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Forensic Science

Forensic genetics

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Displaying 201 - 225 of 252

Gene Expression Analysis on Medium-Density Oligonucleotide Arrays

January 1, 2001
Author(s)
R. Sinibaldi, C D. O'Connell, H Rodriguez, C. Seidel
As the human genome project continues toward its goal of sequencing the entire human genome by the end of 2003, this is providing unique opportunities for studying genetic variation in humans and its relationship with disease risk and aging. Consequently

Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines

December 1, 2000
Author(s)
C. Dherin, M. Dizdaroglu, H. Doerflinger, S. Boiteux, J. P. Radicella
In Drosophila, the S3 ribosomal protein has been shown to act as a DNA glycosylase/AP lyase capable of releasing 8-hydroxyguanine (8-OH-Gua) in damaged DNA. Here we describe a second Drosophila protein (dOggl) with 8-OH-Gua and abasic (AP) site DNA repair

The Protein Data Bank and the Challenge of Structural Genomics

November 1, 2000
Author(s)
H M. Berman, Talapady N. Bhat, P E. Bourne, Z. Feng, G L. Gilliland, H Weissig, J Westbrook
The determination of structures on a genomic scale in a high-throughput mode will have an impact on every aspect of the Protein Data Bank (PDB) - the single archive for all biomacromolecular structural data. Although estimates vary, the PDB could triple in

Stressing-Out DNA? The Contribution of Serine-Phosphodiester Interactions in Catalysis by Uracil DNA Glycosylase

October 17, 2000
Author(s)
R M. Werner, Y. L. Jiang, R. G. Gordley, J. Jagadeesh, Jane E. Ladner, G Xiao, M Tordova, G L. Gilliland, J T. Stivers
The DNA repair enzyme uracil DNA glycosylase (UDG) pinches the phosphodiester backbone of damaged DNA using the hydroxyl side chains of a conserved trio of serine residues, resulting in flipping of the deoxyuridine from the DNA helix into the enzyme active

Driven DNA Transport Into an Asymmetric Nanometer-Scale Pore

October 2, 2000
Author(s)
S. E. Henrickson, Martin Misakian, B Robertson, John J. Kasianowicz
To understand the mechanism by which individual DNA molecules partition into a nanometer-scale pore, we studied the concentration and voltage dependence of polynucleotide-induced current blockades of single a-hemolysin ionic channels. At fixed single

Human Mitochondrial Genetics

January 1, 2000
Author(s)
L A. Tully, Barbara C. Levin
The field of human mitochondrial genetics has advanced way beyond where the Human Genome Project hopes to be by the year 2003, the projected year for completing the sequence of the entire human nuclear DNA genome. Not only has the mitochondrial DNA (mtDNA)
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