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Displaying 851 - 875 of 1612

An instrumented bioreactor for mechanical stimulation and real-time, nondestructive evaluation of engineered cartilage tissue

June 1, 2012
Author(s)
Jenni R. Popp, Justine Roberts, Douglas V. Gallagher, Kristi S. Anseth, Stephanie Bryant, Timothy P. Quinn
Mechanical stimulation is essential for chondrocyte metabolism and cartilage matrix deposition. In vitro, mechanical stimulation is accomplished via culture in a bioreactor. Traditional methods for evaluating the developing tissue are destructive, time

On the need for an international effort to capture, share and use crystallisation screening data (failure and success)

June 1, 2012
Author(s)
David Travis Gallagher, Janet Newman, Evan E. Bolton, Jochen M?Dieckmann, Vincent J. Fazio, David Lovell, Joseph R. Luft, Thomas S. Peat, David Ratcliffe, Roger A. Sayle, Edward H. Snell, Kerry Taylor, Pascal Vallotton, Sameer Velankar, Frank V. Delft
Crystallisation of biological macromolecules is seen by most structural biologists as a necessary evil, a means to the end, which is knowledge about a macromolecular structure. Crystallization remains largely a trial-and-error process, with extensive

Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds

May 18, 2012
Author(s)
David W. Allen, Jeeseong Hwang, Maritoni A. Litorja, Joseph P. Rice
Biomedical optical imaging has the potential to achieve high spatial resolution and high functional sensitivity for non-invasive assessment of ischemic wounds. However, clinical acceptance of many optical imaging devices is hampered by poor reproducibility

Optimization of Imaging Polymer Based Scaffolds Using X-Ray Microcomputed Tomography

May 15, 2012
Author(s)
David E. Morris, Melissa L. Mather, Carl Simon Jr., John A. Crowe
The performance of polymer based scaffolds used in regenerative medicine is linked to their structural properties and as such strategies for structural characterization of scaffolds have been developed. X-ray microscopic computed tomography (X-ray micro CT

Designing Microarrays Phantoms for Hyperspectral Imaging Validation

May 9, 2012
Author(s)
Matthew L. Clarke, Ji Y. Lee, Daniel V. Samarov, David W. Allen, Maritoni A. Litorja, Ralph Nossal, Jeeseong Hwang
The simple design of custom-tailored microarrays for the characterization of hyperspectral imaging systems and analysis methods for biologically relevant samples. Individual and mixtures of dyes were printed on microscope slides and imaged by a

Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D

May 1, 2012
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Alison M. Kraigsley, Joachim Kohn, Durgadas Bolikal
Current methods for screening cell-material interactions typically utilize two-dimensional (2D) culture format where cells are cultured on flat surfaces. However, there is a need for combinatorial and high-throughput screening methods to systematically

Osteoblast Response to Serum Protein Adsorption in 3D Polymer Scaffolds

May 1, 2012
Author(s)
Carl G. Simon Jr., Girish Kumar, Kaushik Chatterjee, Stevephen Hung
Protein adsorption is known to direct biological response to biomaterials and is important in determining cellular response in tissue scaffolds. In this study we investigated the effect of adsorbed serum proteins on cell attachment and proliferation in

Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma

April 27, 2012
Author(s)
Zachary H. Levine, Adam L. Pintar, John G. Hagedorn, Charles D. Fenimore, Claus P. Heussel
The authors investigate the extent to which the RESPONSE Evaluation Criateria in Solid Tumors (RECIST) can predict tumor volumes and changes in volume using clinical data. The data presented are a reanalysis of data acquired in other studies, including the
Displaying 851 - 875 of 1612
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