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The abilities and limitations of mass spectrometry method in structure determination of bioorganic molecules containing three- and four-membered rings is discussed. Implementation of chemicals is considered.
Anzor Mikaia, Alla V. Antonova, Vladimir G. Zaikin, Nikolay A. Prostakov, Nikolay Vulfson, Igor Torgov
A GC-MS method is developed for structure determination of steroid alcohols. The method includes dehydrogenation of steroid alcohols on a copper powder at 325 oC.
Anzor Mikaia, Vladimir G. Zaikin, Alla V. Antonova, Nikolay A. Prostakov
On line H/D exchange is applied to carbonyl compounds prior mass spectrometry analysis on a GC column containing 10% KOD. This exchange reaction can be used for other compounds undergoing keto-enol tautomerism.
Anzor Mikaia, Elena Trusova, Vladimir G. Zaikin, Naum Volinsky, Elena Karaulova, Gregory Galpern
A GC-MS method is developed for structure determination of thiacyclanes. It is based on online gas- phase hydro- and deutero-desulfurization on Raney nickel after GC separation and before MS analysis.
The use of deuterium as a carrier and reagent gas for structural determination of alkenes, cyclopropane compounds and cyclic sulphides by reaction GC-MS is described. Catalytic transformation of analytes is accomplished in an on-line gas-phase microreactor
Anzor Mikaia, Alla V. Antonova, Vladimir G. Zaikin, Nikolay A. Prostakov, Vladimir Y. Rumyantsev, Evgenyi Slivinsky, Sergai Loktev
A GC-MS method is developed for the study of C 4 -C10 aliphatic diols in complex mixtures. The method includes a GC column trimethylsilylation with N,0-bis(trimethylsilyl)trifluoroacetamide.
Anzor Mikaia, Vladimir G. Zaikin, Vladimir Trusov, Andrei Nekhaev, Vladimir Tyurin
Under electron ionization conditions decarbonylation precedes the fragmentation of ligands in iron hexacarbonyl complexes and involves a rupture of metal-ligand bonds.
Decomposition of cyclopropane and cyclobutane containing compounds with Carbon, Silicon and Germanium atoms under mass spectrometry conditions is discussed.