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Displaying 326 - 350 of 484

DNA-Based Sensors

January 1, 2003
Author(s)
Michael J. Tarlov, A B. Steel
The development of DNA-based sensors for genetic assay and sequencing applications has exploded over the last decade. Nearly all of these devices rely on the hybridization of a complementary oligonucleotide with surface-confined, single-stranded DNA or RNA

Oxidative DNA Damage Biomarkers Used in Tissue Engineered Skin

January 1, 2003
Author(s)
H Rodriguez, Pawel Jaruga, M Birincioglu, Peter E. Barker, C D. O'Connell, M. Dizdaroglu
To assure that tissue engineered medical products are free of genetic changes that might occur from inflammation during the development phase of the product, our laboratory is responding to the need for test methods used to assess the safety and

A New NIST Mitochondrial DNA Interactive Website

August 1, 2002
Author(s)
Barbara C. Levin, L A. Tully, Diane K. Hancock, Frederick P. Schwarz, M S. Lee
Every human cell has from a few dozen to several thousand mitochondria each of which contain mitochondrial DNA (mtDNA). The sequence of the entire human mtDNA (16,569 base pairs) was determined and published by Anderson et al. in 1981. A mtDNA standard

Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA

March 19, 2002
Author(s)
T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W. Kow, Pawel Jaruga, Miral M. Dizdar, Somenath Mitra
8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including cancer

Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA

February 1, 2002
Author(s)
Pawel Jaruga, R Jabil, Amanda K. McCullough, H Rodriguez, M Miral Dizdar, R S. Lloyd
A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identity

Determination of Active Site Residues in Escherichia Coli Endonuclease VIII

January 25, 2002
Author(s)
S. M. Burgess, Pawel Jaruga, M L. Dodson, Miral M. Dizdar, R S. Lloyd
Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple
Displaying 326 - 350 of 484
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