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Neutron research

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Displaying 76 - 100 of 925

Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

January 16, 2024
Author(s)
Jacob Thelen, Wellington Leite, Volker Urban, Hugh O'Neill, Alexander Grieshaev, Joseph E. Curtis, Susan N. Krueger, Maria M. Castellanos
The mRNA technology has emerged as a rapid modality to develop vaccines during pandemic situations with the potential to protect against endemic diseases. The success of mRNA in producing an antigen is dependent on the ability to deliver mRNA to the cells

Antivesiculation and Complete Unbinding of Tail-Tethered Lipids

January 8, 2024
Author(s)
Kuo-Chih Shih, Geoffray Leriche, Chung-Hao Liu, Jibao He, Vijay John, John Barker, Michihiro Nagao, Lin Yang, Jerry Yang, Mu-Ping Nieh
We report the effect of tail-tethering on vesiculation and complete unbinding of bilayered membranes. Amphiphilic molecules of a bolalipid, resembling the tail-tethered molecular structure of archaeal lipids, with two identical zwitterionic

Bulk Elastic Constants And Their Role In Diffractive Stress Analysis

January 1, 2024
Author(s)
Thomas Gnaupel-Herold
The accuracy of stress determination depends to a large extent on the accuracy to which the diffraction elastic constants (DEC) can be obtained. DEC calculations require primarily single crystal elastic constants as input; however, large disparities

Elastic Behavior of Orientation-Correlated Grains in Multiphase Aggregates

December 1, 2023
Author(s)
Thomas Gnaupel-Herold
Diffraction elastic constants (DECs) describe the elastic response of a subset of orientation-correlated grains which share a common lattice vector. DECs reflect the elastic behaviour of the single-crystal constituents through their dependence on grain

Hydrogen-Deuterium Exchange Dynamics of NISTmAb Measured by Small Angle Neutron Scattering

November 14, 2023
Author(s)
Roisin Donnelly, Sai Pingali, Luke Heroux, Robert Brinson, Norman J. Wagner, Yun Liu
Understanding protein dynamics and conformational stability holds great significance in biopharmaceutical research. Hydrogen−deuterium exchange (HDX) is a quantitative methodology used to examine these fundamental properties of proteins. HDX involves

Observation of Interpenetrated Topology Isomerism for Covalent Organic Frameworks with Atom-Resolution Single Crystal Structures

November 9, 2023
Author(s)
Baoqiu Yu, Wenliang Li, Xiao Wang, Jing-Hong Li, Rui-Biao Lin, Hailong Wang, Xu Ding, Yucheng Jin, Xiya Yang, Hui Wu, Wei Zhou, Jingping Zhang, Jianzhuang Jiang
Rational control and understanding of isomerism are of significance but still remain a great challenge in reticular frameworks, in particular, for covalent organic frameworks (COFs) due to the complicated synthesis and energy factors. Herein, reaction of 3

Simultaneous characterization of operando multi-material distribution via high-contrast correlative tomographic microscopy

November 8, 2023
Author(s)
Pranay Shrestha, Jacob LaManna, Kieran Fahy, Pascal Kim, ChungHyuk Lee, Jason Lee, Elias Baltic, David Jacobson, Daniel Hussey, Aimy Bazylak
High-contrast tomographic microscopy of evolving multi-material systems, such as electrochemical devices, offers a unique and often exclusive perspective into inner workings of these complex systems. Here, we characterize the operando spatiotemporal

Synthesis, Structure and Canted Antiferromagnetism of Layered Cobalt Hydroxide Sorbate

November 1, 2023
Author(s)
Jonathan B. Lefton, Wenhao Liu, Claire Lamberti, Bing Lv, Craig Brown, Ryan Klein, Tom Runcevski
Layered hybrid organic–inorganic compounds of the transition metal hydroxides, in which part of the hydroxide ions are exchanged for organic ligands that act as spacers of the 2-dimensional inorganic layers, elicit new or enhanced properties. The

Adaptive Pore Opening to Form Tailored Adsorption Sites in a Cooperatively Flexible Framework Enables Record Inverse Propane/Propylene Separation

October 11, 2023
Author(s)
Ryan Klein, Lukas Bingel, Arijit Halder, Marcus Carter, Benjamin Trump, Eric Bloch, Wei Zhou, Krista Walton, Craig Brown, C. McGuirk
A proposed low-energy alternative to the separation of alkanes from alkenes by energy-intensive cryogenic distillation is separation by porous adsorbents. Unfortunately, most adsorbents preferentially take up the desired, high-value major component alkene

A thermodynamic analysis of CLC transporter dimerization in lipid bilayers

October 10, 2023
Author(s)
Rahul Chadda, Taeho Lee, Robyn Mahoney-Kruszka, Elizabeth Kelley, Nathan Bernhardt, Priyanka Sandal, Janice Robertson
The CLC-ec1 chloride/proton antiporter is a membrane-embedded homodimer with subunits that can dissociate and associate, but the thermodynamic driving forces favor the assembled dimer at biological densities. Yet, the physical reasons for this stability

Role of Domain-Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt

September 26, 2023
Author(s)
Amy Xu, Marco Blanco, Maria Castellanos, Curtis Meuse, Kevin Mattison, Ioannis Karageorgos, Harold Hatch, Vincent Shen, Joseph E. Curtis
Monoclonal antibodies (mAbs) make up a major class of biotherapeutics with a wide range of clinical applications. Their physical stability can be affected by various environmental factors. For instance, an acidic pH can be encountered during different

Linkage conversions in single-crystalline covalent organic frameworks

September 18, 2023
Author(s)
Baoqiu Yu, Rui-Biao Lin, Gang Xu, Zhi-Hua Fu, Hui Wu, Wei Zhou, Shanfu Lu, Qian-Wen Li, Yucheng Jin, Jing-Hong Li, Zhenguo Zhang, Hailong Wang, Zier Yan, Xiaolin Liu, Kang Wang, Banglin Chen, Jianzhuang Jiang
Single-crystal X-ray diffraction is a powerful characterization technique that enables the determination of atomic arrangements in crystalline materials. Growing or retaining large single crystals amenable to it has, however, remained challenging with

Pore Modulation of Hydrogen-Bonded Organic Frameworks for Efficient Separation of Propylene

September 11, 2023
Author(s)
Youlie Cai, Junkuo Gao, Jing-Hong Li, Puxu Liu, Yanchun Zheng, Wei Zhou, Hui Wu, Libo Li, Rui-Biao Lin, Banglin Chen
Developing hydrogen-bonded organic frameworks (HOFs) that combine functional sites, size control, and storage capability for targeting gas molecule capture is a novel and challenging venture. However, there is a lack of effective strategies to tune the

Air-Stable Cu(I) Metal-Organic Framework for Hydrogen Storage

September 1, 2023
Author(s)
Debabrata Sengupta, Patrick Melix, Saptasree Bose, Joshua Duncan, Xingjie Wang, Mohammad Mian, Kent Kirlikovali, Faramarz Joodaki, Timur Islamoglu, Taner N. Yildirim, Randall Snurr, Omar Farha
Metal−organic frameworks (MOFs) that contain open metal sites have the potential for storing hydrogen (H2) at ambient temperatures. In particular, Cu(I)-based MOFs demonstrate very high isosteric heats of adsorption for hydrogen relative to other reported

Layered Porous Molecular Crystals via Interdigitation-Directed Assembly

August 16, 2023
Author(s)
Nie Fang, Siquan Zhang, Zhenchuang Xu, Si Chen, Xu Zhang, Hui Wu, Wei Zhou, Yanchuan Zhao
Building robust porous molecular architectures with van der Waals interactions holds promise for advancements in catalysis, chemosensing, and separation techniques. In a macroscopic context, grand buildings, toy houses, and jigsaw puzzles can be

Neutron Spin Echo Spectroscopy with a Moving Sample

August 11, 2023
Author(s)
Manuchar Gvaramia, Philipp Gutfreund, Peter Falus, Antonio Faraone, Michihiro Nagao, Max Wolff
Neutron spin echo spectroscopy is a high resolution inelastic neutron scattering method probing nanosecond dynamics. It is well suited to study the atomistic motion in polymer systems and contributes to our understanding of viscoelasticity. However, for

Assessment of Dose Reduction Strategies in Wavelength-Selective Neutron Tomography

July 31, 2023
Author(s)
Daniel Hussey, Peter Bajcsy, Paul A. Kienzle, Jacob LaManna, David Jacobson, Victoria DiStefano, Daniel Pelt, James Sethian
The goal of this study is to determine variable relationships and a computational workflow that yield the highest quality of three-dimensional reconstructions in neutron imaging applications with reduced number of projections angles. Neutrons interact with
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