
Non-targeted analysis (NTA) is a technique for the identification of unknown chemicals in complex materials, such as novel per- and polyfluoroalkyl substances (PFAS) in environmental materials and commercial formulations. The PFAS NTA Interlaboratory Study

Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

October 3, 2024
Author(s)
Tracey Schock, Christina Jones, Federico Torta, Nils Hoffmann, Bo Burla, Irina Alecu, Makoto Arita, Takeshi Bamba, Steffany A.L. Bennett, Justine BERTRAND-MICHEL, Britta Brugger, Monica Molina, Maria Dolores Camacho Munoz, Antonio Checa, Michael Chen, Michelle Cinel, Benoit COLSCH, Cristina Coman, Bebiana Da Costa Sousa, Alex Dickens, Maria Maria, Finnur Freyr Eiriksson, Hector Gallart-Ayala, Mohan Ghorasaini, Martin Giera, Xue Guan, Mark Haid, Thomas Hankemeier, Amy Harms, Marcus Horing, Michal Holcapek, Thorsten Hornemann, Chunxiu Hu, Andreas Hulsmeier, Julijana Ivanisevic, Harald Kofeler, Sin Man Lam, Jong Cheol Lee, Gerhard Liebisch, Andrea F Lopez-Clavijo, Malena Manzi, Peter Meikle, Maria Monge, Sneha Muralidharan, Anna Nicolaou, Valerie O'Donnell, Matej Oresic, Arvind Ramanathan, Daisuke Saigusa, Heidi Schwartz-Zimmermann, Guanghou Shui, Masatomo Takahashi, Margret Thorsteinsdottir, Anthony Tournadre, Hiroshi Tsugawa, Victoria Tyrrell, Grace van der Gugten, Michael Wakelam, Craig Wheelock, Denise Wolrab, Guowang Xu, John Bowden, Kim Ekroos, Robert Ahrends, Markus Wenk
In this community effort, we compared measurements between 34 laboratories from 19 countries, utilizing mixtures of authentic synthetic standards, to quantify by mass spectrometry four ceramide species in the NIST human blood plasma Standard Reference

Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison

October 1, 2024
Author(s)
Clay Davis, Anneli Kruve-Viil, Louise Malm, Jaanus Liigand, Reza Aalizadeh, Nikiforos Alygizakis, Emil Egede Frokjaer, Mulatu Yohannes Nanusha, Martin Hansen, Merle Plassmann, Stefan Bieber, Thomas Letzel, Lydia Balest, Pier Paolo Abis, Michele Mazzetti, Barbara Kasprzyk-Hordern, Nicola Ceolotto, Sangeeta Kumari, Stephan Hann, Sven Kochmann, Teresa Steininger-Mairinger, Coralie Soulier, Giuseppe Mascolo, Sapia Murgolo, Manuel Garcia-Vara, Miren Lopez de Alda, Juliane Hollender, Katarzyna Arturi, Gianluca Coppola, Massimo Peruzzo, Hanna Joerss, Carla van der Neut-Marchand, Eelco N. Pieke, Ruben Gil-Solsona, Viktoria Licul-Kucera, Claudio Roscioli, Sara Valsecchi, Austeja Luckute, Jan H. Christensen, Selina Tisler, Dennis Vughs, Nienke Meekel, Begona Talavera Andujar, Dagny Aurich Dagny Aurich, Emma L. Schymanski, Gianfranco Frigerio, Andre Macherius, Uwe Kunkel, Tobias Bader, Pawel Rostkowski, Hans Gundersen, Belinda Valdecanas, Bastian Schulze, Sarit Kaserzon, Martijn Pijnappels, Mar Esperanza, Aurelie Fildier, Emmanuelle Vulliet, Laure Wiest, Adrian Covaci, Alicia Macan Schonleben, Lidia Belova, Alberto Celma, Lubertus Bijlsma, Emilie Caupos, Emmanuelle Mebold, Julien Le Roux, Eugenie Troia, Eva de Rijke, Rick Helmus, Gaela Leroy, Niels Haelewyck, David Chrastina, Milan Verwoert, Nikolaos S. Thomaidis
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants. Major differences in the ionization efficiency of compounds in

Feasibility of Metrological Traceability Implementation Using the Joint Committee on Traceability in Laboratory Medicine Database Entries Including the Fulfillment of "Fit-for-Purpose" Maximum Allowable Measurement Uncertainty

September 24, 2024
Author(s)
MAURO PANTEGHINI, Johanna Camara, VINCENT DELATOUR, Katleen Van Uytfanghe, Hubert Vesper, Tianjiao Zhang
Background: In previous publications, the Task Force on Reference Measurement System Implementation proposed a procedural approach combining a critical review of entries available in the Joint Committee on Traceability in Laboratory Medicine (JCTLM)

Value assignment and uncertainty evaluation for certified reference gas mixtures

September 9, 2024
Author(s)
Christina Cecelski, Jennifer Carney, Antonio Possolo
The procedures used to assign values to certified reference gas mixtures and to evaluate their associated uncertainties, which are described in ISO 6143, and that were variously improved by Guenther and Possolo (Anal Bioanal Chem 399:489–500, 2011. 10.1007

Random and systematic uncertainty in ship-based seawater carbonate chemistry observations

September 8, 2024
Author(s)
Brendan Carter, Jonathan Sharp, Maribel I. Garcia-Ibanez, Ryan J. Woosley, Michael Fong, Marta Alvarez, Leticia Barbero, Simon Clegg, Regina Easley, Andrea Fassbender, Xinyu Li, Katelyn Schockman, Zhaohui Aleck Wang, Andrew Dickson
Seawater carbonate chemistry observations are increasingly necessary to study a broad array of oceanographic challenges such as ocean acidification, carbon inventory tracking, and assessment of marine carbon dioxide removal strategies. As a result, efforts

Variation of Site-Specific Glycosylation Profiles of Recombinant Influenza Glycoproteins

August 9, 2024
Author(s)
Zachary Goecker, Meghan Burke Harris, Concepcion Remoroza, Yi Liu, Yuri Mirokhin, Sergey Sheetlin, Dmitrii V. Tchekhovskoi, Xiaoyu (Sara) Yang, Stephen E. Stein
This work presents a detailed determination of site-specific N-glycan distributions of the recombinant influenza glycoproteins hemagglutinin (HA) and neuraminidase. Variation in glycosylation among recombinant glycoproteins is not predictable and can

Orthogonal Determination of Competing Surfactant Adsorption onto Single-Wall Carbon Nanotubes During Aqueous Two-Polymer Phase Extraction via Fluorescence Spectroscopy and Analytical Ultracentrifugation

July 31, 2024
Author(s)
Christopher Sims, Jeffrey Fagan
A combination of analytical ultracentrifugation (AUC) and fluorescence spectroscopy are utilized to orthogonally probe compositions of adsorbed surfactant layers on the surface of (7,5) species single-wall carbon nanotubes (SWCNTs) under conditions known

Bilirubin measurements in neonates: uniform neonatal treatment can only be achieved by improved standardization

July 26, 2024
Author(s)
Christian Hulzebos, Johanna Camara, Miranda van Berkel, VINCENT DELATOUR, Stanley Lo, Agnes Mailloux, Marcel Schmidt, Mercy Thomas, Lindsey Mackay, Ronda Greaves
Measurement of total serum bilirubin (TSB) concentration is the gold standard approach for diagnosing neonatal unconjugated hyperbilirubinemia. It is of utmost importance that the measured TSB concentration is sufficiently accurate to prevent

Metabolomics 2023 Workshop Report: Moving Toward Consensus on Best QA/QC Practices in LC-MS-Based Untargeted Metabolomics

July 9, 2024
Author(s)
Tracey Schock, Jonathan Mosley, Warwick Dunn, Julia Kuligowski, Matthew Lewis, Maria Monge, Candice Ulmer Holland, Dajana Vuckovic, Krista Zanetti
Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a workshop focusing on key quality assurance and quality control (QA/QC) topic categories for LC-MS-based untargeted

Cannabis Laboratory Quality Assurance Program: Exercise 2 Cannabinoid Final Report

June 25, 2024
Author(s)
Andrea Yarberry, Melissa M. Phillips, Walter Brent Wilson
NIST launched a Cannabis Laboratory Quality Assurance Program (CannaQAP) in 2020 to assist laboratories in demonstrating and improving cannabis (hemp and marijuana) measurement comparability and competence. CannaQAP provides tools that allow analysts and

Characterization of Reference Material 8210: Hemp Plant

June 20, 2024
Author(s)
Colleen E. Bryan Sallee, Walter Brent Wilson, Charles Barber, Monique Johnson, Jenna Klingsick, Jerome Mulloor, Blaza Toman, Elena Wood, Laura Wood, Andrea Yarberry
The National Institute of Standards and Technology (NIST) Reference Material (RM) 8210 Hemp Plant delivers non certified values for cannabinoids and toxic elements in a dried ground hemp plant material to help cannabis and forensic laboratories for use as

Mixture effects of PFAS on embryonic and larval sheepshead minnows (Cyprinodon variegatus)

May 22, 2024
Author(s)
Philip Tanabe, Peter Key, Katy Chung, Emily Pisarski, Jessica Reiner, Alix Rodowa, Jason Magnuson, Marie DeLorenzo
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and persistent environmental contaminants originating from many everyday products. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are two PFAS that are commonly found at high

Observation of a promethium complex in solution

May 22, 2024
Author(s)
Bruce D. Ravel, Darren Driscoll, Frankie White, SUBHAMAY PRAMANIK, Jeffrey Einkauf, Dmytro Bykov, Santanu Roy, Richard Mayes, Laetitia Delmau, Samantha Schrell, Thomas Dyke, April Miller, Matt Silveira, Silveira2 van Cleve, Roy Copping, Sandra Davern, Santa Jansone-Popova, Ilja Popovs, Alexander Ivanov
Lanthanide rare earth metals are ubiquitous in modern technologies, but we know little about chemistry of the 61st element, promethium (Pm), a lanthanide which is highly radioactive and inaccessible. Despite its significance, Pm has conspicuously been

NIST's Engagement with CCQM Studies from 1992 to 2023: History and Performance

May 21, 2024
Author(s)
David L. Duewer, Christina Cecelski, Megan Cleveland, Nancy Lin, Katrice Lippa, Jacqueline L. Mann, John L. Molloy, Michael Nelson, James E. Norris, Kenneth W. Pratt, Sumona Sarkar, Hratch G. Semerjian, Robert L. Watters
This report documents the engagement and measurement performance of the National Institute of Standards and Technology (NIST) in studies coordinated by the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (CCQM) from 1992
Displaying 1 - 25 of 2053