Tarlov, M.
and Steel, A.
(2003),
DNA-Based Sensors, CRC, Boca Raton, FL
(Accessed October 14, 2024)
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DNA-Based Sensors
Published
Author(s)
, A B. Steel
Abstract
The development of DNA-based sensors for genetic assay and sequencing applications has exploded over the last decade. Nearly all of these devices rely on the hybridization of a complementary oligonucleotide with surface-confined, single-stranded DNA or RNA, so-called probes, for measuring nucleic acid analytes. In this review, the basic anatomy, fabrication, operating principles, transduction strategies, and applications of DNA-based sensors are described. Recent developments in DNA-based sensors using electrochemical, optical, mass, scanning probe, or microcantilever transduction are reviewed. In addition, the development of DNA-based sensors for measuring other analytes such as proteins, metal ions, and small organic molecules is also examined.Citation
Biomolecular Films: Design, Function, and Applications
Volume
12
Publisher Info
CRC, Boca Raton, FL
Pub Type
Books
Keywords
catalytic DNA, catalytic RNA, diagnostics, DNA, electrochemistry, genetic assays, nucleic acids, sensing, SPR
Citation
Issues
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Created January 1, 2003, Updated February 19, 2017