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Displaying 876 - 900 of 1612

Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance

April 26, 2012
Author(s)
Bryant C. Nelson, Bryce J. Marquis, Anna L. Seager, Ume K. Shah, Jane M. Mikhail, Shareen H. Doak, George E. Johnson, Paul L. Carmichael, Sharon J. Scott, Andrew D. Scott, Gareth J. Jenkins
Oxidative stress contributes to many disease aetiologies including ageing, neurodegeneration, and cancer, partly through DNA damage induction (genotoxicity). Understanding the interactions of free radicals with DNA is fundamental to discern the mutation

Three-dimensional Shape Metrology for Tissue Engineering

April 21, 2012
Author(s)
Joy P. Dunkers, Antonio M. Possolo, Thomas V. Lafarge, Beatriz Pateiro-Lopez, Jeffrey Coles, Carl G. Simon Jr.
The physical and chemical properties of a tissue scaffold influences cell response and therefore the success of the resulting tissue construct. Scaffold structure from nanometers to millimeters can direct cell behavior, from viability to proliferation to

Dielectrophoretic Cell Capture on Polyester Membranes

April 2, 2012
Author(s)
Conni Hanke, Petra S. Dittrich, Darwin Reyes-Hernandez
A new system for dielectrophoretic cell capture on porous polyester (PET) membranes is presented. Conventional photolithographic techniques were used to fabricate gold microelectrodes on a PET membrane. We characterized these electrodes to proof that there

Positively-charged Dimethacrylates to Reduce Bacterial Attachment

March 30, 2012
Author(s)
Nancy J. Lin, Joseph M. Antonucci, Diana N. Zeiger, Sheng Lin-Gibson, Kathy Tang
The widespread incidence of recurrent tooth decay (caries) highlights the need for improved dental restorative materials. Caries are most frequently caused by acid-producing bacterial biofilms. One approach for developing biomaterials with reduced

Tumor Necrosis Factor Interaction with Gold Nanoparticles

March 14, 2012
Author(s)
De-Hao D. Tsai, Sherrie R. Elzey, Frank W. DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael R. Zachariah, Athena M. Keene, Jeffrey D. Clogston, Vincent A. Hackley
We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spectroscopic

Freeform Fabricated Scaffolds with Roughened Struts that Enhance both Stem Cell Proliferation and Differentiation by Controlling Cell Shape

March 1, 2012
Author(s)
Girish Kumar, Carl G. Simon Jr., Michael S. Waters, Tanya M. Farooque, Marian F. Young
We demonstrate that imparting freeform fabricated (FFF) scaffolds with surface roughness on their struts enhances osteogenic differentiation of primary human bone marrow stromal cells (hBMSCs) by controlling cell shape. Previous work showed that hBMSCs

Predictive Gold Nanocluster Formation Controlled by Metal-Ligand Complexes

January 9, 2012
Author(s)
John M. Pettibone, Jeffrey W. Hudgens
The formation of ligand-protected transition metal nanoclusters in size-selective syntheses is driven by the inherent properties of the protecting ligands. We have previously reported the selective, monodisperse product formation of phosphine protected Au

Preparation and Value Assignment of Standard Reference Material 968e Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum

January 2, 2012
Author(s)
Jeanice M. Brown Thomas, David L. Duewer, Lane C. Sander, Katherine E. Sharpless, Lorna T. Sniegoski, Michael J. Welch, James H. Yen, Mugenya O. Isaac
Standard Reference Material 968e Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum provides certified values for total retinol, γ- and α-tocopherol; total lutein, total zeaxanthin, total β-cryptoxanthin, total β-carotene, and cholesterol in
Displaying 876 - 900 of 1612
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