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DNA-Based Sensors

Published

Author(s)

Michael J. Tarlov, A B. Steel

Abstract

The development of DNA-based sensors for genetic assay and sequencing applications has exploded over the last decade. Nearly all of these devices rely on the hybridization of a complementary oligonucleotide with surface-confined, single-stranded DNA or RNA, so-called probes, for measuring nucleic acid analytes. In this review, the basic anatomy, fabrication, operating principles, transduction strategies, and applications of DNA-based sensors are described. Recent developments in DNA-based sensors using electrochemical, optical, mass, scanning probe, or microcantilever transduction are reviewed. In addition, the development of DNA-based sensors for measuring other analytes such as proteins, metal ions, and small organic molecules is also examined.
Citation
Biomolecular Films: Design, Function, and Applications
Volume
12
Publisher Info
CRC, Boca Raton, FL

Keywords

catalytic DNA, catalytic RNA, diagnostics, DNA, electrochemistry, genetic assays, nucleic acids, sensing, SPR

Citation

Tarlov, M. and Steel, A. (2003), DNA-Based Sensors, CRC, Boca Raton, FL (Accessed July 14, 2024)

Issues

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Created January 1, 2003, Updated February 19, 2017